WordNet

any compound of oxygen with another element or a radical
a tricyclic antidepressant (trade names Imavate and Tofranil) used to treat clinical depression (同)impramine hydrochloride, Imavate, Tofranil

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酸化物

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/14 05:40:25」(JST)

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Imipraminoxide (Imiprex, Elepsin), or imipramine N-oxide, is a tricyclic antidepressant (TCA) that was introduced in Europe in the 1960s for the treatment of depression.^[1]^[2]^[3]^[4]

Imipraminoxide is both an analogue and a metabolite of imipramine, and has similar effects.^[5]^[6]^[7]^[8] However, in clinical trials, imipraminoxide was found to have a faster onset of action, slightly higher efficacy, and fewer and less marked side effects, including diminished orthostatic hypotension and anticholinergic effects like dry mouth, sweating, dizziness, and fatigue.^[5]^[6]^[7]^[8]^[9]^[10]

Imipraminoxide's pharmacology has not been well elucidated, but based on its very close relationship with imipramine, it likely acts as a serotonin and norepinephrine reuptake inhibitor and serotonin, adrenenaline, histamine, and muscarinic acetylcholine receptor antagonist, though with weaker antiadrenergic and anticholinergic actions.^[9]^[10]

References

^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 546. ISBN 3-88763-075-0.
^ Dictionary of organic compounds. London: Chapman & Hall. 1996. p. 3877. ISBN 0-412-54090-8.
^ FAURBYE A, JACOBSEN O, KRISTJANSEN P, MUNKVAD I (September 1963). "Imipramine-N-oxide: preliminary investigation of a new antidepressive drug". The American Journal of Psychiatry. 120: 277–8. PMID 13944543.
^ Lingjaerde O (November 1971). "[Imiprex "Dumex" (imipramine oxide). A new tricyclic antidepressive agent]". Tidsskrift for Den Norske Lægeforening : Tidsskrift for Praktisk Medicin, Ny Række (in Norwegian). 91 (31): 2267–8. PMID 5133241.
^ ^a ^b Rapp W, Norén MB, Pedersen F (1973). "Comparative trial of imipramine N-oxide and imipramine in the treatment of out-patients with depressive syndromes". Acta Psychiatrica Scandinavica. 49 (1): 77–90. doi:10.1111/j.1600-0447.1973.tb04400.x. PMID 4572170.
^ ^a ^b Aronson, Jeffrey Kenneth (2008). Meyler's Side Effects of Psychiatric Drugs (Meylers Side Effects). Amsterdam: Elsevier Science. p. 34. ISBN 0-444-53266-8.
^ ^a ^b Dencker SJ (1971). "[Clinical trial with imipramine-N-oxide and amitriptyline-N-oxide]". Nordisk Psykiatrisk Tidsskrift. Nordic Journal of Psychiatry (in Swedish). 25 (5): 463–70. PMID 4947298.
^ ^a ^b Beale, John Marlowe; Wilson, Charles Henry; Gisvold, Ole; Block, John H. (2004). Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry. Hagerstwon, MD: Lippincott Williams & Wilkins. p. 87. ISBN 0-7817-3481-9.
^ ^a ^b Dencker SJ, Bake B (July 1976). "Investigation of the orthostatic reaction after intravenous administration of imipramine, chlorimipramine, and inimpramine-N-oxide". Acta Psychiatrica Scandinavica. 54 (1): 74–8. doi:10.1111/j.1600-0447.1976.tb00095.x. PMID 952235.
^ ^a ^b Clemmesen L, Mikkelsen PL, Lund H, Bolwig TG, Rafaelsen OJ (1984). "Assessment of the anticholinergic effects of antidepressants in a single-dose cross-over study of salivation and plasma levels". Psychopharmacology. 82 (4): 348–54. doi:10.1007/BF00427684. PMID 6427827.

