WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
tall woody perennial grasses with hollow slender stems especially of the genera Arundo and Phragmites
a vibrator consisting of a thin strip of stiff material that vibrates to produce a tone when air streams over it; "the clarinetist fitted a new reed onto his mouthpiece" (同)vibrating reed
United States journalist who reported on the October Revolution from Petrograd in 1917; founded the Communist Labor Party in America in 1919; is buried in the Kremlin in Moscow (1887-1920) (同)John Reed
United States physician who proved that yellow fever is transmitted by mosquitoes (1851-1902) (同)Walter Reed

PrepTutorEJDIC

(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
『アシ』,ヨシ;《複数形で》(屋根ふきに用いる)乾燥したアシ(ヨシ)の茎 / アシ笛,牧笛(アシなどの茎で作ったもの) / リード,舌(クラリネットやオーボエなどの吹口についている薄片) / リード楽(リードの震動で音を出す管楽器;クラリネットやオーボエなど)
rheniumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/29 07:02:03」(JST)

wiki en

Micrograph showing a classic Reed–Sternberg cell.

Micrograph showing a "popcorn cell", the Reed–Sternberg cell variant seen in nodular lymphocyte predominant Hodgkin lymphoma.H&E stain.

Reed–Sternberg cells (also known as lacunar histiocytes for certain types) are different giant cells found with light microscopy in biopsies from individuals with Hodgkin's lymphoma (aka Hodgkin's disease; a type of lymphoma). They are usually derived from B lymphocytes, classically considered crippled germinal center B cells, meaning they have not undergone hypermutation to express their antibody. Seen against a sea of B cells, they give the tissue a moth-eaten appearance.^[1]

They are named after Dorothy Reed Mendenhall and Carl Sternberg, who provided the first definitive microscopic descriptions of Hodgkin's disease.^[2]^[3]

Classification of Hodgkin's is based on the reactive cell mixture. Immunomarkers are used eg. CD 15 and 30.

Reed–Sternberg cells are large and are either multinucleated or have a bilobed nucleus with prominent eosinophilic inclusion-like nucleoli (thus resembling an "owl's eye" appearance). Reed–Sternberg cells are CD30 and CD15 positive, usually negative for CD20 and CD45. The presence of these cells is necessary in the diagnosis of Hodgkin's lymphoma – the absence of Reed–Sternberg cells has very high negative predictive value. They can also be found in reactive lymphadenopathy (such as infectious mononucleosis, carbamazepine associated lymphadenopathy) and very rarely in other types of non-Hodgkin lymphomas.

A special type of Reed–Sternberg cells (RSCs) is the lacunar histiocyte, whose cytoplasm retracts when fixed in formalin, so the nuclei give the appearance of cells that lie with empty spaces (called lacunae) between them.^[4] These are characteristic of the nodular sclerosis subtype of Hodgkin's lymphoma.^[4]

Mummified RSCs (compact nucleus, basophilic cytoplasm, no nucleolus) are also associated with classical Hodgkin's lymphoma while popcorn cells (small cell with hyper-lobulated nucleus and small nucleoli) are lymphohistiocytic (L-H) variant of Reed Sternberg cells and are associated with Nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL).

RSCs and one RSC cell line (L1236 cells) but not other RSC cell lines express very high levels of ALOX15 (i.e. 15-lipoxyenase-1), an enzyme that metabolizes arachidonic acid and various other polyunsaturated fatty acids to a wide array of bioactive products (see 15-hydroxyicosatetraenoic acid). This is unusual in that lymphocytes typically express little or no ALOX15. It is suggested that ALOX15, perhaps operating through is products such as the eoxins, contributes to the development and/or morphology of Hodgkin's lymphoma.^[5]^[6]^[7]^[8]

References

^ Hartlapp I, Pallasch C, Weibert G, Kemkers A, Hummel M, Re D (February 2009). "Depsipeptide induces cell death in Hodgkin lymphoma-derived cell lines". Leuk. Res. 33 (7): 929–36. doi:10.1016/j.leukres.2008.12.013. PMID 19233470.
^ Reed D. On the pathological changes in Hodgkin's disease, with special reference to its relation to tuberculosis. Johns Hopkins Hosp Rep 1902;10:133-96.
^ Sternberg C. Uber eine eigenartige unter dem Bilde der Pseudoleukamie verlaufende Tuberculose des lymphatischen Apparates. Ztschr Heilk 1898;19:21–90.
^ ^a ^b Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.
^ FEBS J. 2008 Aug;275(16):4222-34. doi: 10.1111/j.1742-4658.2008.06570
^ Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):120-5. doi: 10.1016/j.prostaglandins.2008.12.003
^ Exp Cell Res. 2012 Feb 1;318(3):169-76. doi: 10.1016/j.yexcr.2011.10.017
^ Exp Hematol. 2010 Feb;38(2):116-23. doi: 10.1016/j.exphem.2009

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. リードスタンバーグ細胞およびホジキンリンパ腫の病因 the reed sternberg cell and the pathogenesis of hodgkin lymphoma
2. 古典型ホジキンリンパ腫の疫学、病理学的特徴、および診断 epidemiology pathologic features and diagnosis of classical hodgkin lymphoma
3. 結節性リンパ球優位型ホジキンリンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of nodular lymphocyte predominant hodgkin lymphoma
4. 小児および思春期におけるホジキンリンパ腫の概要 overview of hodgkin lymphoma in children and adolescents
5. 血管免疫芽球性Ｔ細胞性リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of angioimmunoblastic t cell lymphoma

English Journal

High-grade myxoinflammatory fibroblastic sarcoma: a report of 23 cases.

