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English Journal

Adenosine transport blockade restores attenuated cardioprotective effects of adenosine preconditioning in the isolated diabetic rat heart: potential crosstalk with opioid receptors.

Sharma NK, Mahadevan N, Balakumar P.SourceCardiovascular Pharmacology Division, Department of Pharmacology, Rajendra Institute of Technology and Sciences, Sirsa, 125 055, India.
Cardiovascular toxicology.Cardiovasc Toxicol.2013 Mar;13(1):22-32. doi: 10.1007/s12012-012-9182-y.
Considering the reduced ability of cardiac fibroblasts to release adenosine and increased ability of interstitial adenosine uptake during diabetes mellitus, the present study investigated the effect of adenosine preconditioning and the existence of cross-talk with opioid receptor activation in the d
PMID 22948709

Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction.

Montecucco F, Bauer I, Braunersreuther V, Bruzzone S, Akhmedov A, Lüscher TF, Speer T, Poggi A, Mannino E, Pelli G, Galan K, Bertolotto M, Lenglet S, Garuti A, Montessuit C, Lerch R, Pellieux C, Vuilleumier N, Dallegri F, Mage J, Sebastian C, Mostoslavsky R, Gayet-Ageron A, Patrone F, Mach F, Nencioni A.Source1 Division of Cardiology, Foundation for Medical Researches, Faculty of Medicine, Department of Internal Medicine, Geneva University Hospitals , Geneva, Switzerland .
Antioxidants & redox signaling.Antioxid Redox Signal.2013 Feb 20;18(6):630-41. doi: 10.1089/ars.2011.4487. Epub 2012 May 14.
Abstract Aims: Nicotinamide phosphoribosyltransferase (Nampt) is a key enzyme for nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, and recent evidence indicates its role in inflammatory processes. Here, we investigated the potential effects of pharmacological Nampt inhibition with FK866 in
PMID 22452634

Ventricular arrhythmogenesis following slowed conduction in heptanol-treated, Langendorff-perfused mouse hearts

Direct Effects of Esmolol and Landiolol on Cardiac Function, Coronary Vasoactivity, and Ventricular Electrophysiology in Guinea-Pig Hearts

SHIBATA Shigehiro,OKAMOTO Yosuke,ENDO Shigeatsu,ONO Kyoichi
Journal of pharmacological sciences 118(2), 255-265, 2012-02-20
… The current study utilized the Langendorff perfused heart system to measure changes in cardiac function and hemodynamics in response to each drug. …
NAID 10030455076