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a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
(virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus
malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood

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ビールス,ろ過性病原体
白血病

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/23 18:38:54」(JST)

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The Abelson murine leukemia virus (Ab-MLV or A-MuLV) is a retrovirus (Class VI) used to induce transformation of murine lymphoid cells. As a retrovirus, it has a single-stranded, positive sense RNA genome which replicates via a DNA intermediate mediated by a reverse transcriptase. The Abelson murine leukemia virus is named for the American pediatrician Herbert T. Abelson, who first described and isolated it.^[1]

A-MuLV causes a rapidly progressive lymphosarcoma known as Abelson disease in mice, which is a type of leukemia that does not involve the thymus. However, this is only possible when the host cell is co-infected with a helper virus which provides functions it needs to be able to replicate which it does not code for in its own genome such as a reverse transcriptase and some major structural proteins. As such, A-MuLV can be described as a dependovirus. A highly efficient helper virus commonly used when growing A-MuLV in vitro is Moloney murine leukemia virus (M-MuLV). It causes leukemia directly by interfering with the normal growth and differentiation processes of lymphocytes. It can infect B-cells which was shown by the fact that some tumor cells can be seen to have immunoglobulins (Ig) on their surface although most tumor cells do not have characteristic receptors on their surface indicating that they are undifferentiated cells. In vitro studies have shown that lymphocyte infection produces tumor cell populations comprising three types of cells: stable productive cells, non-productive cells and cells which produced defective virus particles which are not infective.^[2]^[3]

References

^ Abelson, H.T. and Rabstein, L.S.; "Lymphosarcoma: virus-induced thymic-independent disease in mice"; Cancer Res.1970; 30:2213-2222.
^ Rosenberg, N., Baltimore, D. and Scher, C.D.; "In vitro Transformation of Lymphoid Cells by Abelson Murine Leukemia Virus"; 1975; Proc. Nat. Acad. Sci. USA; 72(5):1932-1936
^ Shields, A., Rosenberg, N. and Baltimore, D.; "Virus Production by Abelson Murine Leukemia Virus-Transformed Lymphoid Cells"; 1979; Journal of Virology; 31(2):557-567

External links

Abelson murine leukemia virus at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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1. 慢性骨髄性白血病の分子遺伝学 molecular genetics of chronic myeloid leukemia
2. 成人T細胞性白血病/リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of adult t cell leukemia lymphoma
3. 大顆粒T細胞リンパ球性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of t cell large granular lymphocyte leukemia
4. リンパ球増加症またはリンパ球減少症を有する患者へのアプローチ approach to the patient with lymphocytosis or lymphocytopenia
5. 有毛細胞白血病の臨床的特徴および診断 clinical features and diagnosis of hairy cell leukemia

English Journal

Involvement of miR-196a in HIV-associated neurocognitive disorders.

Bagashev A1, Mukerjee R, Santerre M, Del Carpio-Cano FE, Shrestha J, Wang Y, He JJ, Sawaya BE.
Apoptosis : an international journal on programmed cell death.Apoptosis.2014 Aug;19(8):1202-14. doi: 10.1007/s10495-014-1003-2.
Involvement of the human immunodeficiency virus type 1 (HIV-1) trans-activator of transcription (Tat) protein in neuronal deregulation and in the development of HIV-1 associated neurocognitive disorders (HAND) has been amply explored; however the mechanisms involved remain unclear. In search for the
PMID 24872081

CIP2A is overexpressed and involved in the pathogenesis of chronic myelocytic leukemia by interacting with breakpoint cluster region-Abelson leukemia virus.

Wang J1, Huang T, Sun J, Yu Y, Liu Z, Li W, Jia J, Chen C.
Medical oncology (Northwood, London, England).Med Oncol.2014 Aug;31(8):112. doi: 10.1007/s12032-014-0112-7. Epub 2014 Jul 15.
To detect the expression of cancerous inhibitor of phosphatase 2A (CIP2A) in chronic myelocytic leukemia (CML) and investigate the mechanism underlying CIP2A knockdown-mediated cell proliferation and apoptosis as well as the interaction of CIP2A with breakpoint cluster region-Abelson leukemia virus
PMID 25023053

Epigenetic alterations induced by ambient particulate matter in mouse macrophages.

Miousse IR1, Chalbot MC, Aykin-Burns N, Wang X, Basnakian A, Kavouras IG, Koturbash I.
Environmental and molecular mutagenesis.Environ Mol Mutagen.2014 Jun;55(5):428-35. doi: 10.1002/em.21855. Epub 2014 Feb 17.
Respiratory mortality and morbidity has been associated with exposure to particulate matter (PM). Experimental evidence suggests involvement of cytotoxicity, oxidative stress, and inflammation in the development of PM-associated pathological states; however, the exact mechanisms remain unclear. In t
PMID 24535919

Japanese Journal

Thymic targets for Abelson murine leukemia virus are early γ/δT lymphocytes

HOLLAND G. D.
Proc. Natl Acad. Sci. USA 88, 3700, 1991
NAID 30016291055

B細胞分化における免疫グロブリン遺伝子の多様性獲得機構とその限定

白澤卓二
千葉医学雑誌 66(3), 183-191, 1990-06-01
… 本論文ではAbelsonマウス白血病ウイルス温度感受性株を用いて樹立した幼若B細胞クローンにin vitroで分化を誘導し,単一B前駆細胞由来の分化細胞群における免疫グロブリンH鎖遺伝子の多様性の獲得を検討した。 …
NAID 110006182653

リンパ球の分化と腫瘍化

竹森利忠
千葉医学雑誌 63(3), 149-151, 1987-06-01
NAID 110006180929

「エーベルソン・マウス白血病ウイルス」

Abelson murine leukemia virus
Virus classification
Group:	Group VI (ssRNA-RT)
Family:	Retroviridae
Subfamily:	Orthoretrovirinae
Genus:	Gammaretrovirus
Species:	Murine leukemia virus
Serotype
	Abelson murine leukemia virus