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  • The effect of hyperpolarization-activated cyclic nucleotide-gated ion channel inhibitors on the vagal control of guinea pig airway smooth muscle tone.
  • McGovern AE1, Robusto J, Rakoczy J, Simmons DG, Phipps S, Mazzone SB.
  • British journal of pharmacology.Br J Pharmacol.2014 Aug;171(15):3633-50. doi: 10.1111/bph.12745.
  • BACKGROUND AND PURPOSE: Subtypes of the hyperpolarization-activated cyclic nucleotide-gated (HCN) family of cation channels are widely expressed on nerves and smooth muscle cells in many organ systems, where they serve to regulate membrane excitability. Here we have assessed whether HCN channel inhi
  • PMID 24762027
  • I h and HCN Channels in Murine Spiral Ganglion Neurons: Tonotopic Variation, Local Heterogeneity, and Kinetic Model.
  • Liu Q1, Manis PB, Davis RL.
  • Journal of the Association for Research in Otolaryngology : JARO.J Assoc Res Otolaryngol.2014 Aug;15(4):585-99. doi: 10.1007/s10162-014-0446-z. Epub 2014 Feb 21.
  • One of the major contributors to the response profile of neurons in the auditory pathways is the I h current. Its properties such as magnitude, activation, and kinetics not only vary among different types of neurons (Banks et al., J Neurophysiol 70:1420-1432, 1993; Fu et al., J Neurophysiol 78:2235-
  • PMID 24558054
  • Hippocampal HDAC4 Contributes to Postnatal Fluoxetine-Evoked Depression-Like Behavior.
  • Sarkar A1, Chachra P1, Kennedy P2, Pena CJ2, Desouza LA1, Nestler EJ2, Vaidya VA1.
  • Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.Neuropsychopharmacology.2014 Aug;39(9):2221-32. doi: 10.1038/npp.2014.73. Epub 2014 Mar 25.
  • Fluoxetine treatment in adulthood evokes antidepressant and anxiolytic responses. Paradoxically, postnatal fluoxetine (PNFlx) induces persistent depression- and anxiety-like behaviors. The mechanistic underpinnings of this paradox remain poorly understood. Here, we examined specific molecular change
  • PMID 24663010


  • Laser Original カエル心臓の自動性に対する532/808nm低出力レーザー照射の相反的効果 : Ih(過分極性電位依存性電流)チャネル介在の可能性 (「ニューロフォトニクス:神経科学,脳神経外科学におけるレーザー・光応用」特集号)
  • 野崎 輝夫,井本 信一,荒井 誠一 [他]
  • レーザー研究 40(4), 292-298, 2012-04
  • NAID 40019304643
  • 閾値下共鳴振動現象へのカルシウム依存性K+チャネルの関わり
  • 瀬川 友作,相原 威,北嶋 龍雄
  • 電子情報通信学会技術研究報告. NC, ニューロコンピューティング 110(461), 83-87, 2011-02-28
  • 多くの興奮性/抑制性ニューロンで観測される閾値下共鳴振動は、動物の行動もしくは知覚の状態において重要な役割を果たしていることが示唆されている。短期記憶とワーキングメモリーへの律動的振動の寄与を明らかにするために、これらの振動機能を理解することが必要である。遅延不活性化K^+チャネルや過分極活性型K^+チャネルのような種々の膜電位依存性チャネルは、これらの振動の発生に関与していると考えられている。ま …
  • NAID 110008689827


Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the HCN channel family comprises four members (HCN1-4 ...
Overview: The hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels are cation channels that are activated by hyperpolarization at voltages negative to ~−50 mV. The cyclic nucleotides cAMP and cGMP directly activate ...


dependence of hyperpolarization-activated Figure 5 : Hyperpolarization-activated FIGURE 5 | Development of derivatives of Figure 1: Variability of hyperpolarization including the hyperpolarization-activated  of hyperpolarization-activated channel




  • v.
  • 活性化する、賦活化する、賦活する
activatedactivationturn on

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「aerate (sewage) so as to favor the growth of organisms that decompose organic matter」

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「make (substances) radioactive」

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「make active or more active; "activate an old file"」

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「make more adsorptive; "activate a metal"」

PrepTutorEJDIC   license prepejdic

「…'を'活動的にする / …‘に'放射能を与える / 〈物質〉'を'活性化する」



  • adj.
  • 活性化の、活性化型の、賦活化の
activateactivated formactivationturn on

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「rendered active; e.g. rendered radioactive or luminescent or photosensitive or conductive」

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「(of e.g. a molecule) made reactive or more reactive」

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「(military) set up and placed on active assignment; "a newly activated unit"」

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「(of sewage) treated with aeration and bacteria to aid decomposition」