アミドヒドラーゼ
- 関
- amidase
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/27 12:08:04」(JST)
[Wiki en表示]
Amidohydrolases (or amidases) are a type of hydrolase that acts upon amide bonds.
They are categorized under EC number EC 3.5.1 and 3.5.2.
Examples include:
- Beta-lactamase
- Histone deacetylase
- Urease
The amidohydrolase superfamily is a large protein family of more than 20,000 members with diverse chemistry and physiologic roles. Due to its complexity and size, the amidohyrolase superfamily is being used by the Enzyme Function Initiative (EFI) for developing a large-scale strategy for functional assignment of unknown proteins.
See also
External links
- Amidohydrolases at the US National Library of Medicine Medical Subject Headings (MeSH)
- CRISP Thesaurus 00000306
- Amidohydrolase Overview from the EFI
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Hydrolases: carbon-nitrogen non-peptide (EC 3.5)
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3.5.1: Linear amides /
Amidohydrolases |
- Asparaginase
- Glutaminase
- Urease
- Biotinidase
- Aspartoacylase
- Ceramidase
- Aspartylglucosaminidase
- Fatty acid amide hydrolase
- Histone deacetylase
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3.5.2: Cyclic amides/
Amidohydrolases |
- Barbiturase
- Beta-lactamase
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3.5.3: Linear amidines/
Ureohydrolases |
- Arginase
- Agmatinase
- Protein-arginine deiminase
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3.5.4: Cyclic amidines/
Aminohydrolases |
- Guanine deaminase
- Adenosine deaminase
- AMP deaminase
- Inosine monophosphate synthase
- DCMP deaminase
- GTP cyclohydrolase I
- Cytidine deaminase
- AICDA
- Activation-induced cytidine deaminase
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3.5.5: Nitriles/
Aminohydrolases |
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| 3.5.99: Other |
- Riboflavinase
- Thiaminase II
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Enzymes
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| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
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| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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| Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
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English Journal
- N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors.
- Sunduru N1, Svensson M2, Cipriano M2, Marwaha S1, Andersson CD1, Svensson R3, Fowler CJ2, Elofsson M1.
- Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2017 Dec;32(1):513-521. doi: 10.1080/14756366.2016.1265520.
- PMID 28114819
- Synthesis of chiral pyrazolo[4,3-e][1,2,4]triazine sulfonamides with tyrosinase and urease inhibitory activity.
- Mojzych M1,2, Tarasiuk P1, Kotwica-Mojzych K3, Rafiq M4,5, Seo SY4, Nicewicz M2, Fornal E6.
- Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2017 Dec;32(1):99-105. doi: 10.1080/14756366.2016.1238362. Epub 2016 Oct 25.
- PMID 27778522
- Isolation, characterization, and in silico, in vitro and in vivo antiulcer studies of isoimperatorin crystallized from Ostericum koreanum.
- Raza H1, Abbas Q1, Hassan M1, Eo SH1, Ashraf Z1, Kim D2, Phull AR1, Kim SJ1, Kang SK2, Seo SY1.
- Pharmaceutical biology.Pharm Biol.2017 Dec;55(1):218-226.
- PMID 27927061
Japanese Journal
- 2P-069 好熱性Brevibacillus sp.の生産するオリゴ乳酸分解酵素の性質解明(酵素学,酵素工学,一般講演)
- In vivo immobilization of D-hydantoinase in Escherichia coli(BIOCHEMICAL ENGINEERING)
- Characterization and application of a L-specific amino acid oxidase from Rhodococcus sp. AIU LAB-3(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
Related Links
- amidohydrolase am·i·do·hy·dro·lase (ām'ĭ-dō-hī'drə-lās', -lāz', ə-mē'-) n. An enzyme that catalyzes the hydrolysis of the C-N bond in an amide. Also called deamidase, deamidizing enzyme.
- Amidohydrolase definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now! ... amidohydrolase am·i·do·hy·dro·lase (ām'ĭ-dō-hī'drə-lās', -lāz', ə-mē'-) n. An enzyme that catalyzes ...
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- amidohydrolase
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