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1. 骨壊死症（無血管性骨壊死症）osteonecrosis avascular necrosis of bone [show details]
…disorder develops are not fully understood. Compromise of the bone vasculature, leading to the death of bone and marrow cells (bone marrow infarction), and ultimate mechanical failure appear to be common …
2. 再生不良性貧血：発症機序、臨床症状、診断aplastic anemia pathogenesis clinical manifestations and diagnosis [show details]
… induces the Fas receptor, and both are implicated in increased apoptotic death of HSCs in AA . IFN gamma is detected in the bone marrow of patients with acquired AA, and disappears in response to immunosuppression …
3. 多発性骨髄腫：病理生物学的特徴multiple myeloma pathobiology [show details]
… cell proliferation due to cell cycle dysregulation; Evasion of programmed cell death (apoptosis) Changes in the bone marrow microenvironment; The sequence of events, however, is not clear. The major changes …
4. 骨髄異形成症候群の臨床症状および診断clinical manifestations and diagnosis of the myelodysplastic syndromes [show details]
… of peripheral pancytopenia despite the presence of a hypercellular bone marrow reflects premature cell loss via intramedullary cell death (apoptosis) . Although hypocellularity is uncommon, it is found with …
5. 好中球機能異常症の検査での評価laboratory evaluation of neutrophil disorders [show details]
… physical examination, complete blood count, peripheral blood smear, bone marrow, and/or neutrophil function assay. We are saddened by the death of Laurence A Boxer, MD, who passed away in January 2017. UpToDate …

English Journal

Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity.

Krześniak M, Zajkowicz A, Gdowicz-Kłosok A, Głowala-Kosińska M, Łasut-Szyszka B, Rusin M.
Cellular signalling. 2020 May;69()109552.
Actinomycin D and nutlin-3a (A + N) activate p53, partly through induction of phosphorylation on Ser392. The death of A549 cells induced by A + N morphologically resembles inflammation-inducing pyroptosis - cell destruction triggered by activated caspase-1. The treatment with A + N (or c
PMID 32032660

Cytomegalovirus Viremia and Death After Hematopoietic Cell Transplantation: More Complex Than "To Have and Have Not"?

Perales MA, Papanicolaou GA.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020 Apr;70(8)1534-1535.
PMID 31179483

Evidence of Clinically Meaningful Drug-Drug Interaction With Concomitant Use of Colchicine and Clarithromycin.

Villa Zapata L, Hansten PD, Horn JR, Boyce RD, Gephart S, Subbian V, Romero A, Malone DC.
Drug safety. 2020 Apr;().
Colchicine is currently approved for the treatment of gout and familial Mediterranean fever, among other conditions. Clarithromycin, a strong inhibitor of CYP3A4 and P-glycoprotein, dramatically increases colchicine's half-life, augmenting the risk of a life-threatening adverse reaction when used in
PMID 32274687

Japanese Journal

喀痰のGiemsa染色で診断された白血病肺浸潤

尾﨑正英,新家裕朗,後藤辰徳,森下喬允,小澤幸泰,伊藤雅文,宮村耕一,李尹河,長村陽子,一木朝絵,岡部基人,川口裕佳,大引真理恵,伊藤藍,後藤実世
臨床血液 61(3), 257-261, 2020
<p>急性骨髄性白血病の非寛解期にHLA適合非血縁ドナーより同種骨髄移植を受けた54歳男性。移植後day14の骨髄検査では寛解に至っていたものの，day28の骨髄検査で再発を確認した。湿性咳嗽を認めるようになり，day27のCT検査で肺炎像を認めた。その後，末梢血中の芽球が増えると同時に肺炎像は悪化した。白血病肺浸潤を疑い，喀痰のGiemsa染色を行ったところ，喀痰中に芽球を認めた。喀 …
NAID 130007821392

悪性腫瘍（特に小児悪性腫瘍）に対する確定診断と予後因子検索とその新規治療薬の研究開発

鈴木孝
薬学雑誌 140(2), 229-271, 2020
… <p>Outcomes of treatment for malignant pediatric tumors including leukemia are improving by conventional multimodal treatment with strong chemotherapy, surgical resection, radiotherapy, and bone marrow transplantation. … Apoptotic cell death is a key mechanism for normal cellular homeostasis. … Genetic aberrations disrupting programmed cell death often underpin tumorigenesis and drug resistance. …
NAID 130007793387

Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression via CCR5

Nishikawa Gen,Kawada Kenji,Nakagawa Jun,Toda Kosuke,Ogawa Ryotaro,Inamoto Susumu,Mizuno Rei,Itatani Yoshiro,Sakai Yoshiharu
Cell Death
Mesenchymal stem cells (MSCs) are recruited from BM to the stroma of developing tumors, where they serve as critical components of the tumor microenvironment by secreting growth factors, cytokines, an …
NAID 120006596558