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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/18 07:25:13」(JST)
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5-Formamidoimidazole-4-carboxamide ribotide
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| Names |
| IUPAC name
[(2R,3S,4R,5R)-5-(4-Carbamoyl-5-formamidoimidazol-1-yl)- 3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
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| Other names
5-Formamidoimidazole-4-carboxamide ribonucleotide,
FAICAR
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| Identifiers |
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CAS Number
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13018-54-7 N |
| ChEBI |
CHEBI:18381 Y |
| ChEMBL |
ChEMBL521310 Y |
| ChemSpider |
145893 Y |
| Jmol 3D model |
Interactive image
Interactive image |
| MeSH |
5-formamidoimidazole-4-carboxamide+ribotide |
| PubChem |
166760 |
InChI
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InChI=1S/C10H15N4O9P/c11-8(18)5-9(13-3-15)14(2-12-5)10-7(17)6(16)4(23-10)1-22-24(19,20)21/h2-4,6-7,10,16-17H,1H2,(H2,11,18)(H,13,15)(H2,19,20,21)/t4-,6-,7-,10-/m1/s1 Y
Key: ABCOOORLYAOBOZ-KQYNXXCUSA-N Y
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InChI=1/C10H15N4O9P/c11-8(18)5-9(13-3-15)14(2-12-5)10-7(17)6(16)4(23-10)1-22-24(19,20)21/h2-4,6-7,10,16-17H,1H2,(H2,11,18)(H,13,15)(H2,19,20,21)/t4-,6-,7-,10-/m1/s1
Key: ABCOOORLYAOBOZ-KQYNXXCUBS
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SMILES
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C1=NC(=C(N1[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O)NC=O)C(=O)N
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O=P(O)(O)OC[C@H]2O[C@@H](n1cnc(C(=O)N)c1NC=O)[C@H](O)[C@@H]2O
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| Properties |
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Chemical formula
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C10H15N4O9P |
| Molar mass |
366.22 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| N verify (what is YN ?) |
| Infobox references |
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5-Formamidoimidazole-4-carboxamide ribotide (or FAICAR) is an intermediate in the formation of purines. It is formed by the enzyme AICAR transformylase from AICAR and 10-formyltetrahydrofolate.
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Nucleotide metabolic intermediates
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| Purine metabolism |
| Anabolism |
| R5P→IMP: |
- R5P
- PRPP
- PRA
- GAR
- FGAR
- FGAM
- AIR
- CAIR
- SAICAR
- AICAR
- FAICAR
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| IMP→AMP: |
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| IMP→GMP: |
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| Catabolism |
- Hypoxanthine
- Xanthine
- Uric acid
- 5-Hydroxyisourate
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| Pyrimidine metabolism |
| Anabolism |
- Carbamoyl phosphate
- Carbamoyl aspartic acid
- 4,5-Dihydroorotic acid
- Orotic acid
- Orotidine 5'-monophosphate
- Uridine monophosphate
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| Catabolism |
| uracil: |
- Dihydrouracil
- 3-Ureidopropionic acid
- β-Alanine
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| thymine: |
- Dihydrothymine
- β-Ureidoisobutyric acid
- 3-Aminoisobutyric acid
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English Journal
- Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
- Zhang Y, White RH, Ealick SE.SourceDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853-1301, USA.
- Biochemistry.Biochemistry.2008 Jan 8;47(1):205-17. Epub 2007 Dec 11.
- Purine biosynthesis requires 10 enzymatic steps in higher organisms, while prokaryotes require an additional enzyme for step 6. In most organisms steps 9 and 10 are catalyzed by the purH gene product, a bifunctional enzyme with both 5-formaminoimidazole-4-carboxamide ribonucleotide (FAICAR) synthase
- PMID 18069798
Related Links
- Chiamaci subito! | Tel 022547075 - 022533165 Fax 0227301387 | P.iva 03685770962 | Privacy Policy | info@faicar.it
- FAICAR 5-form-aminoimidazole-4-carboxamide ribonucleotide Note: Acronym Finder has no verified definitions for FAICAR
Related Pictures
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[★]
- 英
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- 関
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- 同
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