関: H-ras gene、H-ras oncogene、Ha-ras gene、Ha-ras oncogene、K-ras gene、K-ras oncogene、Ki-ras gene、Ki-ras oncogene、N-ras oncogene、ras gene、ras oncogene

WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
the 14th letter of the Roman alphabet (同)n
informal term for information; "give me the gen on your new line of computers"

PrepTutorEJDIC

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 大腸癌の分子遺伝学 molecular genetics of colorectal cancer
2. 黒色腫（メラノーマ）の分子生物学 the molecular biology of melanoma
3. 甲状腺結節および非髄様甲状腺癌におけるオンコジーンおよび腫瘍抑制遺伝子 oncogenes and tumor suppressor genes in thyroid nodules and nonmedullary thyroid cancer
4. 濾胞性甲状腺癌の概要 overview of follicular thyroid cancer
5. 低身長の原因 causes of short stature

Oncogenic mutations in extramammary Paget's disease and their clinical relevance.

Kang Z, Xu F, Zhang QA, Wu Z, Zhang X, Xu J, Luo Y, Guan M.SourceDepartment of Laboratory Medicine, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai 200040, People's Republic of China.
International journal of cancer. Journal international du cancer.Int J Cancer.2013 Feb 15;132(4):824-31. doi: 10.1002/ijc.27738. Epub 2012 Aug 7.
Extramammary Paget's disease (EMPD) is a rare cutaneous malignant neoplasm. The genetic alterations underlying its pathogenesis have less been described. Therefore, we analyzed the possible mutations in the KRAS, HRAS, NRAS, BRAF, ARAF, RAF1, PIK3CA, AKT1, CTNNB1 and APC genes as well as methylation
PMID 22821211

Mitogen-activated protein kinase (MEK/ERK) inhibition sensitizes cancer cells to centromere-associated protein E inhibition.

Mayes PA, Degenhardt YY, Wood A, Toporovskya Y, Diskin SJ, Haglund E, Moy C, Wooster R, Maris JM.SourceDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA; Department of Pediatrics, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
International journal of cancer. Journal international du cancer.Int J Cancer.2013 Feb 1;132(3):E149-57. doi: 10.1002/ijc.27781. Epub 2012 Sep 28.
Inhibition of centromere-associated protein-E (CENP-E) has demonstrated preclinical anti-tumor activity in a number of tumor types including neuroblastoma. A potent small molecule inhibitor of the kinesin motor activity of CENP-E has recently been developed (GSK923295). To identify an effective drug
PMID 22948716

Identification of novel driver tumor suppressors through functional interrogation of putative passenger mutations in colorectal cancer.

Zhang L, Komurov K, Wright WE, Shay JW.SourceDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX.
International journal of cancer. Journal international du cancer.Int J Cancer.2013 Feb 1;132(3):732-7. doi: 10.1002/ijc.27705. Epub 2012 Jul 21.
Cancer genome sequencing efforts are leading to the identification of genetic mutations in many types of malignancy. However, the majority of these genetic alterations have been considered random passengers that do not directly contribute to tumorigenesis. We have previously conducted a soft agar-ba
PMID 22753261

Effect of common B-RAF and N-RAS mutations on global gene expression in melanoma cell lines

杉山武敏,逢坂光彦
日本疾患モデル学会記録 21, 37-44, 2005
… Almost 30% of DMBA- and 16% of TMBA-induced leukemia reveal total or partial trisomy of #2 chromosome (+2 and 2q+, respectively) and many of the rest have normal diploid (2n) karyotype. … Most of these leukemias are erythroblastic leukemia and they reveal a specific mutation of N-ras gene (A → T transversion at the second base of colon 61) . …
NAID 130000760629

鶴見茂治
Dokkyo journal of medical sciences 30(1), 119-124, 2003-03-25
… 加症(polycythemia vera: PV),本態性血小板血症(essential thrombocythemia : ET) ,原発性骨髄線維症(idiopathic myelofibro-sis : MF)が含まれ,骨髄系細胞の慢性的な増殖を主徴とするが,その発症や病期進展に関与する分子病態については未だ不明の点が多い.我々は,本邦のMPD64症例(PV15例,ET38例,MF11例;慢性期例計58例,白血病化例計6例)につき,造血器腫瘍で多く変異がみられるN-rasおよびp53遺伝子の変異についての解析を行った。 …
NAID 110000008692

英: ras gene
関: H-ras gene、H-ras oncogene、Ha-ras gene、Ha-ras oncogene、K-ras gene、K-ras oncogene、Ki-ras gene、Ki-ras oncogene、N-ras gene、N-ras oncogene、ras oncogene

英: N-ras gene
関: K-ras遺伝子、H-ras遺伝子、ras遺伝子、K-ras癌遺伝子、H-ras癌遺伝子、Ha-ras遺伝子、Ha-ras癌遺伝子、Ki-ras遺伝子、Ki-ras癌遺伝子、ras癌遺伝子、N-ras癌遺伝子

関: H-ras oncogene、Ha-ras gene、Ha-ras oncogene、K-ras gene、K-ras oncogene、Ki-ras gene、Ki-ras oncogene、N-ras gene、N-ras oncogene、ras gene、ras oncogene