Michal M1, Kazakov DV2, Hadravský L2, Kinkor Z2, Kuroda N2, Michal M3.
Annals of diagnostic pathology.Ann Diagn Pathol.2015 Jun;19(3):157-63. doi: 10.1016/j.anndiagpath.2015.03.012. Epub 2015 Apr 6.
We describe 23 cases of high-grade myxoinflammatory fibroblastic sarcoma (MIFS). The patients were 15 women and 8 men, with the age ranging at the time of diagnosis from 39 to 93 years (mean, 64.3 years; median, 66 years). Follow-up was available for 18 patients, of whom 9 developed metastatic disea
PMID 25886867

Tumour-associated Mast Cells in Classical Hodgkin Lymphoma: Correlation with Histological Subtype, Other Tumour-infiltrating Inflammatory Cell Subsets, and Outcome.

Andersen MD1, Kamper P1, Nielsen PS2, Bendix K2, Riber-Hansen R2, Steiniche T2, Hamilton-Dutoit S2, Clausen M1, d'Amore F1.
European journal of haematology.Eur J Haematol.2015 May 11. doi: 10.1111/ejh.12583. [Epub ahead of print]
The tumour microenvironment in classical Hodgkin lymphoma (cHL) is characterised by a minor population of neoplastic Hodgkin and Reed-Sternberg cells within a heterogeneous background of non-neoplastic bystanders cells, including mast cells. The number of infiltrating mast cells in cHL has been repo
PMID 25963595

Primary Refractory and Early-Relapsed Hodgkin Lymphoma: Strategies for Therapeutic Targeting Based on the Tumor Microenvironment.

Carbone A1, Gloghini A, Castagna L, Santoro A, Carlo-Stella C.
The Journal of pathology.J Pathol.2015 May 7. doi: 10.1002/path.4558. [Epub ahead of print]
Classical Hodgkin lymphoma (cHL), a distinct disease entity with characteristic clinical and pathologic features, accounts for approximately 10% of all malignant lymphomas. cHL can be considered a prototype model for how the tumor microenvironment influences cancer pathogenesis. Cellular components
PMID 25953622

Japanese Journal

Detection of immunoglobulin heavy-chain gene rearrangement at the single-cell level in malignant lymphomas : No rearrangement is found in Hodgkin and Sternberg-Reed cells

ROTH J
Int J Cancer 57, 799-804, 1994
NAID 80007682491

Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population

STEIN H.
Int J Cancer 30, 445-459, 1982
NAID 30025960634

悪性リンパ腫の穿刺細胞診

栗田宗次,小川一誠,蒲貞行,菱田隆子,須知泰山
日本臨床細胞学会雑誌 17(1), 47-53, 1978-01-31
NAID 110001251233

「リード・シュテルンベルグ細胞」

　　[★]

英: Reed-Sternberg cell, RS, Reed-Sternberg giant cells
同: Reed-Sternberg細胞、Reed-Sternberg巨細胞、ドロシー・リード細胞, Dorothy Reed cell, Dorothy Reed cells、ステルンベルグ巨細胞 Sternberg giant cell、ステルンベルグ-リード細胞 Sternberg-Reed cell、ステルンベルグ巨細胞 Sternberg giant cell
関: ホジキンリンパ腫、ホジキン細胞

[show details]

リード・ステンベルグ細胞 : 8 件
リード・スタンバーク細胞 : 約 0 件
リード・ステルンベルグ細胞 : 約 58 件
リード・ステルンベルク細胞 : 約 3 件
リード・シュテルンベルグ細胞 : 66 件
リード・シュテルンベルク細胞 : 80 件
リード・ステンベルグ巨細胞 : 4 件
リード・スタンバーク巨細胞 : 約 9 件
リード・ステルンベルグ巨細胞 : 36 件
リード・シュテルンベルグ巨細胞 : 5 件
リード・シュテルンベルク巨細胞 : 2 件

ホジキンリンパ腫に見られる多核で大型の細胞。

参考

1. 病理各論コア画像

http://jsp.umin.ac.jp/corepictures2007/02/c03/index.html

「Re」

　　[★]

「cell」

　　[★] 細胞　　　　　　　

[pmid19233470-1] Hartlapp I, Pallasch C, Weibert G, Kemkers A, Hummel M, Re D (February 2009). "Depsipeptide induces cell death in Hodgkin lymphoma-derived cell lines". Leuk. Res. 33 (7): 929–36. doi:10.1016/j.leukres.2008.12.013. PMID 19233470.

[2] Reed D. On the pathological changes in Hodgkin's disease, with special reference to its relation to tuberculosis. Johns Hopkins Hosp Rep 1902;10:133-96.

[3] Sternberg C. Uber eine eigenartige unter dem Bilde der Pseudoleukamie verlaufende Tuberculose des lymphatischen Apparates. Ztschr Heilk 1898;19:21–90.

[Robbins-4] Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.

[5] FEBS J. 2008 Aug;275(16):4222-34. doi: 10.1111/j.1742-4658.2008.06570

[6] Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):120-5. doi: 10.1016/j.prostaglandins.2008.12.003

[7] Exp Cell Res. 2012 Feb 1;318(3):169-76. doi: 10.1016/j.yexcr.2011.10.017

[8] Exp Hematol. 2010 Feb;38(2):116-23. doi: 10.1016/j.exphem.2009

リンク元	「リード・シュテルンベルグ細胞」
関連記事	「Re」「cell」

匿名

検索

案内

案内

Sternberg-Reed cell