WordNet
- serve in a specific professional capacity; "the priest sat for confession"; "she sat on the jury"
- be around, often idly or without specific purpose; "The object sat in the corner"; "We sat around chatting for another hour" (同)sit around
- be seated (同)sit_down
- be in session; "When does the court of law sit?"
- be located or situated somewhere; "The White House sits on Pennsylvania Avenue"
- the piece of land on which something is located (or is to be located); "a good site for the school" (同)land site
- physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides" (同)situation
PrepTutorEJDIC
- (…に)『座る』,座っている《+『at』(『on, in』)+『名』》・着席する《+『down』》・(…に)〈鳥などが〉『止まる』,休む《+『on』+『名』》・〈めんどりが〉卵を抱く,巣に就く / 《場所の副詞[句]を伴って》(ある場所に)『位置する』・ (画家・写真家のために)ポーズをとる・しっとしている,動かないでいる・(議員・委員などの)職に就いている《+『on』+『名』》・〈議会・法廷などが〉開会(開廷)される・(…に)負担となる,重荷となる《+『on』(『upon』)+『名』》・〈衣服などが〉(…に)合う,似合う《+『on』+『名』》・〈人〉‘を'座らせる,着席させる《+『down』+『名,』+『名』+『down』》・〈馬〉‘に'乗る・《英》〈試験〉‘を'受ける
- (町・建物などの)『場所』;敷地,用地 / 遺跡;(事件などの)現場 / 〈建物など〉‘を'位置させる(locate)
- (…に)敏感すぎる,過敏性の《+『to』(『about』)+『名』》
- =ti
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/08/08 18:23:49」(JST)
[Wiki en表示]
A hypersensitive site is a short region of chromatin and is detected by its super sensitivity to cleavage by DNase I and other various nucleases (DNase II and micrococcal nucleases). In a hypersensitive site, the nucleosomal structure is not organized in the usual fashion, which results in a 100 fold increase in sensitivity to enzyme attack than in bulk chromatin.
Location
Hypersensitive sites are found on every active gene, and many of these genes often have more than one hypersensitive site. Most often, hypersensitive sites are found only in chromatin of cells in which the associated gene is being expressed, and do not occur when the gene is inactive.
In DNA being transcribed, 5' hypersensitive sites appear before transcription begins, and the DNA sequences within the hypersensitive sites are required for gene expression. Note: hypersensitive sites precede active promoters.
Hypersensitive sites are generated as a result of the binding of transcription factors that displace histone octamers.
They can also be located by indirect end labelling. A fragment of DNA is cut once at the hypersensitive site with DNase and at another site with a restriction enzyme. The distance from the known restriction site to the DNase cut is then measured to give the location.
UpToDate Contents
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Japanese Journal
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- Journal of human genetics 59(10), 585-587, 2014-10
- NAID 40020248145
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Related Links
- In genetics a hypersensitive site is a short region of chromatin and is detected by its super sensitivity to cleavage by DNase I and other various nucleases (DNase II and micrococcal nucleases). In a hypersensitive site, the nucleosomal ...
- DNase 1 hypersensitive sites are the first place this nuclease introduces a double -strand break in chromatin (see DNase 1 Sensitivity). These sites usually involve small segments of DNA sequences (100 to 200 bp) and are two or more orders ...
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- hyperesthesia、hyperesthetic、hyperreactivity、hypersensitivity、overactive、overactivity、supersensitive
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