WordNet

the means of connection between things linked in series (同)nexus
a unit of length equal to 1/100 of a chain
an interconnecting circuit between two or more locations for the purpose of transmitting and receiving data (同)data link
a fastener that serves to join or connect; "the walls are held together with metal links placed in the wet mortar during construction" (同)linkup, tie, tie-in
(computing) an instruction that connects one part of a program or an element on a list to another program or list
the 24th letter of the Roman alphabet (同)x, ex
immunological disorder in which some part of the bodys immune system is inadequate and resistance to infectious diseases is reduced

PrepTutorEJDIC

(鎖の)『輪』,環 / 鎖のようにつながったソーセージの一節 / (…と)つなぐ物(人),(…との)きずな,つながり《+『with』(『to』)+『名』》 / 《複数形で》=cuff links / …‘を'『つなぎ合わせる』,連結する;(…と)…‘を'つなぐ《+『名』+『with』(『to』)+『名』》 / (…と)結合する,つながる《+[『up』(『together』)]『with』+『名』》
たいまつ
Christ / Christian
x-axis

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Invasive pneumococcal disease in children can reveal a primary immunodeficiency.

Gaschignard J1, Levy C2, Chrabieh M3, Boisson B4, Bost-Bru C5, Dauger S6, Dubos F7, Durand P8, Gaudelus J9, Gendrel D10, Gras Le Guen C11, Grimprel E12, Guyon G13, Jeudy C14, Jeziorski E13, Leclerc F15, Léger PL16, Lesage F17, Lorrot M18, Pellier I14, Pinquier D19, de Pontual L9, Sachs P6, Thomas C20, Tissières P8, Valla FV21, Desprez P22, Frémeaux-Bacchi V23, Varon E24, Bossuyt X25, Cohen R2, Abel L26, Casanova JL27, Puel A3, Picard C28.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.Clin Infect Dis.2014 Jul 15;59(2):244-51. doi: 10.1093/cid/ciu274. Epub 2014 Apr 23.
BACKGROUND: About 10% of pediatric patients with invasive pneumococcal disease (IPD) die from the disease. Some primary immunodeficiencies (PIDs) are known to confer predisposition to IPD. However, a systematic search for these PIDs has never been carried out in children presenting with IPD.METHODS:
PMID 24759830

Structural characterization of disease-causing mutations on SAP and the functional impact on the SLAM peptide: a molecular dynamics approach.

Chandrasekaran P1, Rajasekaran R.
Molecular bioSystems.Mol Biosyst.2014 Jul 3;10(7):1869-80. doi: 10.1039/c4mb00177j. Epub 2014 Apr 25.
X-linked lymphoproliferative (XLP) syndrome is an extremely rare inherited immunodeficiency disease characterized by severe immune dysregulation caused by mutations in signaling lymphocyte activation molecule (SLAM) associated protein (SAP) gene. The XLP syndrome was manifested due to dysfunction of
PMID 24770789

Identification of a Novel Mutation in the CYBB Gene, p.Asp378Gly, in a Patient With X-linked Chronic Granulomatous Disease.

Song SM1, Park MR2, Kim DS2, Kim J2, Kim YJ1, Ki CS3, Ahn K2.
Allergy, asthma & immunology research.Allergy Asthma Immunol Res.2014 Jul;6(4):366-9. doi: 10.4168/aair.2014.6.4.366. Epub 2014 Jan 20.
Chronic granulomatous disease (CGD) is a rare immunodeficiency disease, which is characterized by the lack of a functional nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in phagocytes. The disease presents leukocytosis, anemia, hypergammaglobulinemia, and granuloma formation of the skin
PMID 24991462

近藤元就
東邦医学会雑誌 1(1), 30-34, 2015-03
… 時にinterleukin 2 receptor gamma（IL-2Rγ）鎖cDNAがクローニングされた．その後，IL-2Rγ鎖遺伝子異常により，T，natural killer（NK）細胞欠損を特徴とする先天性免疫不全症，X-linked severe combined immunodeficiency（X-SCIDあるいはSCIDX1）が発症することが明らかになった．IL-2Rγ鎖は複数のサイトカイン受容体サブユニットとして共有されていることがこれまでに明らかとなり，現 …
NAID 120005614770

Wada Taizo,Itoh Masatsune,Maeba Hideaki,Toma Tomoko,Niida Yo,Saikawa Yutaka,Yachie Akihiro
Pediatric Blood and Cancer 61(4), 746-748, 2014-04
… X-linked thrombocytopenia (XLT) is caused by mutations in the WAS gene and characterized by thrombocytopenia with minimal or no immunodeficiency. …
NAID 120005411676

Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency

Wada Taizo,Kanegane Hirokazu,Ohta Kazuhide,Katoh Fumiyo,Imamura Toshihiko,Nakazawa Yozo,Miyashita Ritsuko,Hara Junichi,Hamamoto Kazuko,Yang Xi,Filipovich Alexandra H.,Marsh Rebecca A.,Yachie Akihiro
Cytokine 65(1), 74-78, 2014-01
… X-linked lymphoproliferative syndrome (XLP) is a rare primary immunodeficiency characterized by increased vulnerability to Epstein-Barr virus infection. … XLP type 1 is caused by mutations in SH2D1A, whereas X-linked inhibitor of apoptosis (XIAP) encoded by XIAP/BIRC4 is mutated in XLP type 2. …
NAID 120005349175