immunoreceptor tyrosine-based inhibitory motif

• 免疫受容抑制性チロシンモチーフ

関

ITIM

WordNet

1. any of various water-soluble compounds capable of turning litmus blue and reacting with an acid to form a salt and water; "bases include oxides and hydroxides of metals and ammonia" (同)alkali
2. (numeration system) the positive integer that is equivalent to one in the next higher counting place; "10 is the radix of the decimal system" (同)radix
3. the bottom side of a geometric figure from which the altitude can be constructed; "the base of the triangle"
4. situate as a center of operations; "we will base this project in the new lab"
5. a place that the runner must touch before scoring; "he scrambled to get back to the bag" (同)bag
6. installation from which a military force initiates operations; "the attack wiped out our forward bases" (同)base of operations
7. a support or foundation; "the base of the lamp" (同)pedestal, stand
8. (electronics) the part of a transistor that separates the emitter from the collector
9. a flat bottom on which something is intended to sit; "a tub should sit on its own base"
10. the principal ingredient of a mixture; "glycerinated gelatin is used as a base for many ointments"; "he told the painter that he wanted a yellow base with just a hint of green"; "everything she cooked seemed to have rice as the base"
11. the place where you are stationed and from which missions start and end (同)home
12. (anatomy) the part of an organ nearest its point of attachment; "the base of the skull"
13. the bottom or lowest part; "the base of the mountain"
14. illegitimate (同)baseborn
15. of low birth or station (`base is archaic in this sense); "baseborn wretches with dirty faces"; "of humble (or lowly) birth" (同)baseborn, humble, lowly
16. not adhering to ethical or moral principles; "base and unpatriotic motives"; "a base, degrading way of life"; "cheating is dishonorable"; "they considered colonialism immoral"; "unethical practices in handling public funds" (同)immoral
17. having or showing an ignoble lack of honor or morality; "that liberal obedience without which your army would be a base rabble"- Edmund Burke; "taking a mean advantage"; "chokd with ambition of the meaner sort"- Shakespeare; "something essentially vulgar and meanspirited in politics" (同)mean, meanspirited
18. (used of metals) consisting of or alloyed with inferior metal; "base coins of aluminum"; "a base metal"
19. debased; not genuine; "an attempt to eliminate the base coinage"
20. a design or figure that consists of recurring shapes or colors, as in architecture or decoration (同)motive
21. a theme that is repeated or elaborated in a piece of music (同)motive
22. a substance that retards or stops an activity
23. having a base; "firmly based ice"
24. having a base of operations (often used as a combining form); "a locally based business"; "an Atlanta-based company"; "carrier-based planes"
25. restrictive of action; "a repressive regime"; "an overly strict and inhibiting discipline" (同)repressive, repressing

PrepTutorEJDIC

1. 《文》(人や人の行動・孝えが)『卑しい』,下劣な / (金属が)質の劣った;(貨幣が)粗悪な
2. 『基礎』,根拠 / 『基部』,基底,土台 / 『根拠地』,基地 / (野球の)塁,ベース / 主成分;塩基(酸と反応シテ塩(官)を生じる化合物) / (数学で図形の)底;底辺;基線 / (…に)…‘の'『基礎をおく』《+『名』+『on』(『upon』)+『名』》
3. モチーフ / 文学・芸術作品の表現の中心となる主題 / 楽曲の主題 / デザインなどに繰り返して用いられる主模様
4. 抑制する人(物) / 化学反応抑制剤

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/30 20:54:16」(JST)

wiki en

[Wiki en表示]

An immunoreceptor tyrosine-based inhibition motif (ITIM), is a conserved sequence of amino acids (S/I/V/LxYxxI/V/L) that is found in the cytoplasmic tails of many inhibitory receptors of the immune system. After ITIM-possessing inhibitory receptors interact with their ligand, their ITIM motif becomes phosphorylated by enzymes of the Src kinase family, allowing them to recruit other enzymes such as the phosphotyrosine phosphatases SHP-1 and SHP-2, or the inositol-phosphatase called SHIP. These phosphatases decrease the activation of molecules involved in cell signaling. A list of human candidate ITIM-containing proteins has been generated by proteome-wide scans.

References

UpToDate Contents

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• 1. 肥満細胞：表面受容体とシグナル伝達 mast cells surface receptors and signal transduction
• 2. T細胞受容体シグナル伝達 t cell receptor signaling
• 3. 慢性骨髄性白血病の治療の概要 overview of the treatment of chronic myeloid leukemia
• 4. 免疫不全症を引き起こすCD3／T細胞受容体複合体疾患 cd3 t cell receptor complex disorders causing immunodeficiency
• 5. チロシン代謝障害 disorders of tyrosine metabolism

English Journal

• Testing the role of the FcγRIIB immunoreceptor tyrosine-based inhibitory motif in regulation of the B cell immune response.

• Vuyyuru R1, Shen S1, Manser T1.
• Immunity, inflammation and disease.Immun Inflamm Dis.2015 Sep;3(3):247-64. doi: 10.1002/iid3.64. Epub 2015 Jun 4.
• In vitro studies have demonstrated that the immunoreceptor tyrosine-based inhibitory motif (ITIM) of the inhibitory Fc receptor FcγRIIB is critical for mediating attenuation of signaling via immunoreceptor tyrosine-based activation motif (ITAM) containing receptors, such as the B cell antigen recep
• PMID 26417440

• Reversal of Arthritis by Human Monomeric IgA Through the Receptor-Mediated SH2 Domain-Containing Phosphatase 1 Inhibitory Pathway.

