WordNet

a class of proteins produced in lymph tissue in vertebrates and that function as antibodies in the immune response (同)Ig, immune serum globulin, immune gamma globulin, immune_globulin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/06 22:13:38」(JST)

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The allotype affects the constant region (labeled CL and CH1-3 in the diagram.)

In immunology, an immunoglobulin allotype is the allele of the antibody chains found in the individual. The word allotype comes from two Greek roots, allo meaning 'other or differing from the norm' and typos meaning 'mark.' Thus allotype refers to the idea that each immunoglobin has unique sequences particular to the individual's genome that manifest in its constant region (normally).

The most important types are Gm (heavy chain) and km (light chain).

It can be used in resolving paternity disputes.^[1]

References

^ "THE STRUCTURE AND FUNCTION OF IMMUNOGLOBULINS - ANTIBODIES". Retrieved 2009-05-19.

External links

Immunoglobulin allotypes at the US National Library of Medicine Medical Subject Headings (MeSH)
allotype at eMedicine Dictionary
Overview at University of South Carolina School of Medicine
Overview at Southern Illinois University Carbondale

This immunology article is a stub. You can help Wikipedia by expanding it.

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1. 免疫グロブリンの構造 structure of immunoglobulins

English Journal

Inhibiting HLA-B27 homodimer-driven immune cell inflammation in spondyloarthritis.

Payeli SK, Kollnberger S, Osiris Marroquin B, Thiel M, McHugh K, Giles J, Shaw J, Kleber S, Ridley A, Wong-Baeza I, Keidel S, Kuroki K, Maenaka K, Wadle A, Renner C, Bowness P.SourceUniversity of Zurich, CH-8057, Zurich, Switzerland.
Arthritis and rheumatism.Arthritis Rheum.2012 May 10. doi: 10.1002/art.34538. [Epub ahead of print]
BACKGROUND.: Spondyloarthritides (SpA) including Ankylosing Spondylitis (AS) are common inflammatory rheumatic diseases dependent on possession of the HLA Class I allotype B27. HLA-B27 normally associates with beta 2-microglobulin (β2m) and peptide to form heterotrimers. However an unusual characte
PMID 22576154

From Genotypes of Immunoglobulin Constant Heavy G Chains (Fcγ) (GM) Genes (IGHG) to Phenotypes in Childhood Asthma.

Oxelius VA.SourceDepartment of Pediatrics and Institute of Laboratory Medicine, Department of Clinical Immunology, University Hospital, Lund University, Lund, Sweden.
International archives of allergy and immunology.Int Arch Allergy Immunol.2012 May 4;159(1):94-102. [Epub ahead of print]
Background: IgE-mediated allergy is associated with immunoglobulin heavy constant G chain (Fcγ) (GM) genes (IGHG) on chromosome 14q32.3. Investigation of the alternative GM allotypes of γ3, γ1 and γ2 chains has disclosed new structural and functional IgG subclasses and B-cell variants, with poss
PMID 22573066

Japanese Journal

The origin of the Japanese race based on genetic markers of immunoglobulin G

Matsumoto Hideo
Proceedings of the Japan Academy. Ser. B, Physical and Biological Sciences 85(2), 69-82, 2009-02
NAID 40016463182

Immunoglobulin G1 allotypes in intravenous immunoglobulin non-responders of kawasaki disease patients

Takegawa Tsuyoshi,Matsubara Tomoyo,Okuda Masayuki,Kaneko Miho,Ichiyama Takashi,Furukawa Susumu
The bulletin of the Yamaguchi Medical School 55(3-4), 27-33, 2008
… The standard therapy for Kawasaki disease (KD) consists of intravenous immunoglobulin (IVIG) treatment. … With regard to G1M(2), 8 of 14 (57.1％) IVIG non-responders, 19 of 69 (27.5％) IVIG responders, and 7 of 34 (20.6％) controls tested were positive for this allotype. … The G1M(2) was found to be significantly associated with the IVIG non-responders after adjustments for age, sex, and each allotype (odds ratio, 3.59; …
NAID 120001105652