近交系NZBマウス、純系NZBマウス
- 関
- NZB mice、NZB mouse
WordNet
- produced by inbreeding
- the syllable naming the third (mediant) note of any major scale in solmization
- the 14th letter of the Roman alphabet (同)n
PrepTutorEJDIC
- 生まれつきの(inborn) / 近親交配による
- ミ(全音階の第3音)
- nitrogenの化学記号
- mouseの複数形
UpToDate Contents
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English Journal
- Leptin promotes lupus T-cell autoimmunity.
- Amarilyo G, Iikuni N, Shi FD, Liu A, Matarese G, La Cava A.Author information Department of Medicine, University of California at Los Angeles, CA, USA.AbstractIn systemic lupus erythematosus (SLE), the impairment in apoptosis can facilitate the initiation and maintenance of autoimmune responses to self antigens. Here we show that the adipocytokine leptin, which is abnormally elevated in SLE, promotes the survival and proliferation of autoreactive T-cells in mice with an autoreactive T-cell repertoire, including (NZB x NZW)F1 lupus-prone mice. This ability of leptin to promote lupus T-cell autoimmunity suggests the possibility of a therapeutic targeting of leptin in SLE.
- Clinical immunology (Orlando, Fla.).Clin Immunol.2013 Dec;149(3):530-3. doi: 10.1016/j.clim.2013.09.002. Epub 2013 Sep 12.
- In systemic lupus erythematosus (SLE), the impairment in apoptosis can facilitate the initiation and maintenance of autoimmune responses to self antigens. Here we show that the adipocytokine leptin, which is abnormally elevated in SLE, promotes the survival and proliferation of autoreactive T-cells
- PMID 24263282
- Mitochondrial gene polymorphisms that protect mice from colitis.
- Bär F, Bochmann W, Widok A, von Medem K, Pagel R, Hirose M, Yu X, Kalies K, König P, Böhm R, Herdegen T, Reinicke AT, Büning J, Lehnert H, Fellermann K, Ibrahim S, Sina C.Author information Medical Department I, University Hospital Schleswig-Holstein, Lübeck, Germany; Institute of Anatomy, University of Lübeck, Lübeck, Germany.AbstractBACKGROUND & AIMS: Dysregulated energy homeostasis in the intestinal mucosa frequently is observed in patients with ulcerative colitis (UC). Intestinal tissues from these patients have reduced activity of the mitochondrial oxidative phosphorylation (OXPHOS) complex, so mitochondrial dysfunction could contribute to the pathogenesis of UC. However, little is known about the mechanisms by which OXPHOS activity could be altered. We used conplastic mice, which have identical nuclear but different mitochondrial genomes, to investigate activities of the OXPHOS complex.
- Gastroenterology.Gastroenterology.2013 Nov;145(5):1055-1063.e3. doi: 10.1053/j.gastro.2013.07.015. Epub 2013 Jul 19.
- BACKGROUND & AIMS: Dysregulated energy homeostasis in the intestinal mucosa frequently is observed in patients with ulcerative colitis (UC). Intestinal tissues from these patients have reduced activity of the mitochondrial oxidative phosphorylation (OXPHOS) complex, so mitochondrial dysfunction
- PMID 23872498
- Hypertension in an experimental model of systemic lupus erythematosus occurs independently of the renal nerves.
- Mathis KW, Venegas-Pont M, Flynn ER, Williams JM, Maric-Bilkan C, Dwyer TM, Ryan MJ.Author information Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi; and.AbstractSystemic lupus erythematosus (SLE) is a chronic inflammatory disorder with prevalent hypertension and renal injury. In this study, we tested whether the renal nerves contribute to the development of hypertension in an established mouse model of SLE (NZBWF1). Female SLE and control (NZW/LacJ) mice were subjected to either bilateral renal denervation or a sham procedure at 32 wk of age. Two weeks later, blood pressure was assessed in conscious mice using carotid artery catheters. Blood pressure was higher in SLE mice compared with controls, as previously reported; however, blood pressure was not altered in the denervated SLE or control mice. The development of albuminuria was markedly blunted in denervated SLE mice; however, glomerulosclerosis was increased. Renal denervation reduced renal cortical expression of monocyte-chemoattractant protein in SLE mice but did not significantly alter renal monocyte/macrophage infiltration. Renal cortical TNF-α expression was also increased in sham SLE mice, but this was not impacted by denervation. This study suggests that the renal nerves do not have a significant role in the pathogenesis of hypertension, but have a complex effect on the associated renal inflammation and renal injury.
