hyperkeratosis

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角質増生


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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/07/11 15:59:25」(JST)

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英文文献

  • Kyrle's disease.
  • Ataseven A, Ozturk P, Kucukosmanoglu I, Kurtipek GS.Author information Konya Training and Research Hospital, Konya, Turkey.AbstractKyrle's disease (KD) is a dermatosis which was first described by Kyrle as "hyperkeratosis follicularis et parafollicularis in cutem penetrans" in 1916. Perforating dermatoses are a heterogeneous disorder group characterised by transepithelial elimination. KD has been seen in association with multiple disorders, including diabetes mellitus, renal and liver diseases, congestive heart failure, hyperlipidaemia, infective diseases and abnormal metabolism of vitamin A. This case report presents two patients with KD with associated systemic disease.
  • BMJ case reports.BMJ Case Rep.2014 Jan 15;2014. pii: bcr2013009905. doi: 10.1136/bcr-2013-009905.
  • Kyrle's disease (KD) is a dermatosis which was first described by Kyrle as "hyperkeratosis follicularis et parafollicularis in cutem penetrans" in 1916. Perforating dermatoses are a heterogeneous disorder group characterised by transepithelial elimination. KD has been seen in association with multip
  • PMID 24429045
  • Cutaneous Injury-Related Structural Changes and Their Progression following Topical Nitrogen Mustard Exposure in Hairless and Haired Mice.
  • Tewari-Singh N1, Jain AK1, Orlicky DJ2, White CW3, Agarwal R1.Author information 1Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado, United States of America.2Department of Pathology, School of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America.3Department of Pediatrics, School of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America.AbstractTo identify effective therapies against sulfur mustard (SM)-induced skin injuries, various animals have been used to assess the cutaneous pathology and related histopathological changes of SM injuries. However, these efforts to establish relevant skin injury endpoints for efficacy studies have been limited mainly due to the restricted assess of SM. Therefore, we employed the SM analog nitrogen mustard (NM), a primary vesicating and bifunctional alkylating agent, to establish relevant endpoints for efficient efficacy studies. Our published studies show that NM (3.2 mg) exposure for 12-120 h in both the hairless SKH-1 and haired C57BL/6 mice caused clinical sequelae of toxicity similar to SM exposure in humans. The NM-induced cutaneous pathology-related structural changes were further analyzed in this study and quantified morphometrically (as percent length or area of epidermis or dermis) of skin sections in mice showing these lesions. H&E stained skin sections of both hairless and haired mice showed that NM (12-120 h) exposure caused epidermal histopathological effects such as increased epidermal thickness, epidermal-dermal separation, necrotic/dead epidermis, epidermal denuding, scab formation, parakeratosis (24-120 h), hyperkeratosis (12-120 h), and acanthosis with hyperplasia (72-120 h). Similar NM exposure in both mice caused dermal changes including necrosis, edema, increase in inflammatory cells, and red blood cell extravasation. These NM-induced cutaneous histopathological features are comparable to the reported lesions from SM exposure in humans and animal models. This study advocates the usefulness of these histopathological parameters observed due to NM exposure in screening and optimization of rescue therapies against NM and SM skin injuries.
  • PloS one.PLoS One.2014 Jan 8;9(1):e85402. doi: 10.1371/journal.pone.0085402.
  • To identify effective therapies against sulfur mustard (SM)-induced skin injuries, various animals have been used to assess the cutaneous pathology and related histopathological changes of SM injuries. However, these efforts to establish relevant skin injury endpoints for efficacy studies have been
  • PMID 24416404
  • Prevalence of inherited ichthyosis in France: a study using capture-recapture method.
  • Dreyfus I, Chouquet C, Ezzedine K, Henner S, Chiavérini C, Maza A, Pascal S, Rodriguez L, Vabres P, Martin L, Mallet S, Barbarot S, Dupuis J, Mazereeuw-Hautier J.Author information Reference Centre for Rare Skin Diseases, Dermatology Department, Larrey Hospital, CHU Toulouse, Toulouse, France. dreyfus.i@chu-toulouse.fr.AbstractBACKGROUND: Inherited ichthyoses represent a group of rare skin disorders characterized by scaling, hyperkeratosis and inconstant erythema, involving most of the tegument. Epidemiology remains poorly described. This study aims to evaluate the prevalence of inherited ichthyosis (excluding very mild forms) and its different clinical forms in France.
  • Orphanet journal of rare diseases.Orphanet J Rare Dis.2014 Jan 6;9(1):1. doi: 10.1186/1750-1172-9-1.
  • BACKGROUND: Inherited ichthyoses represent a group of rare skin disorders characterized by scaling, hyperkeratosis and inconstant erythema, involving most of the tegument. Epidemiology remains poorly described. This study aims to evaluate the prevalence of inherited ichthyosis (excluding very mild f
  • PMID 24393603

和文文献

  • 糖尿病足潰瘍予防を目的とした足白癬・爪白癬のアセスメントとケア
  • 症例 Hyperkeratosis of Nipple and Areolaの1例
  • 色素失調症(Bloch-Sulzberger Syndrome)の 1 例

関連リンク

Hyperkeratosis - an easy to understand guide covering causes, diagnosis, symptoms, treatment and prevention plus additional in depth medical information. ... Drugs.com provides accurate and independent information on more than ...
Hyperkeratosis is thickening of the stratum corneum (the outermost layer of the epidermis), often associated with the presence of an abnormal quantity of keratin, [1] and also usually accompanied by an increase in the granular layer.

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★リンクテーブル★
リンク元角質増生
拡張検索hyperkeratosis follicularis et parafollicularis in cutem penetrans」「hyperkeratosis congenitalis palmaris et plantaris

角質増生」

  [★]

hyperkeratosis
病的角化

定義

  • 皮膚の角質層が病的に著しく肥厚した状態。

臨床関連


hyperkeratosis follicularis et parafollicularis in cutem penetrans」

  [★] 真皮貫通性毛包性毛包周囲性角質増殖症 キルレ病


hyperkeratosis congenitalis palmaris et plantaris」

  [★] 遺伝性掌蹠角化症




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