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Japanese Journal

Effects of intraperitoneally injected lithium, imipramine and diazepam on nitrate levels in rat amygdala

MARUTA SHUJI,SUZUKI EIJI,YOKOYAMA MASAMOTO,SATO TAKU,INADA KEN,WATANABE SHIGERU,MIYAOKA HITOSHI
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NAID 10018029006

Extremely High Drug-Reductase Activity Based on Aldehyde Oxidase in Monkey Liver

KITAMURA Shigeyuki,NAKATANI Keiko,OHASHI Koji,SUGIHARA Kazumi,HOSOKAWA Ryuji,AKAGAWA Yasumasa,OHTA Shigeru
Biological & pharmaceutical bulletin 24(7), 856-859, 2001-07-01
… Monkey liver cytosol exhibited significant reductase activities toward zonisamide, sulindac and imipramine N-oxide in the presence of 2-hydroxy-pyrimidine or benzaldehyde, an electron donor to aldehyde oxidase. … It appears that the high levels of aldehyde oxidase exists in monkey liver, and zonisamide, sulindac and imipramine N-oxide are mainly reduced by this enzyme, not by cytochrome P450. …
NAID 110003638575

「oxide」

Imipraminoxide
Clinical data
Routes of; administration	oral
ATC code	N06AA03 (WHO);
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 3-(5,6-dihydrobenzo[b][f]benzazepin- 11-yl)- N,N-dimethyl- propan- 1-amine N-oxide;
CAS Number	6829-98-7;
PubChem CID	65589;
ChemSpider	59031;
UNII	8MKS280XJW;
KEGG	D07334;
ChEMBL	CHEMBL1614644;
ECHA InfoCard	100.027.188
Chemical and physical data
Formula	C19H24N2O
Molar mass	296.41 g/mol

　　[★]

酸化物、オキシド、オキサイド　　

「imipramine」

　　[★] イミプラミン

同: Tofranil

[isbn3-88763-075-0-1] Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 546. ISBN 3-88763-075-0.

[isbn0-412-54090-8-2] Dictionary of organic compounds. London: Chapman & Hall. 1996. p. 3877. ISBN 0-412-54090-8.

[pmid13944543-3] FAURBYE A, JACOBSEN O, KRISTJANSEN P, MUNKVAD I (September 1963). "Imipramine-N-oxide: preliminary investigation of a new antidepressive drug". The American Journal of Psychiatry. 120: 277–8. PMID 13944543.

[pmid5133241-4] Lingjaerde O (November 1971). "[Imiprex "Dumex" (imipramine oxide). A new tricyclic antidepressive agent]". Tidsskrift for Den Norske Lægeforening : Tidsskrift for Praktisk Medicin, Ny Række (in Norwegian). 91 (31): 2267–8. PMID 5133241.

[pmid4572170-5] Rapp W, Norén MB, Pedersen F (1973). "Comparative trial of imipramine N-oxide and imipramine in the treatment of out-patients with depressive syndromes". Acta Psychiatrica Scandinavica. 49 (1): 77–90. doi:10.1111/j.1600-0447.1973.tb04400.x. PMID 4572170.

[isbn0-444-53266-8-6] Aronson, Jeffrey Kenneth (2008). Meyler's Side Effects of Psychiatric Drugs (Meylers Side Effects). Amsterdam: Elsevier Science. p. 34. ISBN 0-444-53266-8.

[pmid4947298-7] Dencker SJ (1971). "[Clinical trial with imipramine-N-oxide and amitriptyline-N-oxide]". Nordisk Psykiatrisk Tidsskrift. Nordic Journal of Psychiatry (in Swedish). 25 (5): 463–70. PMID 4947298.

[isbn0-7817-3481-9-8] Beale, John Marlowe; Wilson, Charles Henry; Gisvold, Ole; Block, John H. (2004). Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry. Hagerstwon, MD: Lippincott Williams & Wilkins. p. 87. ISBN 0-7817-3481-9.

[pmid952235-9] Dencker SJ, Bake B (July 1976). "Investigation of the orthostatic reaction after intravenous administration of imipramine, chlorimipramine, and inimpramine-N-oxide". Acta Psychiatrica Scandinavica. 54 (1): 74–8. doi:10.1111/j.1600-0447.1976.tb00095.x. PMID 952235.

