免疫グロブリンアイソタイプ

WordNet

a class of proteins produced in lymph tissue in vertebrates and that function as antibodies in the immune response (同)Ig, immune serum globulin, immune gamma globulin, immune_globulin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/28 03:54:33」(JST)

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Some antibodies form complexes that bind to multiple antigen molecules.

An isotype refers to any related proteins from a particular gene family. In immunology, the "immunoglobulin isotype" refers to the phenotypic variations in the constant regions of the heavy and light chains. In humans, there are five heavy chain isotypes and two light chain isotypes:

heavy chain
- α - IgA 1, 2
- δ - IgD
- γ - IgG 1, 2, 3, 4
- ε - IgE
- μ - IgM
light chain
- κ
- λ

Immunoglobulin class switching can be used to change the class of the heavy chain, but not of the light chain.

Isotypes are distinct forms of light or heavy chains which are present in all members of a species, encoded at distinct genetic loci. Kappa and lambda are isotypes of light chains. Delta (δ), gamma:1 (γ1), etc. are isotypes of heavy chains. All isotypes can be readily found in normal sera.

External links

Immunoglobulin Isotypes at the US National Library of Medicine Medical Subject Headings (MeSH)
Overview at University of South Carolina School of Medicine
Overview at Southern Illinois University Carbondale

This immunology article is a stub. You can help Wikipedia by expanding it.

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1. 幼児期の一過性低ガンマグロブリン血症 transient hypogammaglobulinemia of infancy
2. 選択的IgA欠損症：臨床症状、病態生理、および診断 selective iga deficiency clinical manifestations pathophysiology and diagnosis
3. くすぶり型多発性骨髄腫 smoldering multiple myeloma
4. 胎児および新生児における免疫細胞の発達 the development of immune cells in the fetus and neonate
5. 軟骨毛髪形成不全症 cartilage hair hypoplasia

English Journal

Recent findings on the structure and function of teleost IgT.

Zhang YA, Salinas I, Oriol Sunyer J.SourceDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Fish & shellfish immunology.Fish Shellfish Immunol.2011 Nov;31(5):627-634. Epub 2011 Apr 3.
As key effector molecules of jawed vertebrate's adaptive immune system, immunoglobulins are produced by B lymphocytes, either as a secretory form (antibody) or as a membrane form (B cell receptor). Until recently, teleost fish B cells were thought to express only two classes of immunoglobulins, IgM
PMID 21466854

Sub-chronic effect of perfluorooctanesulfonate (PFOS) on the balance of type 1 and type 2 cytokine in adult C57BL6 mice.

Dong GH, Liu MM, Wang D, Zheng L, Liang ZF, Jin YH.SourceSchool of Public Health, China Medical University, North 2nd Road, 110001, Heping Districts, Shenyang, People's Republic of China, ghdong@mail.cmu.edu.cn.
Archives of toxicology.Arch Toxicol.2011 Oct;85(10):1235-44. Epub 2011 Feb 16.
As a ubiquitous and highly persistent environmental contaminant, the clear mechanisms to explain any perfluorooctanesulfonate (PFOS)-induced immunotoxicity are still unknown. This study here sought to examine the ability of PFOS to potentially perturb T-helper (T(H))-1 and T(H)-2 cell cytokine secre
PMID 21327619

Japanese Journal

喉頭癌発症におけるヒト乳頭腫ウイルス(HPV)の発現と喉頭局所免疫の関与

千年俊一,坂崎友,深堀光緒子,小野剛治,前田明輝,梅野博仁,中島格
喉頭 = The Larynx Japan 22(2), 83-87, 2010-12-01
… Cytological samples for the detection of HPV and laryngeal secretions for the collection of immunoglobulin (Ig) were obtained from 31 patients with laryngeal diseases during microscopic surgery of the larynx. … A comparison of laryngeal cancer and benign laryngeal diseases revealed that patients with laryngeal cancer had a higher concentration in each Ig isotype in laryngeal secretions than patients with benign laryngeal diseases. …
NAID 10027844398

Waldenstrom's macroglobulinemia in a 10-year stable IgG monoclonal gammopathy of undetermined significance

Iwanaga Masako,Yoshida Yoshiharu,Tagawa Masuko,Sekine Ichiro,Kamihira Shimeru,Tomonaga Masao
Leukemia Research 33(1), 193-195, 2009-01-01
NAID 120000916859