immunotolerance

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1. 成人における肝移植：免疫抑制の概要 liver transplantation in adults overview of immunosuppression

Immune tolerance properties of the testicular tissue as a viral sanctuary site in ART-treated HIV-infected adults.

Jenabian MA1, Costiniuk CT, Mehraj V, Ghazawi FM, Fromentin R, Brousseau J, Brassard P, Bélanger M, Ancuta P, Bendayan R, Chomont N, Routy JP; Orchid study group.
AIDS (London, England).AIDS.2016 Nov 28;30(18):2777-2786.
OBJECTIVE: HIV persistence in long-lived infected cells and in anatomical sanctuary sites are major hurdles to HIV eradication. Testicular tissue may represent a significant viral sanctuary site as it constitutes an immunologically privileged compartment. We assessed immunotolerance properties of th
PMID 27677162

Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease.

Pfeifle R1,2, Rothe T1,2, Ipseiz N1,2, Scherer HU3, Culemann S1,2, Harre U1, Ackermann JA1,2, Seefried M2,4, Kleyer A1, Uderhardt S1,2, Haugg B1,2, Hueber AJ1, Daum P2,5, Heidkamp GF6, Ge C7, Böhm S4, Lux A4, Schuh W2,5, Magorivska I1, Nandakumar KS7, Lönnblom E7, Becker C8, Dudziak D6, Wuhrer M9, Rombouts Y3,9,10, Koeleman CA9, Toes R3, Winkler TH2,4, Holmdahl R7, Herrmann M1, Blüml S11, Nimmerjahn F4, Schett G1, Krönke G1,2.
Nature immunology.Nat Immunol.2016 Nov 7. doi: 10.1038/ni.3579. [Epub ahead of print]
The checkpoints and mechanisms that contribute to autoantibody-driven disease are as yet incompletely understood. Here we identified the axis of interleukin 23 (IL-23) and the TH17 subset of helper T cells as a decisive factor that controlled the intrinsic inflammatory activity of autoantibodies and
PMID 27820809

TGF-β affinity-bound to a macroporous alginate scaffold generates local and peripheral immunotolerant responses and improves allocell transplantation.

Orr S1, Strominger I2, Eremenko E2, Vinogradov E2, Ruvinov E1, Monsonego A3, Cohen S4.
Acta biomaterialia.Acta Biomater.2016 Nov;45:196-209. doi: 10.1016/j.actbio.2016.08.015. Epub 2016 Aug 11.
Enhancing vascularization of cell-transplantation devices is necessary for maintaining cell viability and integration within the host, but it also increases the risk of allograft rejection. Here, we investigated the feasibility of generating an immunoregulatory environment in a highly vascularized m
PMID 27523029

Development of New Composite Tissue Allotransplantation Models using supermicrosurgery:Medical Care (Immunology, Transplantation Therapy, Regenerative Medicine, Reconstructive Surgery, Health Care Economy* Welfere and Politics and Military

Yamamoto Takumi,Mihara Makoto,Narushirna Mitsunaga,Koshima Isao
Academic Collaborations for Sick Children 4(1), 16-20, 2011
Currently, the composite tissue allotransplantation (CTA) is used clinically. However, side effects due to the immunosuppressant agents not for critical grafting become a major issue. Immunological to …
NAID 130000941663