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English Journal
- Critical illness-induced bone loss is related to deficient autophagy and histone hypomethylation.
- Owen HC1, Vanhees I, Gunst J, Van Cromphaut S, Van den Berghe G.
- Intensive care medicine experimental.Intensive Care Med Exp.2015 Dec;3(1):52. doi: 10.1186/s40635-015-0052-3. Epub 2015 Jun 21.
- BACKGROUND: Survivors of critical illness are at increased risk of fractures. This may be due to increased osteoclast formation during critical illness, leading to trabecular bone loss. Such bone loss has also been observed in Paget's disease, and has been related to deficient autophagy. Deficient a
- PMID 26215816
- Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer.
- Hubaux R1, Thu KL1, Vucic EA1, Pikor LA1, Kung SH1, Martinez VD1, Mosslemi M1, Becker-Santos DD1, Gazdar AF2, Lam S1, Lam WL1.
- International journal of cancer. Journal international du cancer.Int J Cancer.2015 Nov 1;137(9):2072-82. doi: 10.1002/ijc.29577. Epub 2015 May 6.
- Microtubule affinity-regulating kinases (MARKs) are involved in several cellular functions but few studies have correlated MARK kinase expression with cancer, and none have explored their role in lung cancer. In this study, we identified MARK2 as frequently disrupted by DNA hypomethylation and copy
- PMID 25907283
- Loss of epigenetic silencing of the DUX4 transcription factor gene in facioscapulohumeral muscular dystrophy.
- Hewitt JE1.
- Human molecular genetics.Hum Mol Genet.2015 Oct 15;24(R1):R17-23. doi: 10.1093/hmg/ddv237. Epub 2015 Jun 25.
- Current genetic and molecular evidence best supports an epigenetic mechanism for facioscapulohumeral muscular dystrophy (FSHD), whereby de-repression of the D4Z4 macrosatellite array leads to aberrant expression of the DUX4 transcription factor in skeletal muscle. This de-repression is triggered by
- PMID 26113644
Japanese Journal
- Epigenetic and genetic alterations of the imprinting disorder Beckwith-Wiedemann syndrome and related disorders (Special Section on Epigenomics : biological understanding and clinical application)
- Soejima Hidenobu,Higashimoto Ken
- Journal of human genetics 58(7), 402-409, 2013-07
- NAID 40019704935
- LINE-1 hypomethylation in gastric cancer, detected by bisulfite pyrosequencing, is associated with poor prognosis
- Shigaki Hironobu,Baba Yoshifumi,Watanabe Masayuki [他]
- Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 16(4), 480-487, 2013
- NAID 40019845213
- Potential Mechanisms of Aberrant DNA Hypomethylation on the X Chromosome in Uterine Leiomyomas
- SATO Shun,MAEKAWA Ryo,YAMAGATA Yoshiaki,ASADA Hiromi,TAMURA Isao,LEE Lifa,OKADA Maki,TAMURA Hiroshi,SUGINO Norihiro
- Journal of Reproduction and Development, 2013
- … We recently found that aberrant DNA hypomethylation is more common on the X chromosome than on other chromosomes in uterine leiomyomas by genome-wide DNA methylation profiling. … To investigate the mechanism of aberrant hypomethylation on the X chromosome in uterine leiomyomas, we analyzed methylome and transcriptome data from three cases of leiomyomas and the adjacent myometrium. …
- NAID 130003381861
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- hypomethylation 【名】低メチル化 - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。
- hypomethylation (plural hypomethylations) (genetics) a decrease in the epigenetic methylation of cytosine and adenosine residues in DNA Antonyms [edit] hypermethylation Related terms [edit] hypomethylated Retrieved from "" : ...
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- hypomethylation、hypomethylated