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Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer.

Ogasawara T, Itoh Y, Tamura M, Mushiroi T, Ukai Y, Kise M, Kimura K.SourceResearch Laboratories, Nippon Shinyaku Co., Ltd., Kyoto, Japan.
Pharmacology, biochemistry, and behavior.Pharmacol Biochem Behav.1999 Sep;64(1):41-52.
The effects of (+)-5-oxo-D-prolinepiperidinamide monohydrate (NS-105) on the scopolamine-, electrolytic lesion of the nucleus basalis magnocellularis (NBM)-, AF64A-, baclofen-, cerebral ischemia- and electroconvulsive shock (ECS)-induced memory disruption in the passive avoidance response or radial
PMID 10494996

Neurochemical and behavioral characterization of potential antidepressant properties of indeloxazine hydrochloride.

Yamaguchi T, Ohyama M, Suzuki M, Ozawa Y, Hatanaka K, Hidaka K, Yamamoto M.SourceDepartment of Pharmacology, Clinical Pharmacology Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan. yamagu_t@yamanouchi.co.jp
Neuropharmacology.Neuropharmacology.1998 Sep;37(9):1169-76.
The potential antidepressant properties of indeloxazine hydrochloride were examined in vitro and in vivo. Indeloxazine showed preferential affinity for both [3H] citalopram (Ki: 22.1 nM) and [3H]nisoxetine binding sites (Ki: 18.9 nM) in membranes of the rat cerebral cortex. In microdialysis studies,
PMID 9833647

Taste masking of bitter drug powder without loss of bioavailability by heat treatment of wax-coated microparticles.

Sugao H, Yamazaki S, Shiozawa H, Yano K.SourceNovel Pharma Laboratories Institute for Drug Development Research, Shizuoka, Japan. sugao@yamanouchi.co.jp
Journal of pharmaceutical sciences.J Pharm Sci.1998 Jan;87(1):96-100.
Indeloxazine hydrochloride (IDX), a cerebral activator, has a bitter astringent taste. To prepare powders of IDX without this bitter taste, microparticles (median diameter, 130 microns) of IDX were coated with a mixture comprising hydrogenated oil and surfactants in a fluidized bed using the side-sp
PMID 9452976