11-hydroxyandrostenedione

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 急性前骨髄球性白血病の分子生物学 molecular biology of acute promyelocytic leukemia
2. 急性前骨髄球性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of acute promyelocytic leukemia in adults
3. 急性骨髄性白血病における細胞遺伝学 cytogenetics in acute myeloid leukemia
4. 急性リンパ芽球性白血病における細胞遺伝学 cytogenetics in acute lymphoblastic leukemia
5. 急性骨髄性白血病の分子遺伝学 molecular genetics of acute myeloid leukemia

Identification of new substrates for the CYP106A1-mediated 11-oxidation and investigation of the reaction mechanism.

Kiss FM1, Khatri Y1, Zapp J2, Bernhardt R3.
FEBS letters.FEBS Lett.2015 Aug 19;589(18):2320-6. doi: 10.1016/j.febslet.2015.07.011. Epub 2015 Jul 17.
CYP106A1 from Bacillus megaterium DSM319 was recently shown to catalyze steroid and terpene hydroxylations. Besides producing hydroxylated steroid metabolites at positions 6β, 7β, 9α and 15β, the enzyme displayed previously unknown 11-oxidase activity towards 11β-hydroxysteroids. Novel examples
PMID 26188546

11β-hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione.

Swart AC1, Schloms L, Storbeck KH, Bloem LM, Toit Td, Quanson JL, Rainey WE, Swart P.
The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2013 Nov;138:132-42. doi: 10.1016/j.jsbmb.2013.04.010. Epub 2013 May 16.
11β-Hydroxyandrostenedione (11OHA4), which is unique to the adrenal, was first isolated from human adrenal tissue in the fifties. It was later shown in the sixties that 11β-hydroxytestosterone (11OHT) was also produced by the human adrenal. Attention has shifted back to these adrenal androgens onc
PMID 23685396

11β-hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function.

Bloem LM1, Storbeck KH, Schloms L, Swart AC.
Molecules (Basel, Switzerland).Molecules.2013 Oct 25;18(11):13228-44. doi: 10.3390/molecules181113228.
The biological significance of 11β-hydroxyandrostenedione (11OHA4) has eluded researchers for the past six decades. It is now known that 11OHA4 is biosynthesized in the androgen arm of the adrenal steroidogenesis pathway and subsequently metabolized by steroidogenic enzymes in vitro, serving as pre
PMID 24165582