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Immune complex diseases

An immune complex is formed from the integral binding of an antibody to a soluble antigen.^[1] The bound antigen and antibody act as a specific epitope, and is referred to as a singular immune complex. After an antigen-antibody reaction, the immune complexes can be subject to any of a number of responses, including complement deposition, opsonization,^[2] phagocytosis, or processing by proteases. Red blood cells carrying CR1-receptors on their surface may bind C3b-coated immune complexes and transport them to phagocytes, mostly in liver and spleen, and return to the general circulation.

Immune complexes may themselves cause disease when they are deposited in organs, e.g. in certain forms of vasculitis. This is the third form of hypersensitivity in the Gell-Coombs classification, called type III hypersensitivity.^[3]

Immune complex deposition is a prominent feature of several autoimmune diseases, including systemic lupus erythematosus, cryoglobulinemia, rheumatoid arthritis, scleroderma and Sjögren's syndrome.^[4]^[5]

References

^ Cush, John; Kavanaugh, Arthur; Stein, Charles (2005). Rheumatology: Diagnosis and Therapeutics. Lippincott Williams & Wilkins. p. 78. ISBN 9780781757324. |access-date= requires |url= (help)
^ Goldsby, Richard (2002). Immunology. Macmillan. p. 381. ISBN 9780716749479.
^ Barret, James (1980). Basic Immunology and its Medical Application (2 ed.). St.Louis: The C.V. Mosby Company. ISBN 0-8016-0495-8.
^ Lawley, Thomas; Moustopoulos, Haralampos (1979). "Demonstration of Circulating Immune Complexes in Sjögren's Syndrome". Journal of Immunology (The American Association of Immunologists) 123 (3): 1382–7. PMID 469255.
^ Wallace, Daniel, ed. (2004). The New Sjogren's Syndrome Handbook. Oxford University Press. p. 68. ISBN 9780198038481. |access-date= requires |url= (help)

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English Journal

Dose-response curve of a microfluidic magnetic bead-based surface coverage sandwich assay.

Cornaglia M1, Trouillon R1, Tekin HC1, Lehnert T1, Gijs MA2.
New biotechnology.N Biotechnol.2015 Sep 25;32(5):433-40. doi: 10.1016/j.nbt.2015.03.008. Epub 2015 Mar 24.
Magnetic micro- and nanoparticles ('magnetic beads') have been used to advantage in many microfluidic devices for sensitive antigen (Ag) detection. Today, assays that use as read-out of the signal the number count of immobilized beads on a surface for quantification of a sample's analyte concentrati
PMID 25817550

O-GlcNAcylation of the human epidermal growth factor receptor.

Stateva SR1, Villalobo A.
Organic & biomolecular chemistry.Org Biomol Chem.2015 Jun 25. [Epub ahead of print]
The reversible O-linked attachment of single β-d-N-acetylglucosamine (GlcNAc) moieties to serine/threonine residues in target proteins is a frequently occurring post-translational modification affecting the functionality of many cellular systems. In this report we present experimental evidence sugg
PMID 26108188

A new colorimetric platform for ultrasensitive detection of protein and cancer cells based on the assembly of nucleic acids and proteins.

Chen C1, Liu Y1, Zheng Z2, Zhou G1, Ji X1, Wang H2, He Z3.
Analytica chimica acta.Anal Chim Acta.2015 Jun 23;880:1-7. doi: 10.1016/j.aca.2015.05.010. Epub 2015 May 11.
An amplified colorimetric method has been developed for the detection of protein and cancer cells based on the assembly of nucleic acids and proteins for the first time. In this process, the assembly of nucleic acids was triggered by a biotinylated DNA strand after a sandwich immunoreaction. The bio
PMID 26092332

Japanese Journal

自己免疫性溶血性貧血を合併した間質性肺炎の1例

玉置健一郎,鍋谷大二郎,辻泰佑,青山眞弓,久保嘉朗
日本呼吸器学会雑誌 = The journal of the Japanese Respiratory Society 48(6), 426-431, 2010-06-10
NAID 10027677100

Peripheral Neuropathy in Japanese Patients with Hepatitis C Virus Infection

IJICHI Toshiharu,KONO Ichiyo,MORI Satoru,NAKAJIMA Kenji,NAKAGAWA Masanori,OKANOUE Takeshi
Internal medicine 42(5), 394-399, 2003-05-01
Objective The aim of this study was to report a series of Japanese patients with neuropathic symptoms following HCV infection. Patients and Methods Fifteen patients with neuropathic symptoms and HCV i …
NAID 10010739296