シャンバーク病
WordNet
- an impairment of health or a condition of abnormal functioning
- caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
PrepTutorEJDIC
- (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
- 女性の話術芸人 =diseur
- 病気にかかった / 病的な,不健全な(morbid)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/26 16:21:46」(JST)
[Wiki en表示]
| Schamberg disease |
|
Rust-colored spots typical of Schamberg disease on the lower left leg and left foot of a 26-year-old Caucasian male.
|
| Classification and external resources |
| ICD-10 |
L81.7 |
| ICD-9 |
709.09 |
| DiseasesDB |
30753 |
| eMedicine |
derm/327 |
| Patient UK |
Schamberg disease |
| MeSH |
D010859 |
Schamberg Disease, (also known as "Progressive pigmentary dermatosis of Schamberg",[1] "Purpura pigmentosa progressiva" (PPP),[1] and "Schamberg's purpura"[1]) is a chronic discoloration of the skin found in people of all ages, usually affecting the legs. It slowly spreads throughout the body, and is most common in males.[2]:829 It is named after Jay Frank Schamberg, who described it in 1901.
Contents
- 1 Definition
- 2 Cause
- 3 Symptoms
- 4 Treatment
- 5 See also
- 6 References
Definition
Schamberg's disease, or progressive pigmented purpuric dermatitis, is a chronic discoloration of the skin which usually affects the legs and often spreads slowly. This disease is more common in males and may occur at any age from childhood onward.
Cause
Schamberg's disease is caused by leaky blood vessels near the surface of the skin, capillaries, which allow red blood cells to slip through into the skin. The red blood cells in the skin then fall apart and release their iron which causes a rust color, this accounts for the orange tint of the rash.
Symptoms
The lesions are most frequent on the lower limbs, but may occur anywhere on the body, including the hands, arms, torso and even the neck. They may vary in number and erupt in mass numbers. They consist of irregular patches of orange or brown pigmentation due to the iron complex hemosiderin, with characteristic "cayenne pepper" spots appearing within and at the edge of old lesions. There are usually no symptoms, although there may be some slight itching. The eruption may persist for many years. The pattern of the eruption changes, with slow extension and often some clearing of the original lesions.
Treatment
There is no cure for Schamberg's disease; however, the itching can be controlled by a cortisone cream, and Colchicine treatment has been successfully used to prevent recurrence of the symptoms.
See also
- Pigmentary purpuric eruptions
References
- ^ a b c Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
UpToDate Contents
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English Journal
- Lack of association between cytotoxic T-lymphocyte antigen-4+49A/G polymorphism and psoriasis and vitiligo: A meta-analysis of case-control studies.
- Liang J1, Zhang S1, Luo Q1, Li W1, Tian X1, Zhang F2, Zhao T1, Chen X1, Zhang X3.
- Gene.Gene.2015 Sep 1;568(2):196-202. doi: 10.1016/j.gene.2015.05.051. Epub 2015 May 24.
- BACKGROUND: Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a critical negative regulator of T-cell activation and proliferation. Several studies have assessed the association between CTLA-4+49A/G polymorphism and psoriasis and vitiligo, but the results are inconsistent.AIMS: This study was conducted t
- PMID 26013045
- Comparison of therapeutic effects of liposomal Tranexamic Acid and conventional Hydroquinone on melasma.
- Banihashemi M1, Zabolinejad N1, Jaafari MR2, Salehi M3,4, Jabari A1.
- Journal of cosmetic dermatology.J Cosmet Dermatol.2015 Sep;14(3):174-7. doi: 10.1111/jocd.12152. Epub 2015 Jul 14.
- BACKGROUND: Melasma is one of the most common cosmetic disorders with skin darkening. Although several treatment modalities are available, none is satisfactorily used in management of this condition. Tranexamic acid (TA), a plasmin inhibitor, is reported to improve melasma when injected locally or u
- PMID 26177992
- Inhibitory effect of 1,2,4,5-tetramethoxybenzene on mast cell-mediated allergic inflammation through suppression of IκB kinase complex.
- Je IG1, Choi HG2, Kim HH1, Lee S1, Choi JK1, Kim SW3, Kim DS3, Kwon TK4, Shin TY5, Park PH2, Khang D6, Kim SH7.
- Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2015 Sep 1;287(2):119-27. doi: 10.1016/j.taap.2015.05.006. Epub 2015 May 14.
- As the importance of allergic disorders such as atopic dermatitis and allergic asthma, research on potential drug candidates becomes more necessary. Mast cells play an important role as initiators of allergic responses through the release of histamine; therefore, they should be the target of pharmac
- PMID 25981167
Japanese Journal
- Pigmented Purpuric Dermatosis Associated with Primary Antiphospholipid Syndrome
- 苔癬型組織反応における汗腺, 汗管の病理組織学的検討
- 自家製桂枝茯苓丸が著効した Schamberg 病の1例
- 日本東洋醫學雜誌 = Japanese journal of oriental medicine 61(7), 924-929, 2010-11-20
- NAID 10026966791
Related Links
- Schamberg Disease, (also known as "Progressive pigmentary dermatosis of Schamberg," [1] "Purpura pigmentosa progressiva," [1] and "Schamberg's purpura" [1]) is a chronic discoloration of the skin found in people of all ages ...
- Dermnet.com and the Dermnet Skin Disease Atlas are to be used only as a reference. Dermnet does not provide medical advice, diagnosis or treatment.
★リンクテーブル★
[★]
- 英
- Schamberg's disease, Schamberg disease
- 同
- Schamberg病、慢性進行性色素性皮膚症 chronic progressive pigmentary dermatosis、進行性色素性皮膚症 progressive pigmentary dermatosis
- 関
- 色素異常症、、色素欠乏性色素失調症、ヘモジデリン沈着症、incontinentia pigmenti achromians、pigmentation disorder
[show details]
参考
- 1. PIGMENTED PURPURIC ERUPTION -OMIM
- http://www.ncbi.nlm.nih.gov/omim?term=Schamberg's disease
[★]
- 疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)
- 特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)
- something that is very wrong with people's attitudes, way of life or with society.
- 関
- ail、ailment、disease entity、disorder、ill、illness、malady、sick、sickness
- disease ≠ illness ≠ disorder