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1. 抗エリスロポエチン抗体による赤芽球癆pure red cell aplasia due to anti erythropoietin antibodies [show details]
… percent red blood cell precursors, and there may be evidence of a block in the maturation of erythroid precursors. Platelet and white cell precursors are entirely normal. Anti-EPO antibodies are detected by …
2. 腫瘍随伴性小脳変性症paraneoplastic cerebellar degeneration [show details]
… target antigens of anti-Yo antibodies are the cerebellar degeneration related (CDR) proteins that are expressed by Purkinje cells and ovarian and breast cancers . A cytotoxic T cell response against CDR2 …
3. 赤血球抗原および抗体red blood cell antigens and antibodies [show details]
… Donath-Landsteiner antibody . This cold reactive IgG antibody binds to RBCs at reduced temperatures and causes complement mediated hemolysis as the serum/cell mixture is warmed to body temperature. Anti-I – Most …
4. 関節リウマチのためのT細胞標的療法t cell targeted therapies for rheumatoid arthritis [show details]
… monoclonal antibodies (mAbs) were among the first attempts at developing biologic agents for the rheumatic diseases. T-cell receptors – T-cell receptors (TcRs) expressed on pathogenic synovial T cells offer… Clinical trials using two different anti-CD40 ligand monoclonal antibodies (mAbs) have been attempted in systemic lupus erythematosus,…
5. 悪性腫瘍関連胃不全麻痺：病態生理およびマネージメントmalignancy associated gastroparesis pathophysiology and management [show details]
…gastrointestinal dysmotility include antineuronal antibodies type 2 (ANNA-2 or anti-Ri), amphiphysin antibody, type 1 Purkinje cell cytoplasmic antibody (PCA-1, also called anti-Yo), PCA-2, PCA-Tr, collapsing response …

English Journal

Paraneoplastic cerebellar syndromes associated with antibodies against Purkinje cells.

Schwenkenbecher P, Chacko L, Pul R, Sühs KW, Wegner F, Wurster U, Stangel M, Skripuletz T.
The International journal of neuroscience. 2018 Aug;128(8)721-728.
The paraneoplastic cerebellar syndrome presents as severe neuroimmunological disease associated with malignancies. Antibodies against antigens expressed by tumor cells cross-react with proteins of cerebellar Purkinje cells leading to neuroinflammation and neuronal loss. These antineuronal antibodies
PMID 29199513

Paraneoplastic cerebellar degeneration in a patient with a primary fallopian tube adenocarcinoma. A case report and brief review.

Campero M, Selman AE.
Gynecologic oncology reports. 2017 May;20()90-92.
We describe a 65-year-old woman with subacute cerebellar syndrome expressed as severe ataxia, and the presence of anti Purkinje cell antibodies (Anti-Yo). A small adnexal mass was only evident on PET CT with the pathological feature of fallopian tube adenocarcinoma. Anti-Yo antibodies have been stro
PMID 28386581

Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers.

Greenlee JE, Clawson SA, Hill KE, Wood B, Clardy SL, Tsunoda I, Carlson NG.
PloS one. 2015 ;10(4)e0123446.
Anti-Yo antibodies are immunoglobulin G (IgG) autoantibodies reactive with a 62 kDa Purkinje cell cytoplasmic protein. These antibodies are closely associated with paraneoplastic cerebellar degeneration in the setting of gynecological and breast malignancies. We have previously demonstrated that inc
PMID 25885452