WordNet

first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
a unit of force equal to the force exerted by gravity; used to indicate the force to which a body is subjected when it is accelerated (同)gee, g-force
the 7th letter of the Roman alphabet (同)g
any high mountain

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1. まれな先天性副腎過形成 uncommon congenital adrenal hyperplasias
2. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
3. α-1アンチトリプシン欠乏の治療 treatment of alpha 1 antitrypsin deficiency
4. ステロイド5 -α-レダクターゼ2欠乏症 steroid 5 alpha reductase 2 deficiency
5. αサラセミアの病態生理 pathophysiology of alpha thalassemia

Identification and subcellular localization of molecular complexes of Gq/11α protein in HEK293 cells.

Drastichova Z1, Novotny J.
Acta biochimica et biophysica Sinica.Acta Biochim Biophys Sin (Shanghai).2012 Aug;44(8):641-9. doi: 10.1093/abbs/gms050. Epub 2012 Jun 17.
Heterotrimeric G-proteins localized in the plasma membrane convey the signals from G-protein-coupled receptors (GPCRs) to different effectors. At least some types of G-protein α subunits have been shown to be partly released from plasma membranes and to move into the cytosol after receptor activati
PMID 22710260

Protein alterations induced by long-term agonist treatment of HEK293 cells expressing thyrotropin-releasing hormone receptor and G11alpha protein.

Drastichova Z1, Bourova L, Hejnova L, Jedelsky P, Svoboda P, Novotny J.
Journal of cellular biochemistry.J Cell Biochem.2010 Jan 1;109(1):255-64. doi: 10.1002/jcb.22409.
This study aimed to determine whether sustained stimulation with thyrotropin-releasing hormone (TRH), a peptide with important physiological functions, can possibly affect expression of plasma membrane proteins in HEK293 cells expressing high levels of TRH receptor and G(11)alpha protein. Our previo
PMID 19911373

Ca2+ responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G11alpha protein overexpression on homologous and heterologous desensitization.

Ostasov P1, Krusek J, Durchankova D, Svoboda P, Novotny J.
Cell biochemistry and function.Cell Biochem Funct.2008 Mar-Apr;26(2):264-74.
The molecular mechanisms involved in GPCR-initiated signaling cascades where the two receptors share the same signaling cascade, such as thyrotropin-releasing hormone (TRH) and angiotensin II (ANG II), are still far from being understood. Here, we analyzed hormone-induced Ca(2+) responses and the pr
PMID 18041110