English Journal

Tan Y, Zhang Q, Wong SG, Hua Q1.
Current topics in medicinal chemistry.Curr Top Med Chem.2016;16(5):549-57.
γ-secretase is a membrane-embedded aspartyl protease carrying out cleavage of more than 100 single transmembrane-spanning proteins, including APP, Notch, N-cadherin, etc. Its subunit, presenilin (PS) is the catalytic component, of which mutations are a major cause of early onset familial Alzheimer
PMID 26268329

Yeast as a Model for Studies on Aβ Aggregation Toxicity in Alzheimer's Disease, Autophagic Responses, and Drug Screening.

Porzoor A1, Macreadie I.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1303:217-26. doi: 10.1007/978-1-4939-2627-5_12.
The Aβ peptide is widely considered a major cause of Alzheimer's disease since it causes neuronal death in an oligomerisation-dependent manner. In order to identify new inhibitors of Aβ that may be chemo preventative for Alzheimer's disease, a yeast assay that qualitatively determines the amounts
PMID 26235069

Bu XL1, Yao XQ1, Jiao SS1, Zeng F1, Liu YH1, Xiang Y1, Liang CR1, Wang QH1, Wang X1, Cao HY1, Yi X1, Deng B1, Liu CH1, Xu J1, Zhang LL1, Gao CY1, Xu ZQ1, Zhang M1, Wang L1, Tan XL2, Xu X3, Zhou HD1, Wang YJ1.
European journal of neurology.Eur J Neurol.2015 Dec;22(12):1519-25. doi: 10.1111/ene.12477. Epub 2014 Jun 9.
BACKGROUND AND PURPOSE: Previous studies suggested that the overall burden of prior infections contributes to cardiovascular diseases and stroke. In the present study, the association between infectious burden (IB) and Alzheimer's disease (AD) was examined.METHODS: Antibody titers to common infectio
PMID 24910016