過好酸球増加症
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/24 00:01:59」(JST)
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Hypereosinophilia or hypereosinophilic syndrome is a disease characterised by a marked increase in the eosinophil count in the bloodstream.[1]
The eosinophil count in human blood is normally 0.4 × 109/L (0.1 - 0.6) and results from a balance between production of eosinophils and emigration through post-capillary venules (Yamaguchi et al. 1991). Eosinophils are only a small minority of peripheral blood leucocytes and in normal subjects, most are found in the tissues of the lung and gastro-intestinal tract (Beeken et al. 1987). Blood eosinophil counts are arbitrarily classified as mild - between 0.6 to 1.5 × 109/L; moderate between 1.5 to 5 × 109/L and severe when greater than 5 × 109/L.
An elevated blood eosinophil count may be associated with a number of reactive conditions and with clonal disorders of the bone marrow. However, when the blood eosinophil count is persistently greater than 1.5 × 109 /L, for a period of more than six months, damage to end organs such as the heart, lungs, skin, joints and nervous system can be demonstrated, and in the absence of any clonal or reactive cause, the term idiopathic hypereosinophilic syndrome (HES) is used. The three defining criteria of HES are therefore:
- Eosinophil count persistently greater than 1.5 × 109/L
- Damage to end-organs
- No ascertainable cause for the eosinophilia and no evidence of clonality.
There are three categories of blood eosinophilia:
- Reactive (non-clonal) eosinophilia: infections, parasitic infestations, asthma and allergies, respiratory diseases, cytokine infusions, vasculitides, non-haematological malignant diseases, drug reactions and connective tissue diseases, Hodgkin's and non-Hodgkin's lymphomas are included here as the eosinophils have not been shown to be clonal.
- Clonal Disorders of the Bone Marrow associated with eosinophilia: Acute and chronic eosinophilic leukaemia, chronic myeloid leukaemia, polycythaemia rubra vera, essential thrombocythaemia, acute myeloid leukaemia. Chromosome 16 variants, the 8p11 myeloproliferative syndrome (EMS) and T lymphoblastic lymphoma with eosinophilia, acute lymphoblastic leukaemia, myelodysplastic disorders (MDS) with eosinophilia, systemic mastocytosis and acute lymphoblastic leukaemia (Bain 1996).
- HES: After exclusion of the above two categories, cases of persistent, unexplained eosinophilia fall into the category of HES.
References
- ^ Roufosse, F; Weller, PF (Jul 2010). "Practical approach to the patient with hypereosinophilia.". The Journal of allergy and clinical immunology 126 (1): 39–44. doi:10.1016/j.jaci.2010.04.011. PMC 2902584. PMID 20538328.
External links
- Hypereosinophilic Syndrome research in UK
- Hypereosinophilic Syndrome on patient.co.uk
- Hypereosinophilic Syndrome on eMedicine
- Hypereosinophilic Syndrome (HES) on American Academy of Allergy, Asthma & Immunology
- Hypereosinophilic syndrome on Mayo Clinic
UpToDate Contents
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English Journal
- Right ventricular apical obstruction in a patient with hypereosinophilia: Löffler endocarditis.
- Zhuang Q1, Zheng ZY2, Mao W3, Dong BL4, Yang BS1, Ni GB5, Xu QY1, Xu YF1.
- Heart & lung : the journal of critical care.Heart Lung.2015 Mar-Apr;44(2):165-9. doi: 10.1016/j.hrtlng.2014.11.003. Epub 2014 Dec 4.
- Idiopathic hypereosinophilic syndrome (HES) is a rare leukoproliferative systemic disorder characterized by sustained overproduction of eosinophils and poor prognosis. A case that a 67-year-old man with persistent symptoms of heart failure due to cardiac involvement in idiopathic HES is concentrated
- PMID 25481235
- Increasing risks of human dirofilariasis in travelers.
- Diaz JH1.
- Journal of travel medicine.J Travel Med.2015 Mar;22(2):116-23. doi: 10.1111/jtm.12174. Epub 2014 Nov 11.
- BACKGROUND: Dirofilariasis is a zoonotic nematode infection of domestic and wild carnivores that can be transmitted to man by infected mosquitoes.METHODS: Internet search engines were queried with the key words to examine case reports, series, and descriptive analyses of animal and human dirofilaria
- PMID 25384527
- A patient with hemodialysis intolerance and hypereosinophilia.
- Nayak-Rao S1.
- Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.Saudi J Kidney Dis Transpl.2015 Mar-Apr;26(2):366-7.
- PMID 25758892
Japanese Journal
- 左側房室弁置換術後に血栓弁を繰り返し,好酸球増多症候群の関与が疑われた完全房室中隔欠損の1例
- 木戸 高志,西垣 恭一,川平 洋一,前畠 慶人,村上 洋介,江原 英治,川崎 有希,平野 恭悠,鈴木 嗣敏,吉田 葉子,岸本 慎太郎
- Pediatric Cardiology and Cardiac Surgery 30(2), 200-204, 2014
- 好酸球増多症候群(HES)は,原因不明の好酸球増加(>1,500/mm3)が6ヵ月以上持続する状態と定義され,75%以上に弁機能不全等の心合併症を認めると報告されている.HESに関連した弁機能不全は,成人例の報告は散見されるが,小児での報告はない.今回,左側房室弁置換術(lt. AVVR)後に血栓弁を繰り返し,HESとの関連が疑われた小児例を経験したので報告する.症例:4歳女児.Polysp …
- NAID 130003398258
- Corticosteroid Therapy was Effective in Controlling Refractory Coronary Vasospasms Complicated by Hypereosinophilia
- Nomura Tetsuya,Keira Natsuya,Taminishi Shunta,Kubota Hiroshi,Higuchi Yusuke,Ikegame Sho,Terada Kensuke,Kato Taku,Urakabe Yota,Tatsumi Tetsuya
- Internal Medicine 53(7), 735-738, 2014
- … The patient had a history of hypereosinophilia, and as the eosinophilia worsened, more frequent and intense coronary spastic angina (CSA) attacks occurred. …
- NAID 130003392749
- Prominent Hypereosinophilia with Disseminated Intravascular Coagulation as an Unusual Presentation of Advanced Gastric Cancer
- Takeda Haruhiko,Nishikawa Hiroki,Tsumura Takehiko,Sekikawa Akira,Maruo Takanori,Okabe Yoshihiro,Kimura Toru,Wakasa Tomoko,Osaki Yukio
- Internal Medicine 53(6), 563-569, 2014
- A 78-year-old woman was admitted to our hospital complaining of anorexia and purpura of the extremities. She presented with prominent peripheral eosinophilia and disseminated intravascular coagulation …
- NAID 130003392712
Related Links
- Hypereosinophilia Hypereosinophilic syndrome - Categories of HES EPIDEMIOLOGY PATHOPHYSIOLOGY Mechanisms of eosinophil overproduction HES variants - Myeloproliferative HES variants Myeloproliferative neoplasms ...
- Information, Research and Resources ... I have researched Hypereosinophilic Syndrome for the past twenty years. I created this website so patients suffering from this disease, specifically HES, can connect with the leading research ...
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