• Rossato E1, Ben Mkaddem S1, Kanamaru Y2, Hurtado-Nedelec M3, Hayem G4, Descatoire V5, Vonarburg C6, Miescher S6, Zuercher AW6, Monteiro RC1.
• Arthritis & rheumatology (Hoboken, N.J.).Arthritis Rheumatol.2015 Jul;67(7):1766-77. doi: 10.1002/art.39142.
• OBJECTIVE: Rheumatoid arthritis (RA), one of the most frequent chronic inflammatory rheumatic disorders, is characterized by the presence of autoantibodies and joint infiltration by activated immune cells, leading to cartilage and bone destruction. IgA occurs predominantly as monomers (mIgA) in plas
• PMID 25833812

• Inhibition of NKp30- and 2B4-mediated NK cell activation by evolutionary different human and bovine CEACAM1 receptors.

• Merkt W1,2, Urlaub D3, Meinke S1,4, Kammerer R5, Watzl C1,3.
• European journal of immunology.Eur J Immunol.2015 Jul;45(7):2134-42. doi: 10.1002/eji.201445151. Epub 2015 Apr 22.
• Carcinoembryonicantigen-related cell adhesion molecule 1 (CEACAM1) is a receptor involved in the regulation of NK-cell function. In most species, the CEACAM1 cytoplasmic tail possesses a membrane-proximal ITIM paired with a membrane-distal immunoreceptor tyrosine-based switch motif (ITSM) signaling
• PMID 25824372

Japanese Journal

• An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E–mediated immediate hypersensitivity reactions

• Hitomi Kaori,Tahara-Hanaoka Satoko,Someya Satoru,Fujiki Akira,Tada Hideaki,Sugiyama Tetsuya,Shibayama Shiro,Shibuya Kazuko,Shibuya Akira,田原 聡子,渋谷 和子,渋谷 彰
• Nature immunology 11(7), 601-607, 2010-07
• … Here we identify an immunoglobulin-like receptor, Allergin-1, that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM)-like domain, and show it was preferentially expressed on mast cells. … Mouse Allergin-1 recruited the tyrosine phosphatases SHP-1 and SHP-2 and the inositol phosphatase SHIP. …
• NAID 120002836956

• 樹状細胞に発現するCタイプレクチンdendritic cell immunoreceptor(DCIR)の機能と生体における働き (特集 自然免疫における活性化レセプターと阻止レセプター)

• 高原 和彦,布川 哲也,時枝 純佳
• 臨床免疫・アレルギー科 52(1), 11-18, 2009-07
• NAID 40016715329

• 抑制性レセプター,Siglec-8のヒト末梢血培養由来マスト細胞における発現とその機能 : アレルギー疾患に対する新しい創薬の可能性を秘めて(<特集>医学研究のUP-TO-DATE)

• 横井 秀格
• 順天堂医学 54(1), 2-9, 2008-03
• Siglec(sialic acid-binding Ig-like lectin)は,シアル酸含有糖鎖を認識するレクチン群であり細胞質内領域に抑制性シグナルモチーフITIMを持ち,そのチロシン残基のリン酸化が抑制性シグナル伝達の開始となる.これまでヒトには11種類(Siglec-1から11)が同定されており,主に血球系の細胞のsubsetに発現し,特に自然免疫システムに関与している.ヒトマスト細 …
• NAID 110007125196

Related Links

• Immunoreceptor tyrosine-based inhibitory motif (ITIM ...

1. Biochemistry. 2013 Apr 16;52(15):2597-608. doi: 10.1021/bi301461t. Epub 2013 Apr 3. Immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated inhibitory signaling is regulated by sequential phosphorylation mediated by ...

• Immunoreceptor tyrosine-based inhibition motifs: a quest in ...

1. Immunol Rev. 2008 Aug;224:11-43. doi: 10.1111/j.1600-065X.2008.00666.x. Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future. Daëron M(1), Jaeger S, Du Pasquier L, Vivier E. Author ...

Related Pictures

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★リンクテーブル★

リンク元	「ITIM」「免疫受容抑制性チロシンモチーフ」
拡張検索	「immunoreceptor tyrosine-based inhibitory motifs」
関連記事	「base」「inhibitor」「inhibitory」「immunoreceptor」

「ITIM」

　　[★] 免疫受容抑制性チロシンモチーフ

関

immunoreceptor tyrosine-based inhibitory motif, ITIM。immunoreceptor tyrosine-based activation motif, ITAM

特徴

• チロシンを持ち、共役するキナーゼによりリン酸化される。
• ....[I/V]XYXX[L/I]....

「免疫受容抑制性チロシンモチーフ」

　　[★]

英

immunoreceptor tyrosine-based inhibitory motif、ITIM

「immunoreceptor tyrosine-based inhibitory motifs」

　　[★]

同

ITIMs

同

ITIMs

「base」

　　[★]

• n.

• 基礎、基盤、根拠、基本、基底

関

basal、base、basement、basic、basis、element、elementary、evidence、foundation、fundamental、fundamentals、fundus、ground、infrastructure、reason

　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　

「inhibitor」

　　[★]

• n.

• 阻害剤、阻害薬、抑制薬、抑制剤、(内在性物質について)インヒビター、抑制物質

関

blocker、depressant、suppressant

　 　

「inhibitory」

　　[★]

• 抑制性の、抑制的な、阻害性の

関

inhibiting、suppressive

　

「immunoreceptor」

　　[★]

• 免疫受容体、免疫レセプター

関

immunologic receptor