WordNet

immunogen consisting of a suspension of weakened or dead pathogenic cells injected in order to stimulate the production of antibodies (同)vaccinum
an aerobic Gram-negative coccobacillus that causes brucellosis; can be used as a bioweapon

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牛痘種,痘苗(牛痘を起こすビールスで,天然痘予防のために人体に接種される) / (伝染病の病原菌から作った)ワクチン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/12 19:22:41」(JST)

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Brucellosis vaccine is a vaccine for cattle, sheep and goats used against brucellosis.^[1]^[2]

Currently, there is no vaccine available for humans.^[3]

References

^ Ko J, Splitter GA (January 2003). "Molecular Host-Pathogen Interaction in Brucellosis: Current Understanding and Future Approaches to Vaccine Development for Mice and Humans". Clin. Microbiol. Rev. 16 (1): 65–78. doi:10.1128/CMR.16.1.65-78.2003. PMC 145300. PMID 12525425.
^ Brucella vaccine at the US National Library of Medicine Medical Subject Headings (MeSH)
^ Marta A. Guerra, Barun K. De. "Brucellosis". Centers for Disease Control and Prevention. Retrieved 15 May 2013.

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1. ブルセラ症の臨床症状、診断、および治療 clinical manifestations diagnosis and treatment of brucellosis
2. ブルセラ菌の微生物学、疫学、および病因 microbiology epidemiology and pathogenesis of brucella
3. 犬および猫以外のペットからの人畜共通感染症 zoonoses from pets other than dogs and cats
4. 帰国高齢者に対する医療 medical care of the returning veteran
5. 犬からの人畜共通感染症 zoonoses from dogs

English Journal

Investigating the Use of Protein Saver Cards for Storage and Subsequent Detection of Bovine Anti-Brucella abortus Smooth Lipopolysaccharide Antibodies and Gamma Interferon.

Duncombe L, Commander NJ, Erdenlig S, McGiven JA, Stack J.SourceAnimal Health and Veterinary Laboratories Agency, Weybridge, Surrey, United Kingdom.
Clinical and vaccine immunology : CVI.Clin Vaccine Immunol.2013 Nov;20(11):1669-74. doi: 10.1128/CVI.00033-13. Epub 2013 Aug 28.
Brucella abortus, a smooth strain of the genus Brucella, is the causative agent of bovine brucellosis. To support the ongoing development of diagnostic tests for bovine brucellosis, the use of Protein Saver cards (Whatman) for bovine blood serum and plasma sample collection has been evaluated. These
PMID 23986318

Deletion of the GI-2 integrase and the wbkA flanking transposase improves the stability of Brucella melitensis Rev 1 vaccine.

Mancilla M, Grilló MJ, de Miguel MJ, López-Goñi I, San-Román B, Zabalza-Baranguá A, Moriyón I.AbstractBrucella melitensis Rev 1 is the best vaccine available for the prophylaxis of small ruminant brucellosis and, indirectly, for reducing human brucellosis. However, Rev 1 shows anomalously high rates of spontaneous dissociation from smooth (S) to rough (R) bacteria, the latter being inefficacious as vaccines. This S-R instability results from the loss of the O-polysaccharide. To overcome this problem, we investigated whether some recently described mechanisms promoting mutations in O-polysaccharide genes were involved in Rev 1 S-R dissociation. We found that a proportion of Rev 1 R mutants result from genome rearrangements affecting the wbo O-polysaccharide loci of genomic island GI-2 and the wbkA O-polysaccharide glycosyltransferase gene of the wbk region. Accordingly, we mutated the GI-2 int gene and the wbk IS transposase involved in those arrangements, and found that these Rev 1 mutants maintained the S phenotype and showed lower dissociation levels. Combining these two mutations resulted in a strain (Rev 2) displaying a 95% decrease in dissociation with respect to parental Rev 1 under conditions promoting dissociation. Rev 2 did not differ from Rev 1 in the characteristics used in Rev 1 typing (growth rate, colonial size, reactivity with O-polysaccharide antibodies, phage, dye and antibiotic susceptibility). Moreover, Rev 2 and Rev 1 showed similar attenuation and afforded similar protection in the mouse model of brucellosis vaccines. We conclude that mutations targeting genes and DNA sequences involved in spontaneous O-polysaccharide loss enhance the stability of a critical vaccine phenotype and complement the empirical stabilization precautions taken during S Brucella vaccine production.
Veterinary research.Vet Res.2013 Oct 31;44(1):105. [Epub ahead of print]
Brucella melitensis Rev 1 is the best vaccine available for the prophylaxis of small ruminant brucellosis and, indirectly, for reducing human brucellosis. However, Rev 1 shows anomalously high rates of spontaneous dissociation from smooth (S) to rough (R) bacteria, the latter being inefficacious as
PMID 24176078