WordNet
- pathological sensitivity
- extreme sensitivity
- inflammation of a blood vessel or lymph duct
PrepTutorEJDIC
- 過敏,過敏症
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/12 13:12:59」(JST)
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- 1. 成人における過敏性血管炎 hypersensitivity vasculitis in adults
- 2. 成人の血管炎の分類とそれに対するアプローチ classification of and approach to the vasculitides in adults
- 3. 成人における血管炎のマネージメントの概要 overview of the management of the vasculitides in adults
- 4. 成人の特発性皮膚小血管性血管炎患者のマネージメント management of adults with idiopathic cutaneous small vessel vasculitis
- 5. リウマチ性血管炎の治療 treatment of rheumatoid vasculitis
English Journal
- The diagnosis and classification of Henoch-Schönlein purpura: An updated review.
- Yang YH1, Yu HH1, Chiang BL2.Author information 1Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.2Department of Medical Research, National Taiwan University Hospital, Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: gicmbor@ntu.edu.tw.AbstractHenoch-Schönlein purpura (HSP) is a common childhood systemic vasculitis with clinical characteristics of cutaneous palpable purpura, arthralgia/arthritis, bowel angina, and hematuria/proteinuria. HSP is identified mainly based on the above presentations. Combined with pathohistological findings of leukocytoclastic vasculitis (LCV) and IgA-immune deposits in vessel walls and/or glomeruli increase the diagnostic sensitivity and specificity. However, considering the accessibility of biopsy and some patients with atypical presentations, there are still medical unmet needs in HSP diagnosis. This article reviews the diagnosis of HSP including the aspects of classification criteria, differential diagnosis, and some laboratory findings as the biomarkers with diagnostic potential.
- Autoimmunity reviews.Autoimmun Rev.2014 Jan 12. pii: S1568-9972(14)00043-3. doi: 10.1016/j.autrev.2014.01.031. [Epub ahead of print]
- Henoch-Schönlein purpura (HSP) is a common childhood systemic vasculitis with clinical characteristics of cutaneous palpable purpura, arthralgia/arthritis, bowel angina, and hematuria/proteinuria. HSP is identified mainly based on the above presentations. Combined with pathohistological findings of
- PMID 24424188
- Blocking von Willebrand factor for treatment of cutaneous inflammation.
- Hillgruber C1, Steingräber AK2, Pöppelmann B2, Denis CV3, Ware J4, Vestweber D5, Nieswandt B6, Schneider SW7, Goerge T1.Author information 11] Department of Dermatology, University Hospital of Münster, Münster, Germany [2] Interdisciplinary Center for Clinical Research (IZKF), University of Münster, Münster, Germany.2Department of Dermatology, University Hospital of Münster, Münster, Germany.3Inserm U770, Université Paris Sud, Paris, France.4Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.5Department of Vascular Cell Biology, Max Planck Institute of Molecular Biomedicine, Münster, Germany.6Rudolf Virchow Center, University of Würzburg, Würzburg, Germany.7Department of Dermatology, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany.AbstractVon Willebrand factor (VWF), a key player in hemostasis, is increasingly recognized as a proinflammatory protein. Here, we found a massive accumulation of VWF in skin biopsies of patients suffering from immune complex (IC)-mediated vasculitis (ICV). To clarify the impact of VWF on cutaneous inflammation, we induced experimental ICV either in mice treated with VWF-blocking antibodies or in VWF(-/-) mice. Interference with VWF led to a significant inhibition of the cutaneous inflammatory response. We confirmed the major findings in irritative contact dermatitis, a second model of cutaneous inflammation. In vivo imaging of cutaneous inflammation in the dorsal skinfold chamber revealed unaffected leukocyte rolling on anti-VWF treatment. However, we identified that reduced leukocyte recruitment is accompanied by reduced vascular permeability. Although VWF-mediated neutrophil recruitment to the peritoneum was described to require the VWF receptor on platelets (glycoprotein Ibα (GPIbα)), the VWF/GPIbα axis was dispensable for cutaneous inflammation. As assessed in tail bleeding assays, we could exclude interference of VWF blockade with hemostasis. Of particular importance, anti-VWF treatment was effective both in prophylactic and therapeutic administration. Thus, VWF represents a promising target for the treatment of cutaneous inflammation, e.g., leukocytoclastic vasculitis.
- The Journal of investigative dermatology.J Invest Dermatol.2014 Jan;134(1):77-86. doi: 10.1038/jid.2013.292. Epub 2013 Jun 28.
- Von Willebrand factor (VWF), a key player in hemostasis, is increasingly recognized as a proinflammatory protein. Here, we found a massive accumulation of VWF in skin biopsies of patients suffering from immune complex (IC)-mediated vasculitis (ICV). To clarify the impact of VWF on cutaneous inflamma
- PMID 23812299
- Urticarial vasculitis in northern Spain: clinical study of 21 cases.