[pmid6427827-10] Clemmesen L, Mikkelsen PL, Lund H, Bolwig TG, Rafaelsen OJ (1984). "Assessment of the anticholinergic effects of antidepressants in a single-dose cross-over study of salivation and plasma levels". Psychopharmacology. 82 (4): 348–54. doi:10.1007/BF00427684. PMID 6427827.

v t e Tricyclics

Classes	Acridine Anthracene Dibenzazepine Dibenzocycloheptene Dibenzodiazepine Dibenzothiazepine Dibenzothiepin Dibenzoxazepine Dibenzoxepin Phenothiazine Pyridazinobenzoxazine Pyridinobenzodiazepine Thioxanthene

Antidepressants (TCAs and TeCAs)	7-OH-Amoxapine Amezepine Amineptine Amitriptyline Amitriptylinoxide Amoxapine Aptazapine Azepindole Azipramine Batelapine Butriptyline Cianopramine Ciclazindol Ciclopramine Cidoxepin Clomipramine Cotriptyline Cyanodothiepin Demexiptiline Depramine/Balipramine Desipramine Dibenzepin Dimetacrine Dosulepin/Dothiepin Doxepin Enprazepine Esmirtazapine Fantridone Fluotracen Hepzidine Homopipramol Imipramine Imipraminoxide Intriptyline Iprindole Ketipramine Litracen Lofepramine Losindole Loxapine Maprotiline Mariptiline Mazindol Melitracen Metapramine Mezepine Mianserin Mirtazapine Monometacrine Naranol Nitroxazepine Nortriptyline Noxiptiline Octriptyline Opipramol Oxaprotiline Pipofezine Pirandamine Propizepine Protriptyline Quinupramine Setiptiline/Teciptiline Spiroxepin Tandamine Tampramine Tianeptine Tienopramine Trimipramine

Antihistamines	Azatadine Clobenzepam Cyproheptadine Dacemazine Deptropine Desloratadine Epinastine Etymemazine Fenethazine Hydroxyethylpromethazine Isopromethazine Isothipendyl Ketotifen Latrepirdine Loratadine Mebhydrolin Mequitazine Methdilazine Olopatadine Oxomemazine Phenindamine Pimethixene Promethazine Propiomazine Rupatadine Thiazinamium

Antipsychotics	Acetophenazine Alimemazine Amoxapine Asenapine Butaclamol Butaperazine Carfenazine (carphenazine) Carpipramine Chlorpromazine Chlorprothixene Ciclindole Citatepine Clocapramine Clomacran Clorotepine Clotiapine Clozapine Cyanothepin Doclothepin Docloxythepin Erizepine Flucindole Flumezapine Fluotracen Flupentixol Fluphenazine Gevotroline Homopipramol Isofloxythepin Levomepromazine/Methotrimeprazine Loxapine Maroxepin Meperathiepin Mesoridazine Metiapine Metitepine Metoxepin Mosapramine Naranol Octomethothepin Olanzapine Oxyclothepin Oxyprothepin Pentiapine Peradithiepin Perathiepin Perazine Perphenazine Periciazine Pinoxepin Piperacetazine Pipotiazine Piquindone Prochlorperazine Promazine Prothipendyl Quetiapine Savoxepin/Cipazoxapine Sulforidazine Tenilapine Thiethylperazine Thiopropazate Thioridazine Thiothixene Tilozepine Traboxopine Trifluoperazine Triflupromazine Trifluthepin Zotepine Zuclopenthixol

Anticonvulsants	Carbamazepine Dizocilpine Eslicarbazepine Eslicarbazepine acetate Etazepine Licarbazepine Oxcarbazepine Oxitriptyline Rispenzepine

Others	Adosopine Aminopromazine Atiprosin Beloxepin Carvedilol Cidoxepin Cyclobenzaprine Damotepine Darenzepine Elanzepine Methylene blue Monatepil Nuvenzepine Oxetorone Perlapine P7C3 Pinadoline Pirenzepine Pirolate Pitrazepin Pizotifen Profenamine Serazapine Siltenzepine Telenzepine Tipindole Tropatepine Zolenzepine

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imipramine oxide