イブフェナク、イブフェナック
English Journal
- Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage?
- Bessone F.AbstractNon-steroidal anti-inflammatory drugs (NSAIDs) constitute a family of drugs, which taken as a group, represents one of the most frequently prescribed around the world. Thus, not surprisingly NSAIDs, along with anti-infectious agents, list on the top for causes of Drug-Induced Liver Injury (DILI). The incidence of liver disease induced by NSAIDs reported in clinical studies is fairly uniform ranging from 0.29/100 000 [95% confidence interval (CI): 0.17-051] to 9/100 000 (95% CI: 6-15). However, compared with these results, a higher risk of liver-related hospitalizations was reported (3-23 per 100 000 patients). NSAIDs exhibit a broad spectrum of liver damage ranging from asymptomatic, transient, hyper-transaminasemia to fulminant hepatic failure. However, under-reporting of asymptomatic, mild cases, as well as of those with transient liver-tests alteration, in conjunction with reports non-compliant with pharmacovigilance criteria to ascertain DILI and flawed epidemiological studies, jeopardize the chance to ascertain the actual risk of NSAIDs hepatotoxicity. Several NSAIDs, namely bromfenac, ibufenac and benoxaprofen, have been withdrawn from the market due to hepatotoxicity; others like nimesulide were never marketed in some countries and withdrawn in others. Indeed, the controversy concerning the actual risk of severe liver disease persists within NSAIDs research. The present work intends (1) to provide a critical analysis of the dissimilar results currently available in the literature concerning the epidemiology of NSAIDS hepatotoxicity; and (2) to review the risk of hepatotoxicity for each one of the most commonly employed compounds of the NSAIDs family, based on past and recently published data.
- World journal of gastroenterology : WJG.World J Gastroenterol.2010 Dec 7;16(45):5651-61.
- Non-steroidal anti-inflammatory drugs (NSAIDs) constitute a family of drugs, which taken as a group, represents one of the most frequently prescribed around the world. Thus, not surprisingly NSAIDs, along with anti-infectious agents, list on the top for causes of Drug-Induced Liver Injury (DILI). Th
- PMID 21128314
- Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides.
- Johnson CH, Karlsson E, Sarda S, Iddon L, Iqbal M, Meng X, Harding JR, Stachulski AV, Nicholson JK, Wilson ID, Lindon JC.SourceBiomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK.
- Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2010 Jan;40(1):9-23. doi: 10.3109/00498250903348720.
- Acyl glucuronides (AGs) are common, chemically reactive metabolites of acidic xenobiotics. Concerns about the potential of this class of conjugate to cause toxicity in man require efficient methods for the determination of reactivity, and this is commonly done by measuring transacylation kinetics. H
- PMID 19919325
- A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience.
- Goldkind L, Laine L.SourceUniformed Services University for Health Sciences Bethesda, MD 20854, USA.
- Pharmacoepidemiology and drug safety.Pharmacoepidemiol Drug Saf.2006 Apr;15(4):213-20.
- Drug-induced hepatotoxicity is the leading cause of acute liver failure (ALF) in the US and the most common adverse event causing drug non-approval and drug withdrawal by the U.S. Food and Drug Administration (FDA). Three different nonsteroidal anti-inflammatory drugs (NSAIDs) have been withdrawn in
- PMID 16456879
Japanese Journal
- Comparative Study of the Interaction between Sulfamethizole and Ibufenac, Sulindac or Mepirizole at the Renal Level in Rats(Pharmaceutical,Chemical)
- 千葉 一基,菊地 敏,美濃 興三,西村 成勲,宮崎 正三,高田 昌彦
- Chemical & pharmaceutical bulletin 35(11), 4650-4655, 1987-11-25
- … The effects of three non-steroidal anti-inflammatory drugs, ibufenac, sulindac and mepirizole, on the renal excretion of sulfamethizole in rats were investigated, in order to clarify the mechanisms involved. … The clearance ratio of sulfamethizole was markedly decreased after infusion of ibufenac, while sulindac or mepirizole had no effect on the clearance ratio of sulfamethizole. …
- NAID 110006281678
- Synthesis of Ethyl Arylacetates by Means of Friedel-Crafts Reaction of Aromatic Compounds with Ethyl α-Chloro-α-(methylthio) acetate
- 田村 恭光,CHOI HONGDAE,新堂 裕久,石橋 弘行
- Chemical & pharmaceutical bulletin 30(3), 915-921, 1982-03-25
- … The reactions were applied to the syntheses of ibufenac (5) and alclofenac (6), which are anti-inflammatory agents. …
- NAID 110003634369
- INFLUENCE OF SOME ANTI-INFLAMMATORY, ANTIPYRETIC AND ANALGESIC AGENTS ON URINARY ENZYME LEVEL IN RATS
- TSURUMI Kaito,ABE Akira,NOZAKI Masakatsu,FUJIMURA Hajime
- The Journal of Toxicological Sciences 3(1), 1-9, 1978-02-15
- … Other drugs such as sodium salicylate, ibufenac, ibuprofen, bucolome, aminopropylone, sulfinpyrazone, benzydamine and mepirizole did not significantly influence any enzyme activities measured in urine. …
- NAID 110001803904
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