imidazole-5-acetic acid

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  • Imidazole-5-acrylic acids: potent nonpeptide angiotensin II receptor antagonists designed using a novel peptide pharmacophore model.
  • Keenan RM1, Weinstock J, Finkelstein JA, Franz RG, Gaitanopoulos DE, Girard GR, Hill DT, Morgan TM, Samanen JM, Hempel J, et al.
  • Journal of medicinal chemistry.J Med Chem.1992 Oct 16;35(21):3858-72.
  • A series of novel nonpeptide angiotensin II receptor antagonists containing a substituted (E)-acrylic acid has been developed. The overlay of 1, an imidazole-5-acetic acid found in the patent literature, on a novel pharmacophore model of AII suggested that extension of the acid side chain and attach
  • PMID 1433195
  • Blockade of the pre- and postjunctional effects of angiotensin in vivo with a non-peptide angiotensin receptor antagonist.
  • Jackson EK1, Inagami T.
  • Life sciences.Life Sci.1990;46(13):945-53.
  • Recent reports indicate that some imidazole-5-acetic acid derivatives are competitive antagonists of angiotensin II receptors. However, to our knowledge, there is no published information regarding: 1) what constant infusion rate of these non-peptide angiotensin receptor blockers is necessary to eff
  • PMID 2329920
  • Non-peptide angiotensin II receptor antagonists. II. Pharmacology of S-8308.
  • Chiu AT1, Carini DJ, Johnson AL, McCall DE, Price WA, Thoolen MJ, Wong PC, Taber RI, Timmermans PB.
  • European journal of pharmacology.Eur J Pharmacol.1988 Nov 15;157(1):13-21.
  • 2-Butyl-4-chloro-1-(2-nitrobenzyl)imidazole-5-acetic acid, sodium salt (S-8308), inhibited the specific binding of labeled angiotensin II (AII) to its receptor sites in rat adrenal cortical microsomes and in cultured aortic smooth muscle cells with IC50S of 15 and 4.5 microM, respectively. In the pr
  • PMID 3234494


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「street name for lysergic acid diethylamide」
back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen

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「any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt」

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「having the characteristics of an acid; "an acid reaction"」

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「酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD」



  • adj.
  • 酢酸の
acetateacetic acidAcOHCH3COOH

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「relating to or containing acetic acid」

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「an organic base C3H4N2; a histamine inhibitor」
iminazole, glyoxaline