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TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.

Edman S, McKay S, Macdonald LJ, Samadi M, Livesey MR, Hardingham GE, Wyllie DJ.SourceCentre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK; Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, SE 405 30 Gothenburg, Sweden.
Neuropharmacology.Neuropharmacology.2012 Sep;63(3):441-9. Epub 2012 May 1.
Antagonists that are sufficiently selective to preferentially block GluN2A-containing N-methyl-d-aspartate receptors (NMDARs) over GluN2B-containing NMDARs are few in number. In this study we describe a pharmacological characterization of 3-chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl
PMID 22579927

Peri-infarct Blood-brain Barrier Dysfunction Facilitates Induction of Spreading Depolarization Associated with Epileptiform Discharges.

Lapilover EG, Lippman K, Salar S, Maslarova A, Dreier JP, Heinemann U, Friedman A.SourceInstitute of Neurophysiology, Charité Universitätsmedizin, 13347 Berlin, Germany.
Neurobiology of disease.Neurobiol Dis.2012 Jul 7. [Epub ahead of print]
Recent studies showed that spreading depolarizations (SDs) occur abundantly in patients following ischemic stroke and experimental evidence suggests that SDs recruit tissue at risk into necrosis. We hypothesized that BBB opening with consequent alterations of the extracellular electrolyte compositio
PMID 22782081

中村智実,内山真一郎,山崎昌子,金京子,岩田誠,尾崎由基男
日本血栓止血学会誌 = The Journal of Japanese Society on Thrombosis and Hemostasis 10(2), 141-148, 1999-06-01
NAID 10008633537

斉藤清,真辺達男,入野理
日本薬理学雑誌 91(2), 105-109, 1988
… ifenprodil tartrateのマウスin vivoおよびヒトex vivo血小板凝集抑制作用の発現様式についての研究を行なった．マウスの血漿中ifenprodilレベルはifenprodil tartrate 30mg/kg経口投与20分後に最高値に達し，投与3時間後にかけて減衰した．一方，最大抑制作用は投与1時間後にみられた．このようにifenprodil tartrateは血 …
NAID 130000759400