- Loricera J, Calvo-Río V, Mata C, Ortiz-Sanjuán F, González-López MA, Alvarez L, González-Vela MC, Armesto S, Fernández-Llaca H, Rueda-Gotor J, González-Gay MA, Blanco R.Author information From Divisions of Rheumatology (JL, VC-R, CM, FO-S, JR-G, MAG-G, RB), Dermatology (MAG-L, SA, HF-L), Pediatrics (LA), and Pathology (MCG-V), Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain.AbstractUrticarial vasculitis (UV) is a subset of cutaneous vasculitis (CV), characterized clinically by urticarial skin lesions of more than 24 hours' duration and histologically by leukocytoclastic vasculitis. We assessed the frequency, clinical features, treatment, and outcome of a series of patients with UV. We conducted a retrospective study of patients with UV included in a large series of unselected patients with CV from a university hospital. Of 766 patients with CV, UV was diagnosed in 21 (2.7%; 9 male and 12 female patients; median age, 35 yr; range, 1-78 yr; interquartile range, 5-54 yr). Eight of the 21 cases were aged younger than 20 years old. Potential precipitating factors were upper respiratory tract infections and drugs (penicillin) (n = 4; in all cases in patients aged <20 yr), human immunodeficiency virus (HIV) infection (n = 1), and malignancy (n = 1). Besides urticarial lesions, other features such as palpable purpura (n = 7), arthralgia and/or arthritis (n = 13), abdominal pain (n = 2), nephropathy (n = 2), and peripheral neuropathy (n = 1) were observed. Hypocomplementemia (low C4) with low C1q was disclosed in 2 patients. Other abnormal laboratory findings were leukocytosis (n = 7), increased erythrocyte sedimentation rate (n = 6), anemia (n = 4), and antinuclear antibody positivity (n = 2). Treatment included corticosteroids (n = 12), antihistaminic drugs (n = 6), chloroquine (n = 4), nonsteroidal antiinflammatory drugs (n = 3), colchicine (n = 2), and azathioprine (n = 1). After a median follow-up of 10 months (interquartile range, 2-38 mo) recurrences were observed in 4 patients. Apart from 1 patient who died because of an underlying malignancy, the outcome was good with full recovery in the remaining patients. In conclusion, our results indicate that UV is rare but not exceptional. In children UV is often preceded by an upper respiratory tract infection. Urticarial lesions and joint manifestations are the most frequent clinical manifestation. Low complement serum levels are observed in a minority of cases. The prognosis is generally good, but depends on the underlying disease.
- Medicine.Medicine (Baltimore).2014 Jan;93(1):53-60. doi: 10.1097/MD.0000000000000013.
- Urticarial vasculitis (UV) is a subset of cutaneous vasculitis (CV), characterized clinically by urticarial skin lesions of more than 24 hours' duration and histologically by leukocytoclastic vasculitis. We assessed the frequency, clinical features, treatment, and outcome of a series of patients wit
- PMID 24378743
Japanese Journal
- Experimental granulomatous vasculitis induced by sensitization with Ascaris suum antigen in mice
- ALWIE Mappiasse Lallo,WAKAKI Kunihiko,KURASHIGE Yoichi,KOIZUMI Fumitomo
- Pathology international 45(12), 914-924, 1995-12-01
- NAID 10008332143
- 両下肢の激しいとう痛と壊死性皮膚症状を呈したＣｈｕｒｇ‐Ｓｔｒａｕｓｓ ｓｙｎｄｒｏｍｅの１例
- 田中 康子,武藤 始,秋山 法久,荒井 康男,宮本 康文,佐野 靖之
- 日本胸部疾患学会雑誌 32(9), 873-877, 1994
- 症例は68歳女性, 気管支喘息のため治療中. 既往歴に薬剤アレルギーがある. 両下肢の疼痛, 腫脹, しびれ感を主訴に当院受診. 末梢血好酸球が53.5%と上昇しており, アレルギー性肉芽腫性血管炎と診断し入院, PSL 30mg/日投与を開始した. PSL投与翌日の皮膚生検像で壊死性血管炎と好酸球の extravasation, 蛍光抗体法でIgGが小血管壁に沈着していた. PSL約30mg/日 …
- NAID 130003678482
- 胆道感染症を起因とした肝壊死性血管炎の１剖検例
- 安部 行弘,戸部 和夫,薄元 亮二,友田 純,糸島 達也,長島 秀夫,三村 久,香川 晃一,林 肇輝,粟井 通泰
- 肝臓 28(1), 104-108, 1987
- 壊死性血管炎は感染症もその一因となる.最近我々は肝生検にて壊死性血管炎の像を認め,胆道感染症に随伴した過敏性血管炎の1例を経験したので報告する.症例は73歳,女性で,発熱・四肢のしびれ感を主訴に来院した.入院後種々の抗生物質投与にても解熱せず,腹部レ線でpneumobilia様陰影がみられ,ERCPで総胆管内に結石像を認めた.胆道感染を伴う総胆管結石の診断で胆石除去術を施行し,術中肝生検で壊死性血 …
- NAID 130000881118
Related Links
- Definition of hypersensitivity angiitis in the Medical Dictionary. hypersensitivity angiitis explanation. Information about hypersensitivity angiitis in Free online English dictionary. What is hypersensitivity angiitis? Meaning of forum ...
- hy·per·sen·si·tive (h p r-s n s-t v) adj. Highly or excessively sensitive. hy per·sen si·tive·ness, hy per·sen si·tiv i·ty (-t v-t) n. hypersensitivity extreme or abnormal sensitivity, as to criticism. — hypersensitive, adj. See also: Psychology
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★リンクテーブル★
| リンク元 | 「アレルギー性血管炎」「leukocytoclastic angiitis」 |
| 関連記事 | 「hypersensitivity」 |