WordNet

first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
make fit for, or change to suit a new purpose; "Adapt our native cuisine to the available food resources of the new country" (同)accommodate
any high mountain

PrepTutorEJDIC

アルファ(ギリシア語アルファベットの第1字A,α;英語のA,aに相当) / アルファ星(星座の主星)
(…に)…'を'『適応させる』,適合させる《+『名』+『to』+『名』(do『ing』)》 / (…向きに)〈小説・戯曲など〉'を'『脚色する』,翻案する,書きかえる《+『名』+『for』+『名』》 / (環境などに)適応する,順応する《+『to』+『名』》
高山,高峰

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Requirement of Gαi1/3-Gab1 signaling complex for keratinocyte growth factor-induced PI3K-AKT-mTORC1 activation.

Zhang YM1, Zhang ZQ2, Liu YY2, Zhou X1, Shi XH1, Jiang Q3, Fan DL1, Cao C2.
The Journal of investigative dermatology.J Invest Dermatol.2015 Jan;135(1):181-91. doi: 10.1038/jid.2014.326. Epub 2014 Jul 31.
Keratinocyte growth factor (KGF), also termed as fibroblast growth factor-7, promotes proliferation, migration, and adhesion of skin keratinocytes via binding to keratinocyte growth factor receptor (KGFR) and subsequent activation of downstream signaling including the PI3K-AKT-mTORC1 pathway. Here,
PMID 25078664

Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers.

Lefort S1, Joffre C, Kieffer Y, Givel AM, Bourachot B, Zago G, Bieche I, Dubois T, Meseure D, Vincent-Salomon A, Camonis J, Mechta-Grigoriou F.
Autophagy.Autophagy.2014 Dec 2;10(12):2122-42. doi: 10.4161/15548627.2014.981788.
The triple-negative breast cancer (TN BC) subtype is the most aggressive form of invasive BC. Despite intensive efforts to improve BC treatments, patients with TN BC continue to exhibit poor survival, with half developing resistance to chemotherapy. Here we identify autophagy as a key mechanism in t
PMID 25427136

Feng X1, Chen Q2, Gutkind JS3.
Oncotarget.Oncotarget.2014 Nov 30;5(22):10997-9.
The core components of the Hippo pathway are conserved from flies to mammals. In humans, these include a kinase cascade initiated by the Hippo kinase MST1/2 associated with the adaptor protein WW45/SAV1, and LATS1/2 in complex with MOB1, which in turn, phosphorylates and inhibits the mammalian trans
PMID 25526026

The appendage domain of alpha-adaptin is a high affinity binding site for dynamin

The sequence of a 22.4kb DNA fragment from the left arm of yeast chromosome II reveals homologues to bacterial proline synthetase and mouse alpha-adaptin, as well as a new permease and a DNA-binding protein