免疫グロブリンイディオタイプ

WordNet

a class of proteins produced in lymph tissue in vertebrates and that function as antibodies in the immune response (同)Ig, immune serum globulin, immune gamma globulin, immune_globulin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/19 15:40:43」(JST)

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The idiotype is based upon the variable region (labeled VL and VH in the diagram.)

In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T cell receptor (TCR) molecules based upon the antigen binding specificity and therefore structure of their variable region. The word idiotype comes from two Greek roots, idio meaning 'private, distinctive, peculiar' and typos meaning 'mark.' Thus idiotype describes the distinctive sequence and region that makes any immunoglobulin/TCR unique from others of the same type which is its variable region. The variable region of antigen receptors of T cells (TCRs) and B cells (immunoglobulins) contain complementarity determining regions (CDRs) with unique amino acid sequences. They define the surface and properties of the variable region, determining the antigen specificity and therefore the idiotope of the molecule. Immunoglobulins or TCRs with a shared idiotope are the same idiotype. Antibody idiotype is determined by

Gene rearrangement
Junctional diversity
P-nucleotides (palindromic nucleotides at sites of single-strand breaks)
N-nucleotides
Somatic hypermutations

The term idiotype is sometimes used to describe the collection of multiple idiotopes, and therefore overall antigen binding capacity, possessed by an antibody.

The word idiotype became influential in immunology when Niels Jerne formulated his immune network theory. Jerne was awarded the Nobel Prize for Medicine or Physiology in 1984 largely for being the father of immune network theory. He defined idiotype as the set of epitopes on the V region of an antibody molecule, where epitope means an antigenic determinant. He also defined the "paratope" to be that part of an antibody variable region that binds to an antigen. The best developed version of immune network theory is called the symmetrical network theory, in which the distinction between idiotype and paratope plays no role.

External links

Immunoglobulin idiotypes at the US National Library of Medicine Medical Subject Headings (MeSH)
Overview at Medical University of South Carolina
Overview at Southern Illinois University Carbondale

UpToDate Contents

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1. 免疫グロブリンの構造 structure of immunoglobulins

English Journal

BiovaxID®: a customized idiotype vaccine for the treatment of B-cell lymphoma.

Villanueva H, de Cerio AL, Inoges S, Pastor F, Soldevilla MM, Bendandi M.SourceLaboratory of Immunotherapy, Oncology Division, Center for Applied Medical Research, University of Navarra, Avda. Pio XII, 55-31008 Pamplona (Navarra), Spain.
Expert review of vaccines.Expert Rev Vaccines.2011 Dec;10(12):1661-9.
Most patients with B-cell lymphoma face an often incurable disease, particularly those diagnosed with an indolent subtype. The addition of passive immunotherapy to old and new chemotherapy regimens has improved both response rates and disease-free survival, leading in many cases to an extended overa
PMID 22085168

A competitive immunoassay with a surrogate calibrator curve for aflatoxin M1 in milk.

Guan D, Li P, Cui Y, Zhang Q, Zhang W.SourceOil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, China.
Analytica chimica acta.Anal Chim Acta.2011 Oct 3;703(1):64-9. Epub 2011 Jul 19.
A green enzyme-linked immunosorbent assay (ELISA) to measure aflatoxin M(1) (AFM(1)) in milk was developed and validated with a surrogate calibrator curve. Polyclonal anti-idiotype (anti-Id) antibody, used as an AFM(1) surrogate, was generated by immunizing rabbits with F(ab')(2) fragments from the
PMID 21843676

Japanese Journal

<b>イディオタイプ蛋白/尿酸ナトリウム結晶複合体ワクチンによる多発性骨髄腫に対する特異的免疫療法の検討（臨床第Ⅰ相試験）</b>

痛風と核酸代謝 39(1), 23-29, 2015
NAID 130005089282

Flow cytometric crossmatchおよび大量ヒト免疫グロブリン療法を用いた原因不明習慣流産管理

慶應醫學 73(2), T73-T88, 1996-03-25
NAID 10011380623

Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response