imidocarb

Imidocarb
Names
	IUPAC name 1,3-Bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea
	Other names Imizocarb; Imizol; Diamidine
Identifiers
CAS Number	27885-92-3
ChemSpider	20102
Jmol 3D model	Interactive image
PubChem	21389
UNII	8USS3K0VDH
	InChI InChI=1S/C19H20N6O/c26-19(24-15-5-1-3-13(11-15)17-20-7-8-21-17)25-16-6-2-4-14(12-16)18-22-9-10-23-18/h1-6,11-12H,7-10H2,(H,20,21)(H,22,23)(H2,24,25,26) Key: SCEVFJUWLLRELN-UHFFFAOYSA-N ; InChI=1/C19H20N6O/c26-19(24-15-5-1-3-13(11-15)17-20-7-8-21-17)25-16-6-2-4-14(12-16)18-22-9-10-23-18/h1-6,11-12H,7-10H2,(H,20,21)(H,22,23)(H2,24,25,26) Key: SCEVFJUWLLRELN-UHFFFAOYAD ;
	SMILES O=C(Nc2cc(C/1=N/CCN\1)ccc2)Nc3cccc(c3)/C4=N/CCN4 ;
Properties
Chemical formula	C19H20N6O
Molar mass	348.41 g·mol−1
Pharmacology
ATCvet code	QP51AE01 (WHO)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

イミドカルブ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/30 13:25:05」(JST)

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1. バベシア症の臨床症状、診断、治療、および予防 clinical manifestations diagnosis treatment and prevention of babesiosis

English Journal

Tick-borne Diseases (Borreliosis, Anaplasmosis, Babesiosis) in German and Austrian Dogs: Status quo and Review of Distribution, Transmission, Clinical Findings, Diagnostics and Prophylaxis.

Pantchev N1, Pluta S, Huisinga E, Nather S, Scheufelen M, Vrhovec MG, Schweinitz A, Hampel H, Straubinger RK.
Parasitology research.Parasitol Res.2015 Jul 9. [Epub ahead of print]
Tick-borne diseases (TBD) in dogs have gained in significance in German and Austrian veterinary practices. The widespread European tick species Ixodes ricinus represents an important vector for spirochaetes of the Borrelia burgdorferi sensu lato group and Rickettsiales such as Anaplasma phagocytophi
PMID 26152408

Clinical babesiosis and molecular identification of Babesia canis and Babesia gibsoni infections in dogs from Serbia.

Davitkov D1, Vucicevic M, Stevanovic J, Krstic V, Tomanovic S, Glavinic U, Stanimirovic Z.
Acta veterinaria Hungarica.Acta Vet Hung.2015 Jun;63(2):199-208. doi: 10.1556/AVet.2015.017.
Canine babesiosis is a frequent and clinically significant tick-borne disease. Sixty symptomatic dogs with clinical findings compatible with babesiosis were included in this study conducted in Serbia. After clinical examination, blood samples were taken for microscopic examination, complete blood co
PMID 26051258

Theileria equi isolates vary in susceptibility to imidocarb dipropionate but demonstrate uniform in vitro susceptibility to a bumped kinase inhibitor.

Hines SA1, Ramsay JD2, Kappmeyer LS3,4, Lau AO5, Ojo KK6, Van Voorhis WC7, Knowles DP8,9, Mealey RH10.
Parasites & vectors.Parasit Vectors.2015 Jan 20;8:33. doi: 10.1186/s13071-014-0611-6.
BACKGROUND: The apicomplexan hemoparasite Theileria equi is a causative agent of equine piroplasmosis, eradicated from the United States in 1988. However, recent outbreaks have sparked renewed interest in treatment options for infected horses. Imidocarb dipropionate is the current drug of choice, ho
PMID 25600252

Japanese Journal

LC-MS/MSを用いた畜水産食品中のイミドカルブの分析

石井里枝,高橋邦彦,松本隆二
食品衛生学雑誌 52(1), 34-39, 2011
高速液体クロマ卜グラフ－タンデム質量分析計（LC-MS／MS）を用いた10種の畜水産食品中の抗原虫剤イミドカルブの簡便な分析法を検討した。カラムにTSK VMpak-25を、移動相に酢酸アンモニウム－アセトニトリルを用い、ESI、ポジティブモードで測定した。分析に供する試験溶液は、試料を塩基性条件下、アセトニトリルで抽出し、調製した。はちみつ以外の試料には脂質などの除去 …
NAID 130000671809

Imidocarb, Artesunate, Arteether, Buparvaquone, ArteetherとBuparvaquone混合物のBabesia equi実験感染ロバに対する治療効果(寄生虫病学)

Kumar Sanjay,Gupta Ashok K.,Pal Yash [他],DWIVEDI Shailendra K.
The journal of veterinary medical science 65(11), 1171-1177, 2003-11-25
… るImidocarb,Artesunate,Arteether,Buparvaquone,Arteether+ Buparvaquone混合物をロバ(1群3頭)に投与し,治療効果をパラシテミア,血液性状(WBC,RBC,PCV,granulocytes,haemoglobin),生化学的データ(SCOT,SGPT,alkaline phosphatase,albumin/globulin ratio)を定期的に測定して検討した.ArteetherとBuparvaquoneは効果が見られず,投薬後数日以内にロバは高パラシテミアと臨床症状を示して死亡した.Arteether投与群は投薬期間のみ原虫の増殖を抑制した.Imidocarbと …
NAID 110003920977

ナフトキノーン製剤及びイミドカルブの抗タイレリア効果

南哲郎 [他],中野光志,清水真也,志村亀夫,藤永徹,伊藤進午
日本獣医学雑誌 47(2), 297-300, 1985-04-00
Theileria sergenti感染摘脾子牛を用いて, ナフトキノーン製剤(パルバコン, 720C)及びイミドカルブの抗タイレリア効果を調べた. パルバコン及び720Cは赤血球内型原虫に対して即効性を示したが, イミドカルブは遅効性で, 6mg/kg以上の応用では副作用を示した. 720Cについて寄生率が5.3〜23.2%に達した時に2.5〜10mg/kgを筋肉内に1回注射したところ, 赤血球 …
NAID 110003916774

Related Pictures

Venta de Imidocarb en Guadalajara, Jalisco, Mexico Imidocarb Dipropionate | Active Pharmaceutical Ingredient Imidocarb - Cat Imidocarb - LH - LIVISTO IMIDOCARB 120 INJ. – Kepro

[1] Hashemi-Fesharki, R (1977). "Studies on imidocarb dihydrochloride in experimental Babesia ovis infection in splenectomized lambs". The British veterinary journal. 133 (6): 609–14. PMID 608109.

[2] Hashemi-Fesharki, R (1975). "Studies on imidocarb dihydrochloride in experimental Babesia bigemina infection in calves". The British veterinary journal. 131 (6): 666–72. PMID 1212605.

[3] Kuttler, KL (1980). "Pharmacotherapeutics of drugs used in treatment of anaplasmosis and babesiosis". Journal of the American Veterinary Medical Association. 176 (10 Spec No): 1103–8. PMID 7216881.

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