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1. 羊水量調節の生理学physiology of amniotic fluid volume regulation [show details]
…in the expression of AQPs in the placenta and fetal membranes. AQPs are a family of cell membrane water channels found ubiquitously in tissues. Multiple AQPs are currently known; AQP 1, 3, 8, 9, and 11 …
2. 肝性脳症：病因hepatic encephalopathy pathogenesis [show details]
…implicated is the water channel protein aquaporin-4 (AQP-4), which is abundantly expressed in astrocytes. Several observations support a potential role of AQP-4 in brain edema in in-vivo models of HE and in…
3. 赤血球水分量の制御control of red blood cell hydration [show details]
…across the red cell membrane by passive diffusion and also via a specific water channel aquaporin-1 (AQP-1), which is the prototype of the aquaporin family of transporters . Passive diffusion and water channels…

English Journal

Intravaginal treatment with Marantodes pumilum (Kacip Fatimah) ameliorates vaginal atrophy in rats with post-menopausal condition.

Tan NAS, Giribabu N, Karim K, Nyamathulla S, Salleh N.
Journal of ethnopharmacology. 2019 May;236()9-20.
Marantodes pumilum (MP) (Kacip Fatimah) is used to maintain the well-being of post-menopausal women. However, its role in ameliorating post menopause-related vaginal atrophy (VA) is unknown. To investigate the ability of intravaginal MP gel treatment to ameliorate VA in sex-steroid deficient conditi
PMID 30771519

Li S, Li C, Wang W.
American journal of physiology. Renal physiology. 2019 May;().
Emerging evidence has shown that bile acids play important roles in renal physiology and diseases by activating two major receptors, the nuclear farnesoid X receptor (FXR) and the membrane G protein-coupled bile acid receptor-1 (Gpbar1, also known as TGR5). Both FXR and TGR5 have been identified in
PMID 31091123

A versatile aquaporin-2 cell system for quantitative temporal expression and live-cell imaging.

Holst MR, Nejsum LN.
American journal of physiology. Renal physiology. 2019 May;().
AQP2 fine-tunes urine concentration in response to the antidiuretic hormone vasopressin. In addition, AQP2 has been suggested to promote cell migration and epithelial morphogenesis. A cell system allowing temporal and quantitative control of expression levels of AQP2 and phospho-mimicking mutants ha
PMID 31091121

Different Effects of Tolvaptan in Patients with Idiopathic Membranous Nephropathy with Nephrotic Syndrome

Tanaka Atsushi,Nakamura Tsukasa,Sato Eiichi,Ueda Yoshihiko,Node Koichi
Internal Medicine 56(2), 191-196, 2017
… Two distinct cases described herein illustrate the different effects of tolvaptan in responders and non-responders, according to the pre-treatment levels of AQP-2 immunostaining in the samples from renal biopsy and urinary levels of AQP-2 and osmolality, suggesting that these values may be useful predictors of response to tolvaptan in patients with nephrotic IMN. …
NAID 130005290564

黒崎雅之,中西裕之,泉並木
日本消化器病学会雑誌 114(1), 27-34, 2017
… ，有効循環血液量を減少させ腎障害を惹起するリスクがある．抗アルドステロン薬とループ利尿薬は基本となる薬剤であるが，作用機序の異なる水利尿薬が登場したことで治療選択肢が広がった．日本消化器病学会の肝硬変診療ガイドライン第2版では腹水の治療選択がフローチャート形式で示され，抗アルドステロン薬とループ利尿薬に対する不応例では水利尿薬の早期導入を検討することが推奨されている．</p> …
NAID 130005180904

柿木章伸
Equilibrium research 72(4), 274-279, 2013-08-01
… Experimentally, vasopressin type 2 receptor was expressed in the basal cell of the stria vascularis. … Moreover, the water channel of aquaporin (AQP) 2, the relocalization of which is regulated by vasopressin, was also expressed in the stria vascularis. …
NAID 10031194230

血管側の細胞膜に存在するV2受容体にAVPが結合すると、Gs蛋白、アデニル酸シクラーゼ、プロテインキナーゼAを介し、AQP2に作用する。細胞質内に存在するAQP2粒子は尿細管の管腔側細胞膜上へ移動し、それを通して水再吸収・尿濃縮作用が発現する。

バソプレッシンの作用で管腔側細胞膜にエキソサイトーシスされたAQP2 は、その一部が尿中に排泄される。健常者および中枢性尿崩症の患者では、バソプレッシンを投与することで尿中に排泄されるAQP2が増加するが、先天性腎性尿崩症の患者では、バソプレッシンを投与しても尿中に排泄されるAQP2 は増加しない。つまりバソプレッシンを投与して尿中のAQP2 排泄量の変化を調べることで、バソプレッシンが集合管に作用しているか否かを知ることができる。