English Journal

Sleep-inducing factors.

García-García F1, Acosta-Peña E, Venebra-Muñoz A, Murillo-Rodríguez E.
CNS & neurological disorders drug targets.CNS Neurol Disord Drug Targets.2009 Aug;8(4):235-44.
Kuniomi Ishimori and Henri Piéron were the first researchers to introduce the concept and experimental evidence for a chemical factor that would presumably accumulate in the brain during waking and eventually induce sleep. This substance was named hypnotoxin. Currently, the variety of substances wh
PMID 19689305

[The discovery of anaphylaxis, a brief but triumphant encounter of two physiologists (1902)].

Richet G.
Histoire des sciences médicales.Hist Sci Med.2003 Oct-Dec;37(4):463-9.
In 1901, during one of his oceanography cruises, Prince Albert the First of Monaco asks Paul Portier and Charles Richet to study the toxicity of small jellyfish fishing filaments (Coelentera). In the course of their work on the effects of a hypnotoxin extracted from various coelentera, they observe
PMID 14989211

[The history of sleep research in the 20th century].

Mathis J1.
Praxis.Praxis (Bern 1994).1995 Dec 12;84(50):1479-85.
Not until the 19th century theories on sleep were based upon experimental findings in animal and humans. The so-called 'hypnotoxin theory' culminated, when Legendre and Piéron successfully induced sleep in a dog by transmission of cerebrospinal fluid from a dog deprived of sleep. The main discussio
PMID 8539501

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