hyposegmentation

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1. 好酸球増加症候群の臨床症状、病態生理、および診断 clinical manifestations pathophysiology and diagnosis of the hypereosinophilic syndromes

Vale AM1, Tomaz LR, Sousa RS, Soto-Blanco B.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.J Vet Diagn Invest.2011 Jul;23(4):863-5. doi: 10.1177/1040638711407891. Epub 2011 Jun 15.
A 6-month-old male mixed-breed dog weighing 12.6 kg weight was presented for evaluation of a subcutaneous nodule on the dorsum. The medical history indicated trimethoprim-sulfamethoxazole treatment 2 months before presentation at the veterinary hospital. The initial complete blood cell count (CBC) r
PMID 21908340

Dusse LM1, Moreira AM, Vieira LM, Rios DR, Silva RM, Carvalho Md.
Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2010 Nov 11;411(21-22):1587-90. doi: 10.1016/j.cca.2010.07.011. Epub 2010 Aug 5.
Pelger-Huët anomaly (PHA) is a benign inherited condition characterized by hyposegmentation of the neutrophil's nucleus and excessive chromatin clumping. An acquired neutrophil dysplasia similar to PHA has been described in hematological diseases and in some clinical conditions. It has been known a
PMID 20691170

Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein.

Clayton P1, Fischer B, Mann A, Mansour S, Rossier E, Veen M, Lang C, Baasanjav S, Kieslich M, Brossuleit K, Gravemann S, Schnipper N, Karbasyian M, Demuth I, Zwerger M, Vaya A, Utermann G, Mundlos S, Stricker S, Sperling K, Hoffmann K.
Nucleus (Austin, Tex.).Nucleus.2010 Jul-Aug;1(4):354-66. doi: 10.4161/nucl.1.4.12435. Epub 2010 May 21.
The lamin B receptor (LBR) is an inner nuclear membrane protein with a structural function interacting with chromatin and lamins, and an enzymatic function as a sterol reductase. Heterozygous LBR mutations cause nuclear hyposegmentation in neutrophils (Pelger anomaly), while homozygous mutations cau
PMID 21327084

久末正晴,土屋亮,山田隆紹
麻布大学雑誌 13/14, 155-159, 2006
骨髄異形成症候群(MDS)は,白血球,赤血球および血小板の血球減少が認められ,さらに高頻度に急性白血病への進行が認められる前白血病段階の疾患である。しかしながら,犬のMDSにおける診断および治療法についてはまだ明らかとなっていないことが多い。そこで我々はMDSと診断されたイヌ9例について血液異常について検討を行ない,さらに近年白血病細胞の分化誘導薬として期待されているビタミンK2の治療効果を血液学 …
NAID 110006391508