クラブトリー効果
WordNet
- act so as to bring into existence; "effect a change"
- a symptom caused by an illness or a drug; "the effects of sleep loss"; "the effect of the anesthetic"
- (of a law) having legal validity; "the law is still in effect" (同)force
- the central meaning or theme of a speech or literary work (同)essence, burden, core, gist
- an impression (especially one that is artificial or contrived); "he just did it for effect"
- produce; "The scientists set up a shock wave" (同)effectuate, set_up
- property of a personal character that is portable but not used in business; "she left some of her personal effects in the house"; "I watched over their effects until they returned" (同)personal_effects
PrepTutorEJDIC
- 〈C〉〈U〉『結果』 / 〈C〉〈U〉(…への)『効果』,効きめ,影響《+『on』(『upon』)+『名』》 / 〈C〉(色・音・形などの)印象,感銘 / 《複数形で》品物;身の回り品;動産,財産 / (結果として)…‘を'『もたらす』;〈目的など〉‘を'果たす,遂行する
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/13 17:27:21」(JST)
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See also: Evolution of aerobic fermentation
Named after the English biochemist Herbert Grace Crabtree, the Crabtree effect describes the phenomenon whereby the yeast, Saccharomyces cerevisiae, produces ethanol (alcohol) in aerobic conditions and high external glucose concentrations rather than producing biomass via the tricarboxylic acid (TCA) cycle, the usual process occurring aerobically in most yeasts e.g. Kluyveromyces spp[1]. This phenomenon is observed in most species of the Saccharomyces, Schizosaccharomyces, Debaryomyces, Brettanomyces, Torulopsis, Nematospora, and Nadsonia genera.[2] Increasing concentrations of glucose accelerates glycolysis (the breakdown of glucose) which results in the production of appreciable amounts of ATP through substrate-level phosphorylation. This reduces the need of oxidative phosphorylation done by the TCA cycle via the electron transport chain and therefore decreases oxygen consumption. The phenomenon is believed to have evolved as a competition mechanism (due to the antiseptic nature of ethanol) around the time when the first fruits on Earth fell from the trees.[1] The crabtree effect works by repressing respiration by the fermentation pathway, dependent on the substrate.[2]
References
- ^ a b Thomson JM, Gaucher EA, Burgan MF, De Kee DW, Li T, Aris JP, Benner SA. (2005). "Resurrecting ancestral alcohol dehydrogenases from yeast.". Nat. Genet. 37 (6): 630–635. doi:10.1038/ng1553. PMID 15864308.
- ^ a b De Deken, R. H. (1966). "The Crabtree Effect: A Regulatory System in Yeast". J. gen. Microbiol. PMID 5969497.
Further reading
- Crabtree HG (1928). "The carbohydrate metabolism of certain pathological overgrowths.". Biochem J. 22 (5): 1289–98. PMC 1252256. PMID 16744142.
UpToDate Contents
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English Journal
- The Hawthorne effect in direct observation research with physicians and patients.
- Goodwin MA1, Stange KC2, Zyzanski SJ3, Crabtree BF4, Borawski EA5, Flocke SA6.
- Journal of evaluation in clinical practice.J Eval Clin Pract.2017 Jul 28. doi: 10.1111/jep.12781. [Epub ahead of print]
- PMID 28752911
- Quantitative metabolomics of a xylose-utilizing Saccharomyces cerevisiae strain expressing the Bacteroides thetaiotaomicron xylose isomerase on glucose and xylose.
- Mert MJ1, Rose SH2, la Grange DC1, Bamba T3, Hasunuma T4, Kondo A3, van Zyl WH5.
- Journal of industrial microbiology & biotechnology.J Ind Microbiol Biotechnol.2017 Jul 25. doi: 10.1007/s10295-017-1969-1. [Epub ahead of print]
- PMID 28744577
- Immunologic response to vaccine challenge in pregnant PTPN22 R620W carriers and non-carriers.
- Tien SH1, Crabtree JN2, Gray HL1, Peterson EJ2.
- PloS one.PLoS One.2017 Jul 19;12(7):e0181338. doi: 10.1371/journal.pone.0181338. eCollection 2017.
- PMID 28723925
Japanese Journal
- ¹³C-metabolic flux analysis in S-adenosyl-L-methionine production by Saccharomyces cerevisiae
- 3P-061 好気・低濃度グルコース条件下におけるSaccharomyces cerevisiaeの転写解析(発酵生理学,発酵工学,一般講演)
- ¹³C-based metabolic flux analysis of Saccharomyces cerevisiae with a reduced Crabtree effect
Related Links
- ef·fect (ĭ-fĕkt′) n. 1. Something brought about by a cause or agent; a result. 2. The power to produce an outcome or achieve a result: The government's action had little effect on the trade imbalance. 3. Advantage; avail: used her ...
- The inhibition of oxygen consumption by adding glucose to microorganisms that have a high rate of aerobic glycolysis, which also occurs in most malignancies; the converse of the Pasteur effect effect [ĕ-fekt´] a result produced by an ...
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- 英
- Crabtree effect
- 同
- 逆パストゥール効果 reverse Pasteur effect
- 関
- パストゥール効果
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- (変化などを)もたらす。(目的・計画など)果たす、遂げる。実施/施行する
- 関
- act, action, affect, efficacy, impact, impinge, indication, influence, potency, effected
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- 関
- effect