WordNet
- to remain unmolested, undisturbed, or uninterrupted -- used only in infinitive form; "let her be"
- work in a specific place, with a specific subject, or in a specific function; "He is a herpetologist"; "She is our resident philosopher" (同)follow
- have life, be alive; "Our great leader is no more"; "My grandfather lived until the end of war" (同)live
- be identical to; be someone or something; "The president of the company is John Smith"; "This is my house"
- happen, occur, take place; "I lost my wallet; this was during the visit to my parents house"; "There were two hundred people at his funeral"; "There was a lot of noise in the kitchen"
- have the quality of being; (copula, used with an adjective or a predicate noun); "John is rich"; "This is not a good answer"
- occupy a certain position or area; be somewhere; "Where is my umbrella?" "The toolshed is in the back"; "What is behind this behavior?"
- spend or use time; "I may be an hour"
- stake on the outcome of an issue; "I bet $100 on that new horse"; "She played all her money on the dark horse" (同)wager, play
- the act of gambling; "he did it on a bet" (同)wager
- maintain with or as if with a bet; "I bet she will be there!" (同)wager
- second in order of importance; "the candidate, considered a beta male, was perceived to be unable to lead his party to victory"
- the 2nd letter of the Greek alphabet
- preliminary or testing stage of a software or hardware product; "a beta version"; "beta software"
- a substance from which another substance is formed (especially by a metabolic reaction)
- a person who goes before or announces the coming of another (同)forerunner
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
PrepTutorEJDIC
- 《連結語として補語を伴なって…『である』,…だ,…です / 《位置・場所を表す語句を伴って》(…に)『ある』,いる(occupy a place or situation) / 〈物事が〉『存在する』,ある(exist);〈生物が〉生存する,生きている(live) / 行われる,起こる,発生する(take place, occur) / 存続する,そのままでいる(remain as before) / 《『be to』 do》 / …する予定である,…することになっている / …すべきだ / 《受動態の不定詞を伴って》…できる / 《命令》…するのだ / 《条件節に》…する意図がある / 《『if…were to』 do》…するとしたなら / 《『be』 do『ing』》《進行形》 / 《進行中の動作》…している,しつつある / 《近い未来》…しようとしている,するつもり / 《動作の反復》(いつも)…している / 《『be』+『他動詞の過去分詞』》《受動態》…される,されている / 《『be』+『自動詞の過去分詞』》《完了形》…した[状態にある]
- 『かけ』・(…との)かけ《+『with』+『名』》 / かけた物(金) / かけの対象 / 〈金・物〉'を'『かける』 / (かけ事・ゲームなどで)〈人〉‘と'『かけをする』《+『名』〈人〉+『on』+『名』》 / (…に)『かける』《+『on』(『against』)+『名』(one's do『ing』)》
- ベータ(ギリシア語アルファベットの第2文字;B,β;英語のB,b に遭当)
- (…の)前朕,前触れ《+『of』+『名』》
- 蛋白(たんばく)質
UpToDate Contents
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- 1. アミロイド疾患の遺伝的要因 genetic factors in the amyloid diseases
- 2. アルツハイマー病の遺伝学 genetics of alzheimer disease
- 3. 脳アミロイドアンギオパチー cerebral amyloid angiopathy
- 4. Overview of amyloidosis
- 5. 炎症性ミオパチーの病因 pathogenesis of inflammatory myopathies
English Journal
- APP transgenic mice and their application to drug discovery.
- Howlett DR.SourceKing's College Wolfson Centre for Age Related Diseases, King's College London, St Thomas' Street, London, UK. david.howlett@kcl.ac.uk.
- Histology and histopathology.Histol Histopathol.2011 Dec;26(12):1611-32.
- The development of transgenic mice expressing mutated forms of the human amyloid precursor protein (APP) and presenilin-1 (PS1), proteins associated with familial forms of Alzheimer's disease (AD), has provided a backbone for translational studies of potential novel drug therapies. Such mice model s
- PMID 21972099
- Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis.
- Bailey JA, Maloney B, Ge YW, Lahiri DK.SourceLaboratory of Molecular Neurogenetics, Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
- Gene.Gene.2011 Nov 15;488(1-2):13-22. Epub 2011 Jun 25.
- Amyloid-β peptide (Aβ) plaque in the brain is the primary (post mortem) diagnostic criterion of Alzheimer's disease (AD). The physiological role(s) of Aβ are poorly understood. We have previously determined an Aβ interacting domain (AβID) in the promoters of AD-associated genes (Maloney and Lah
- PMID 21708232
Japanese Journal
- Cytoplasmic Fragment of Alcadein alpha Generated by Regulated Intramembrane Proteolysis Enhances Amyloid beta-Protein Precursor (APP) Transport into the Late Secretory Pathway and Facilitates APP Cleavage
- Journal of biological chemistry 290(2), 987-995, 2015-01-09
- NAID 120005567733
- Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport
- Molecular biology of the cell 25(22), 3569-3580, 2014-11-05
- NAID 120005522339
- Identification and quantification of amyloid beta-related peptides in human plasma using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
- Proceedings of the Japan Academy. Ser. B, Physical and Biological Sciences 90(3), 104-117, 2014-03
- NAID 40020025425
Related Links
- Like Dr. Jekyll and Mr. Hyde, some seemingly innocent proteins have evil alter egos. The amyloid-beta precursor protein is an important example. It is a large membrane protein that normally plays an essential role in neural growth ...
- Amyloid Precursor Protein (APP) is a type-I transmembrane protein enriched in neuronal tissues that undergoes sequential proteolytic processing through two distinct pathways. One pathway generate non-pathogenic molecules while ...
- This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase ...
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★リンクテーブル★
| リンク元 | 「アミロイドβ前駆体タンパク質」「amyloid beta-protein precursor」 |
| 関連記事 | 「precursor」「amyloid beta」「precursor protein」「amyloid」「beta」 |
「アミロイドβ前駆体タンパク質」
「amyloid beta-protein precursor」
「precursor」
- n.
「amyloid beta」
「precursor protein」
「amyloid」