WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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Beà S, Valdés-Mas R, Navarro A, Salaverria I, Martín-Garcia D, Jares P, Giné E, Pinyol M, Royo C, Nadeu F, Conde L, Juan M, Clot G, Vizán P, Di Croce L, Puente DA, López-Guerra M, Moros A, Roue G, Aymerich M, Villamor N, Colomo L, Martínez A, Valera A, Martín-Subero JI, Amador V, Hernández L, Rozman M, Enjuanes A, Forcada P, Muntañola A, Hartmann EM, Calasanz MJ, Rosenwald A, Ott G, Hernández-Rivas JM, Klapper W, Siebert R, Wiestner A, Wilson WH, Colomer D, López-Guillermo A, López-Otín C, Puente XS, Campo E.SourceInstitut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Universitat de Barcelona, 08036 Barcelona, Spain.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2013 Nov 5;110(45):18250-5. doi: 10.1073/pnas.1314608110. Epub 2013 Oct 21.
Mantle cell lymphoma (MCL) is an aggressive tumor, but a subset of patients may follow an indolent clinical course. To understand the mechanisms underlying this biological heterogeneity, we performed whole-genome and/or whole-exome sequencing on 29 MCL cases and their respective matched normal DNA,
PMID 24145436

The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.

Ortica S, Tarantino N, Aulner N, Israël A, Gupta-Rossi N.Source*Unité de Signalisation Moléculaire et Activation Cellulaire, Unité de Recherche Associée (URA) 2582, Centre National de la Recherche Scientifique (CNRS), and †Imagopole, Institut Pasteur, Paris, France; and.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.FASEB J.2013 Oct 21. [Epub ahead of print]
The Notch signaling pathway is involved in liver development and regeneration. Here, we investigate the role of the 4 mammalian Notch paralogs in the regulation of hepatoblast proliferation and hepatocytic differentiation. Our model is based on bipotential mouse embryonic liver (BMEL) progenitors th
PMID 24145721

Mosaic small supernumerary marker chromosome 1 at amniocentesis: prenatal diagnosis, molecular genetic analysis and literature review.

Chen CP, Chen M, Su YN, Huang JP, Chern SR, Wu PS, Su JW, Chang SP, Chen YT, Lee CC, Chen LF, Pan CW, Wang W.SourceDepartment of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan; Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan; Department of Biotechnology, Asia University, Taichung, Taiwan; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; Institute of Clinical and Community Health Nursing, National Yang-Ming University, Taipei, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address: cpc_mmh@yahoo.com.
Gene.Gene.2013 Oct 15;529(1):169-75. doi: 10.1016/j.gene.2013.07.048. Epub 2013 Aug 7.
We present prenatal diagnosis and molecular cytogenetic analysis of mosaic small supernumerary marker chromosome 1 [sSMC(1)]. We review the literature of sSMC(1) at amniocentesis and chromosome 1p21.1-p12 duplication syndrome. We discuss the genotype-phenotype correlation of the involved genes of AL
PMID 23933412

Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine

Sakata-Yanagimoto Mamiko,Sakai Toru,Miyake Yasuyuki,Saito Toshiki I.,Maruyama Haruhiko,Morishita Yasuyuki,Nakagami-Yamaguchi Etsuko,Kumano Keiki,Yagita Hideo,Fukayama Masashi,Ogawa Seishi,Kurokawa Mineo,Yasutomo Koji,Chiba Shigeru,坂田（柳元）麻実子,千葉滋
Blood 117(1), 128-134, 2011-01-00
… Notch receptor-mediated signaling is involved in developmental process and functional modulation of lymphocytes, as well as mast cell differentiation. … Mast cells were rarely found in the small intestine of wild-type C57BL/6 mice, while abnormally accumulated in the lamina propria of the small intestinal mucosa of the Notch2 conditional knockout mice in naive status. …
NAID 120002836909

Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma

Lee Suk-young,Kumano Keiki,Nakazaki Kumi,Sanada Masashi,Matsumoto Akihiko,Yamamoto Go,Nannya Yasuhito,Suzuki Ritsuro,Ota Satoshi,Ota Yasunori,Izutsu Koji,Sakata-Yanagimoto Mamiko,Hangaishi Akira,Yagita Hideo,Fukayama Masashi,Seto Masao,Kurokawa Mineo,Ogawa Seishi,Chiba Shigeru,坂田（柳元）麻実子,千葉滋
Cancer science 100(5), 920-926, 2009-05-10
… Signaling through the Notch1 receptor has a pivotal role in early thymocyte development. … Notch2, another member of the Notch gene family, is preferentially expressed in mature B cells and is essential for marginal zone B-cell generation. … Here, we report that 5 of 63 (~8%) diffuse large B-cell lymphomas, a subtype of mature B-cell lymphomas, have Notch2 mutations. …
NAID 10025145854