- American journal of physiology. Regulatory, integrative and comparative physiology.Am J Physiol Regul Integr Comp Physiol.2013 Oct 1;305(7):R711-9. doi: 10.1152/ajpregu.00602.2012. Epub 2013 Aug 7.
- Systemic lupus erythematosus (SLE) is a chronic inflammatory disorder with prevalent hypertension and renal injury. In this study, we tested whether the renal nerves contribute to the development of hypertension in an established mouse model of SLE (NZBWF1). Female SLE and control (NZW/LacJ) mice we
- PMID 23926131
Japanese Journal
- 古川 福実,吉益 隆,金澤 伸雄
- 日本臨床免疫学会会誌 = Japanese journal of clinical immunology 33(4), 169-173, 2010-08-31
- 自然発症性SLEモデルマウスは,皮膚の真皮表皮の境界部に免疫グロブリンあるいは補体が沈着する(Lupus band test LBT陽性).しかし,皮疹を自然発症するSLEモデルマウスは少ない.その中で,老齢MRL/nマウスの皮膚病変は,ヒトMCTD(混合性結合織病)の皮疹の所見に酷似し,MRL/lprマウスの皮膚病変はヒトLEに類似している.モデルマウスの研究から,各ストレインにはループス易 …
- NAID 10027753579
- 近交系マウス間における日本脳炎ウイルス末梢接種による感受性の差異
- 松尾 幸子,森田 公一,森田分藤 桂子,五十嵐 章
- ウイルス 44(2), 205-215, 1994
- … compared susceptibility of inbred mouse strains against intracerebral as well as peripheral challenge of a flavivirus, Japanese encephalitis (JE) virus, and the results were summarized as follows:(1) Seven inbred mouse strains (C3H/He, C57BL/6, BALB/c, AKR/N, NC, NZB, DBA/2) could be classified into following 3 groups by their mortality and infection rate when they were subcutaneously challenged with a wild JE virus strain isolated from field-caught mosquitoes at a single passage in mouse (B18AM, …
- NAID 130003854662
- 山本 順子 [他],山田 茂,藤巻 正人,内間 高夫
- 体力科學 42(4), 396-405, 1993-08-01
- … した.実験にはNZW/N, C3H/He, DBA, CBA/N, AKR/N, Balb/C, A/J, NZB/N, C57BLの9近交系を用いた.1週間のTail-up SuspensionによってS群の体重はC群に比べて有意に低くなった.C群の骨の大きさから比較すると骨が大きかった近交系は, NZB/N, AKR/N, NZW/N, C3H/Heであった.逆に骨が小さかった近交系はDBA, A/J, Balb/C, CBA/Nであった.脛骨絶対重量はNZW/N, C3H/He, Balb/C, NZB/N, C57BLA/Jの6近交系でS群の方がC群に比べて有意に …
- NAID 110001917685
Related Links
- Mice, Inbred NZB. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
- Species, Scientific Experts, Genomes and Genes, Research Grants, Publications, Research Topics about inbred nzb mice ... ..Taken together with our previous Ez studies, the present work calls into question the importance of class ...
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- 英
- inbred NZB mice
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- 純系NZBマウス、NZBマウス
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NZBマウス
- 関
- inbred NZB mice、NZB mouse
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- 英
- inbred NZB mice
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- 近交系NZBマウス
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- clone、inbred line、inbred strain、inbreed、inbreeding、pure line
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- mi-, mio-
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- MI
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NZBマウス
- 関
- inbred NZB mice、NZB mouse