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1. アナフィラキシーの臨床診断を裏付ける臨床検査 laboratory tests to support the clinical diagnosis of anaphylaxis
2. 資源の限られた状況における子宮頸癌のスクリーニング screening for cervical cancer in resource limited settings
3. 子宮頸癌スクリーニング検査：目視検査法 cervical cancer screening tests visual inspection methods
4. 色素内視鏡検査 chromoendoscopy
5. 大腸癌の肝転移に対する非外科的局所治療戦略 nonsurgical local treatment strategies for colorectal cancer liver metastases

English Journal

Imidazole-5-acrylic acids: potent nonpeptide angiotensin II receptor antagonists designed using a novel peptide pharmacophore model.

Keenan RM1, Weinstock J, Finkelstein JA, Franz RG, Gaitanopoulos DE, Girard GR, Hill DT, Morgan TM, Samanen JM, Hempel J, et al.
Journal of medicinal chemistry.J Med Chem.1992 Oct 16;35(21):3858-72.
A series of novel nonpeptide angiotensin II receptor antagonists containing a substituted (E)-acrylic acid has been developed. The overlay of 1, an imidazole-5-acetic acid found in the patent literature, on a novel pharmacophore model of AII suggested that extension of the acid side chain and attach
PMID 1433195

Blockade of the pre- and postjunctional effects of angiotensin in vivo with a non-peptide angiotensin receptor antagonist.

Jackson EK1, Inagami T.
Life sciences.Life Sci.1990;46(13):945-53.
Recent reports indicate that some imidazole-5-acetic acid derivatives are competitive antagonists of angiotensin II receptors. However, to our knowledge, there is no published information regarding: 1) what constant infusion rate of these non-peptide angiotensin receptor blockers is necessary to eff
PMID 2329920

Chiu AT1, Carini DJ, Johnson AL, McCall DE, Price WA, Thoolen MJ, Wong PC, Taber RI, Timmermans PB.
European journal of pharmacology.Eur J Pharmacol.1988 Nov 15;157(1):13-21.
2-Butyl-4-chloro-1-(2-nitrobenzyl)imidazole-5-acetic acid, sodium salt (S-8308), inhibited the specific binding of labeled angiotensin II (AII) to its receptor sites in rat adrenal cortical microsomes and in cultured aortic smooth muscle cells with IC50S of 15 and 4.5 microM, respectively. In the pr
PMID 3234494