5-HT1D receptor

• 5-HT1D受容体、5-HT1Dレセプター、セロトニン1D受容体、セロトニン1Dレセプター

関

5-HT1D serotonin receptor

WordNet

1. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

1. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/31 14:29:45」(JST)

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[Wiki en表示]

5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Identifiers
Symbols	HTR1D; 5-HT1D; HT1DA; HTR1DA; HTRL; RDC4
External IDs	OMIM: 182133 MGI: 96276 HomoloGene: 20240 IUPHAR: 5-HT1D ChEMBL: 1983 GeneCards: HTR1D Gene
Gene Ontology Molecular function • serotonin receptor activity • serotonin binding Cellular component • plasma membrane • integral to plasma membrane Biological process • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • synaptic transmission • response to toxin • intestine smooth muscle contraction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3352	15552
Ensembl	ENSG00000179546	ENSMUSG00000070687
UniProt	P28221	Q61224
RefSeq (mRNA)	NM_000864.4	NM_008309.4
RefSeq (protein)	NP_000855.1	NP_032335.2
Location (UCSC)	Chr 1: 23.52 – 23.52 Mb	Chr 4: 136.42 – 136.44 Mb
PubMed search	[1]	[2]

5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it. 5-HT_1D acts on the central nervous system, and affects locomotion and anxiety. It also induces vascular vasoconstriction in the brain.

Ligands

Agonists

• 5-(Nonyloxy)tryptamine,
• sumatriptan (vasoconstrictor in migraine)
• 5-Carboxamidotryptamine (5-CT)
• 5-(t-Butyl)-N-methyltryptamine
• CP-135,807
• CP-286,601
• PNU-109,291 ((S)-3,4-Dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-1H-2-benzopyran-6-carboxamide)
• PNU-142,633 ((1S)-1-[2-[4-[4-(Aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-1H-2-benzopyran-6-carboxamide)
• GR-46611 (3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide)
• L-694,247 (2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine)
• L-772,405

Antagonists

• Ziprasidone (atypical antipsychotic) [3]
• methiothepin (antipsychotic)
• yohimbine (aphrodisiac)
• metergoline
• ergotamine (vasoconstrictor in migraine)
• BRL-15572
• GR-127,935 (mixed 5-HT_1B/1D antagonist)
• LY-310,762
• LY-367,642
• LY-456,219
• LY-456,220

See also

• 5-HT₁ receptor
• 5-HT receptor

References

External links

• "5-HT_1D". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2314.

Further reading

• Hamblin MW, Metcalf MA, McGuffin RW, Karpells S (1992). "Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity.". Biochem. Biophys. Res. Commun. 184 (2): 752–9. doi:10.1016/0006-291X(92)90654-4. PMID 1315531.
• Weinshank RL, Zgombick JM, Macchi MJ, et al. (1992). "Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.". Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3630–4. doi:10.1073/pnas.89.8.3630. PMC 48922. PMID 1565658. //www.ncbi.nlm.nih.gov/pmc/articles/PMC48922/.
• Hamblin MW, Metcalf MA (1991). "Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.". Mol. Pharmacol. 40 (2): 143–8. PMID 1652050.
• Libert F, Passage E, Parmentier M, et al. (1992). "Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor.". Genomics 11 (1): 225–7. doi:10.1016/0888-7543(91)90125-X. PMID 1662665.
• Libert F, Parmentier M, Lefort A, et al. (1989). "Selective amplification and cloning of four new members of the G protein-coupled receptor family.". Science 244 (4904): 569–72. doi:10.1126/science.2541503. PMID 2541503.
• Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209.
• Salim K, Fenton T, Bacha J, et al. (2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation.". J. Biol. Chem. 277 (18): 15482–5. doi:10.1074/jbc.M201539200. PMID 11854302.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
• Bergen AW, van den Bree MB, Yeager M, et al. (2004). "Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa.". Mol. Psychiatry 8 (4): 397–406. doi:10.1038/sj.mp.4001318. PMID 12740597.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Li J, Zhang X, Wang Y, et al. (2007). "The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (8): 874–6. doi:10.1002/ajmg.b.30364. PMID 17099886.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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English Journal

• [Effects of fatigue and restraint stress on the expression of carnitine palmitoyltransferase-I and 5-hydroxytryptamine receptors in aorta of rats].

