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  • Investigation of the antifibrillatory drug interactions between Amiodarone and Ibutilide in isolated, perfused Rabbit hearts.
  • Almotrefi AA1, Bukhari IA1, Alhumayyd MS1.
  • Fundamental & clinical pharmacology.Fundam Clin Pharmacol.2015 Aug 24. doi: 10.1111/fcp.12141. [Epub ahead of print]
  • In view of the reliability of the serial-shock method of measuring ventricular fibrillation threshold (VFT) in quantitatively assessing the antifibrillatory potency of many anti-arrhythmic drugs and the alarming reports of the proarrhythmic effects of several anti-arrhythmic agents, it was decided t
  • PMID 26301534
  • Contemporary analysis of incidence of post-operative atrial fibrillation, its predictors, and association with clinical outcomes in lung transplantation.
  • Raghavan D1, Gao A2, Ahn C2, Torres F3, Mohanka M3, Bollineni S3, Peltz M4, Wait M4, Ring S4, Kaza V3.
  • The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.J Heart Lung Transplant.2015 Apr;34(4):563-70. doi: 10.1016/j.healun.2014.09.032. Epub 2014 Sep 28.
  • BACKGROUND: Atrial fibrillation (AF) is a common complication after lung transplantation (LT). Since the lung allocation score (LAS) was implemented in 2005, there has been significant evolution in the practice of LT, necessitating re-evaluation of this arrhythmia.METHODS: One hundred thirty-one pat
  • PMID 25476846
  • Increasing gap junction coupling suppresses ibutilide-induced torsades de pointes.
  • Ruan L1, Quan X1, Li L1, Bai R2, Ni M1, Xu R1, Zhang C1.
  • Experimental and therapeutic medicine.Exp Ther Med.2014 May;7(5):1279-1284. Epub 2014 Mar 4.
  • Drug-induced torsades de pointes (TdP) is common with class III antiarrhythmic drugs. Increased transmural dispersion of repolarization (TDR) contributes significantly to the development of TdP. Gap junctions play an important role in maintaining TDR in long QT syndrome. The present study examined t
  • PMID 24940425


  • Effects of Quinidine on the Action Potential Duration Restitution Property in the Right Ventricular Outflow Tract in Patients With Brugada Syndrome
  • Circulation journal : official journal of the Japanese Circulation Society 75(9), 2080-2086, 2011-08-25
  • … RVOT monophasic action potentials (MAPs) were recorded before and after intravenous administration of quinidine (n=6) or ibutilide (n=3). … Both quinidine and ibutilide increased steady-state and minimum RVOT MAP duration during programmed stimulation. …
  • NAID 10029339256
  • The Efficacy and Characteristics of Intraprocedural Use of Ibutilide during Stepwise Linear Catheter Ablation of Persistent Atrial Fibrillation
  • Shi Rui,Yang Long,Yao Yan,H. Zheng Li,S. Chen Wen,Huang Wen,R. Bao Jing,Zhang Shu
  • Journal of Arrhythmia 27(Supplement), BPC_2-BPC_2, 2011
  • Ibutilide is commonly used for acute conversion of atrial fibrillation (AF) and flutter. … The purpose of this study was to determine the efficacy and safety of ibutilide for the rapid conversion of persistent AF during the procedure of radiofrequency catheter ablation (RFCA).<BR><B>Methods:</B> … Ibutilide was administered intravenously to 58 consecutive persistent AF patients which failed to restore sinus rhythm (SR) after extensive linear RFCA. …
  • NAID 130002129557
  • Molecular Determinants of hERG Channel Block by Terfenadine and Cisapride
  • Kamiya Kaichiro,Niwa Ryoko,Morishima Mikio [他],HONJO Haruo,SANGUINETTI Michael C.
  • Journal of pharmacological sciences 108(3), 301-307, 2008-11-20
  • … Unlike methanesulfonanilides (dofetilide, MK-499, E-4031, ibutilide) or clofilium, mutation of V625, G648, or V659 did not alter the sensitivity of hERG channels to terfenadine or cisapride. …
  • NAID 10024593080


Clinical Studies Two full-length, peer-reviewed articles have been published to support the clinical efficacy of ibutilide, 9 10 whereas other data have appeared in abstract form or from the pharmaceutical sponsor. 24 The first major ...
Murray KT. Ibutilide. Circulation 1998; 97:493. Cimini MG, Brunden MN, Gibson JK. Effects of ibutilide fumarate, a novel antiarrhythmic agent, and its enantiomers on isolated rabbit myocardium. Eur J Pharmacol 1992; 222:93. Glatter ...


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拡張検索ibutilide fumarate



ibutilideibutilide fumarate

ibutilide fumarate」