immunoconjugate

• 免疫複合体

関

immune complex、immunocomplex

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/11 23:26:11」(JST)

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Immunoconjugates are antibodies conjugated (joined) to a second molecule, usually a toxin, radioisotope or label.

These conjugates are used in immunotherapy and to develop monoclonal antibody therapy as a targeted form of chemotherapy when they are often known as antibody-drug conjugates.

When the conjugates include a radioisotope see radioimmunotherapy. When the conjugates include a toxin see immunotoxin.

References

Further reading

• Technology Insight: cytotoxic drug immunoconjugates for cancer therapy. 2007 looks useful from the abstract.
• Targeted Therapy of Cancer: New Prospects for Antibodies and Immunoconjugates. 2006 full article, 18 pages.
• Arming antibodies: prospects and challenges for immunoconjugates. 2005 10 pages.

UpToDate Contents

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• 1. 有毛細胞白血病の治療 treatment of hairy cell leukemia

English Journal

• Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma: current and future perspectives in adult and paediatric disease.

• Eyre TA1, Khan D, Hall GW, Collins GP.
• European journal of haematology.Eur J Haematol.2014 Dec;93(6):455-68. doi: 10.1111/ejh.12360. Epub 2014 May 21.
• Anaplastic large cell lymphoma (ALCL) is a rare T-cell lymphoma seen in both adults and children. ALCL is associated with a characteristic chromosomal translocation, t(2;5)(p23;35) which fuses the anaplastic lymphoma kinase (ALK) gene on chromosome 2 with the nucleophosmin (NPM) gene on chromosome 5
• PMID 24766435

• Chemoenzymatic Strategy for the Synthesis of Site-Specifically Labeled Immunoconjugates for Multimodal PET and Optical Imaging.

• Zeglis BM1, Davis CB, Abdel-Atti D, Carlin SD, Chen A, Aggeler R, Agnew BJ, Lewis JS.
• Bioconjugate chemistry.Bioconjug Chem.2014 Nov 26. [Epub ahead of print]
• The complementary nature of positron emission tomography (PET) and optical imaging (OI) has fueled increasing interest in the development of multimodal PET/OI probes that can be employed during the diagnosis, staging, and surgical treatment of cancer. Due to their high selectivity and affinity, anti
• PMID 25418333

• Current status of antibody therapy in ALL.

• Ai J1, Advani A.
• British journal of haematology.Br J Haematol.2014 Nov 10. doi: 10.1111/bjh.13205. [Epub ahead of print]
• Despite the significant advances in modern chemotherapy, it remains challenging to treat adult patients with acute lymphoblastic leukaemia (ALL). The relapse rate remains high, and the outcome at the time of relapse is dismal. Antibody-based therapies have demonstrated promising results in this pati
• PMID 25382151

Japanese Journal

• 抗体療法の基礎(種類,特徴など) : 概論 (特集 固形がんの免疫・抗体療法 : 基礎研究の進歩と臨床応用) -- (基礎研究の進歩と展望 : 抗体療法)

• 谷口 博昭,今井 浩三
• 日本臨床 70(12), 2087-2092, 2012-12
• NAID 40019493239

• ナノDDSによる腫瘍治療 : 臨床治験の現状 (特集 疾患治療とドラッグデリバリーシステム)

• 松村 保広
• 細胞 44(2), 60-63, 2012-02
• NAID 40019336103

• New concept of cytotoxic immunoconjugate therapy targeting cancer-induced fibrin clots

• YASUNAGA Masahiro,MANABE Shino,MATSUMURA Yasuhiro
• Cancer science 102(7), 1396-1402, 2011-07-10
• NAID 10029295613

Related Links

• Immunoconjugate - Wikipedia, the free encyclopedia

Immunoconjugates are antibodies conjugated (joined) to a second molecule, usually a toxin, radioisotope or label. These conjugates are used in immunotherapy and to develop monoclonal antibody therapy as a targeted form of ...

• Immunoconjugate - Medical Dictionary - The Free Dictionary

monoclonal antibodies which are target-specific carriers for specific compounds such as plant or bacterial toxins, radionuclides, photoactive agents and chemotherapeutic drugs. Want to thank TFD for its existence? Tell a friend about us, add a ...

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• 免疫複合体

関

immune complex、immunoconjugate