• Wei C, Han JK, Wang HT, Jia ZH, Chang LP, Wu YL.SourceDepartment of Integrative Chinese & Western Medicine, Hebei Medical University, Shijiazhuang, China.
• Zhonghua yi xue za zhi.Zhonghua Yi Xue Za Zhi.2011 Apr 5;91(13):915-9.
• OBJECTIVE: To investigate the effect of fatigue and restraint stress on the expressions of CPT (carnitine palmitoyltransferase)-I, PPAR (peroxisome proliferator-activated receptor) δ, 5-HT (hydroxytryptamine) 1D and 5-HT2A receptors in aorta of rats.METHODS: A total of 45 healthy male Wistar rats w
• PMID 21600121

• Applications of organocatalytic asymmetric synthesis to drug prototypes--dual action and selective inhibitors of n-nitric oxide synthase with activity against the 5-HT1D/1B subreceptors.

• Hanessian S, Stoffman E, Mi X, Renton P.SourceDepartment of Chemistry, Universite de Montreal, Montreal, QC, Canada. stephen.hanessian@umontreal.ca
• Organic letters.Org Lett.2011 Mar 4;13(5):840-3. Epub 2011 Jan 27.
• The scope of MacMillan's organocatalytic asymmetric conjugate addition reaction of indoles and electron-rich aromatics to α,β-unsaturated aldehydes has been extended to the use of 3-amino crotonaldehydes as substrates. The aromatics used include indoles as well as an aniline and a furan. The scope
• PMID 21271688

Japanese Journal

• Goshuyuto, a Traditional Japanese Medicine, and Aqueous Extracts of Evodiae Fructus Constrict Isolated Rat Aorta via Adrenergic and/or Serotonergic Receptors(Pharmacology)

• HIBINO Tomoko,YUZURIHARA Mitsutoshi,KANNO Hitomi,KASE Yoshio,TAKEDA Atsushi
• Biological & pharmaceutical bulletin 32(2), 237-241, 2009-02-01
• … Goshuyuto (1×10^<-5> … The vasoconstrictive effects of goshuyuto were significantly inhibited by pretreatment with prazosin, an adrenergic α_1 receptor antagonist. … The constrictive effects were partially inhibited by pretreatment with BRL15572, a 5-HT_<1D> … antagonist, and ketanserin, a 5-HT_<2A> … However, the constrictive effects were not inhibited by pretreatment with SB216641, a 5-HT_<1B> …
• NAID 110007042156

• 新規トリプタン, 安息香酸リザトリプタン(マクサルト^【○!R】)の片頭痛治療への導入

• 池本 文彦,融 太郎,相島 博,棗田 豊
• 日本薬理学雑誌 : FOLIA PHARMACOLOGICA JAPONICA 123(4), 295-302, 2004-04-01
• … 品名マクサルト）はセロトニン5-HT1B/1D受容体に対して強力かつ高い選択性を持つアゴニストである．今日の病態生理学によれば，片頭痛の発症には頭蓋内血管の拡張と三叉神経の活性化による種々の神経物質の遊離が主要な役割を果たしていると考えられている．硬膜血管では5-HT1B受容体は血管収縮に働き，三叉神経節では5-HT1D受容体は血管活動性神経ペプチ …
• NAID 10013514568

Related Links

• 5-HT1D receptor - NeuroLex - NeuroLex.org - The ...

Structured knowledge about 5-HT1D receptor, which is a Serotonin G-protein coupled receptor. Synonyms: 5 HT1D Receptor; 5 HT1DALPHA RECEPT; 5 Hydroxytryptamine1D Receptor; 5-HT1D Receptor; 5-HT1Dalpha Receptor; 5 ...

• 5-ht1d Receptor

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リンク元	「5-HT1D受容体」「5-HT1Dレセプター」「セロトニン1D受容体」「セロトニン1Dレセプター」
関連記事	「HT」

「5-HT1D受容体」

　　[★]

英

5-HT1D receptor

関

5-HT1Dレセプター、5-HT1Dセロトニンレセプター、セロトニン1Dレセプター、セロトニン1D受容体

「5-HT1Dレセプター」

　　[★]

英

5-HT1D receptor

関

5-HT1D受容体、セロトニン1Dレセプター、セロトニン1D受容体

「セロトニン1D受容体」

　　[★]

英

5-HT1D receptor

関

5-HT1D受容体、5-HT1Dレセプター、セロトニン1Dレセプター

「セロトニン1Dレセプター」

　　[★]

英

5-HT1D receptor

関

5-HT1D受容体、5-HT1Dレセプター、セロトニン1D受容体

「HT」

　　[★]

• 高血圧症 高血圧 hypertension
• 心移植 heart transplantation