English Journal

A rat model of intravesical delivery of small interfering RNA for studying urinary carcinoma.

Arum CJ1, Kodama Y, Rolim N, Widerøe M, Anderssen E, Viset T, Otterlei M, Lundgren S, Chen D, Zhao CM.
World journal of urology.World J Urol.2010 Aug;28(4):479-85. doi: 10.1007/s00345-010-0542-6. Epub 2010 Apr 8.
PURPOSE: siRNA has been used successfully in loss-of-function studies in vitro, but neither in vivo nor in clinical applications. The aims of the present study were (1) to establish rat models for in vivo delivery of siRNA to bladder cancer, and (2) to identify potential targets for siRNA.METHODS: T
PMID 20376453

[Etiopathology, risk factors, environmental influences and epidemiology of bladder cancer].

Kälble T1.
Der Urologe. Ausg. A.Urologe A.2001 Nov;40(6):447-50.
The etiology of bladder cancer is well investigated. Bladder carcinogenicity of nitrosamines is proven in animals but not in men, although dimethylnitrosamine in urine of patients with urinary infections or bilharziosis suggest a causative role. Aromatic amines are strong bladder carcinogens. Arsen
PMID 11760347

Prevention of bladder tumor formation in mice by a novel bone marrow-derived factor, reptimed.

Khandaker MH1, Kadhim SA, Ichim TE, Howson-Jan K, Chin J, Singhal SK.
Anticancer research.Anticancer Res.2000 Jan-Feb;20(1A):183-9.
BACKGROUND: Reptimed is a novel, species-conserved, bone marrow-derived molecule which possesses anti-neoplastic activity. Previously, we established an orthotopic murine bladder tumor (MBT-2) model and reported accurate documentation of the presence and the extent of intravesical involvement of bla
PMID 10769653