WordNet

abnormally high acidity (excess hydrogen-ion concentration) of the blood and other body tissues

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酸性症,酸中毒(血液中のアルカリ濃度が異常に低い状態)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/23 07:00:04」(JST)

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Hyperchloremic acidosis is a form of metabolic acidosis associated with a normal anion gap, a decrease in plasma bicarbonate concentration, and in an increase in plasma chloride concentration (see anion gap for a fuller explanation). Although plasma anion gap is normal, this condition is often associated with an increased urine anion gap, due to the kidney's inability to secrete ammonia.

Causes[edit]

Renal tubular acidosis failure of HCO₃^- resorption(i.e., proximal renal tubular acidosis, or overdose of carbonic anhydrase inhibitor) or failure of H⁺ secretion (i.e. in distal renal tubular acidosis)
Renal failure
Gastrointestinal loss of HCO₃^- with diarrhea (vomiting will tend to cause hypochloraemic alkalosis).
Ingestions
- Ammonium chloride, Hydrochloric acid
- Hyperalimentation fluids (i.e., total parenteral nutrition)
Zonisamide ^[1]
Acetazolamide
Alcohol (such as ethanol) can affect anion gap by inducing alcohol dehydrogenase enzyme.
Volume Resuscitation 0.9% Normal Saline provides a chloride load such that infusing more than 3-4L causes acidosis.

References[edit]

^ "Zonegran (Zonisamide) Drug Information: Warnings and Precautions - Prescribing Information at RxList". Rxlist.com. Retrieved 2012-08-21.

External links[edit]

DDB 11673
NIH - Renal Tubular Acidosis
Kellum JA (February 2002). "Fluid resuscitation and hyperchloremic acidosis in experimental sepsis: improved short-term survival and acid-base balance with Hextend compared with saline". Crit. Care Med. 30 (2): 300–5. doi:10.1097/00003246-200202000-00006. PMID 11889298.

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1. 成人における代謝性アシドーシスへのアプローチ approach to the adult with metabolic acidosis
2. 代謝性アシドーシスを有する小児に対するアプローチ approach to the child with metabolic acidosis
3. 下痢または尿路変更に伴う酸塩基および電解質の異常 acid base and electrolyte abnormalities with diarrhea or ureteral diversion
4. 遠位（I型）および近位（II型）尿細管性アシドーシスの病因および診断 etiology and diagnosis of distal type 1 and proximal type 2 renal tubular acidosis
5. 代謝性アシドーシスにおける尿のアニオンギャップおよび浸透圧ギャップ urine anion and osmolal gaps in metabolic acidosis

English Journal

Effects of sodium pyruvate on ameliorating metabolic acidosis.

Yang J1, Zhao JX1, Wang Y1, Chen G1, Cheng WN2, Luo X1, Pei XT1, Zhao L1, Su Q3, Zhou H1.
Artificial cells, nanomedicine, and biotechnology.Artif Cells Nanomed Biotechnol.2016 Feb;44(1):48-55. doi: 10.3109/21691401.2014.901335. Epub 2014 Apr 3.
OBJECTIVE: To examine the effects of sodium pyruvate (SP) on metabolic acidosis.METHODS: For the in vivo experiments, we evaluated effects of SP on an ammonium chloride (NH4Cl)-induced hyperchloremic acidosis rat model. SP was infused at overall doses of 2, 4, and 6 mmol·kg(- 1) for the SP1, SP2, a
PMID 24697727

Stimulating effects of a diet negative in dietary cation-anion difference on calcium absorption from the rumen in sheep.

Wilkens MR1, Praechter C1, Breves G1, Schröder B1.
Journal of animal physiology and animal nutrition.J Anim Physiol Anim Nutr (Berl).2016 Feb;100(1):156-66. doi: 10.1111/jpn.12296. Epub 2015 Feb 2.
The concept of feeding anionic salts in late gestation is widely used to prevent milk fever in dairy cows. While the effects of these diets on renal Ca excretion and tissue responsiveness towards parathyroid hormone have clearly been demonstrated, data on a potential impact on gastrointestinal Ca ab
PMID 25643625

Half-molar sodium-lactate: The osmotic agent we are looking for?

Aramendi I1, Manzanares W2, Biestro A2.
Medicina intensiva / Sociedad Espanola de Medicina Intensiva y Unidades Coronarias.Med Intensiva.2015 Dec 3. pii: S0210-5691(15)00197-7. doi: 10.1016/j.medin.2015.09.002. [Epub ahead of print]
Intracranial hypertension (ICH) is the most important modifiable factor with predictive negative value in brain injury patients. Osmotherapy is the most important first level specific measure in the treatment of ICH. Mannitol 20%, and 3, 7.5, 10, and 23% hypertonic sodium chloride are the most commo
PMID 26655973

Japanese Journal

Clinical Evaluation of Chinese Patients with Primary Distal Renal Tubular Acidosis

Zhang Chunli,Ren Hong,Shen Pingyan,Xu Yaowen,Zhang Wen,Wang Weiming,Li Xiao,Ma Yuhuan,Chen Nan
Internal Medicine 54(7), 725-730, 2015
… Objective Distal renal tubular acidosis (dRTA) is a hyperchloremic metabolic acidosis disorder characterized by a normal anion gap with abnormal urinary hydrogen (H+) excretion. …
NAID 130005063197

回腸導管造設後に高クロール性代謝性アシドーシスを呈した単純性イレウスの1例

山口圭三,辻本広紀,平木修一,高畑りさ,小野聡,山本順司,長谷和生
日本腹部救急医学会雑誌 34(4), 823-826, 2014
症例は69歳，男性。持続する腹痛，嘔気を主訴に近医を受診し，腸閉塞の診断で当院に搬送された。既往歴として15年前に直腸癌に対して骨盤内臓全摘術，回腸導管造設，6年前に食道癌に対して開胸・開腹食道切除術を受けた。入院時，腹部は平坦・軟で腹膜刺激症状を認めず，血液ガス分析ではpH 7.175，Base Excess －17.9mmol/L，Cl 114mEq/Lと高クロール性代謝性アシドーシスを認めた …
NAID 130004890850

遠位尿細管性アシドーシスに糖尿病ケトアシドーシスを合併した1型糖尿病の1例

大濱俊彦,川上恵美子,佐藤愛 [他],齋藤利比古,田中聡,勝盛弘三
糖尿病 57(8), 628-633, 2014
遠位尿細管性アシドーシス（dRTA）に糖尿病ケトアシドーシス（DKA）を合併した1型糖尿病の1例を経験した．症例は50歳，男性．9歳でdRTAと診断，加療され糖尿病の指摘はなかった．2013年9月に口渇，多尿，体重減少を認め，随時血糖値421 mg/dl，尿中ケトン体3＋，HbA1c（NGSP値）11.9 %，IA-2抗体陽性，インスリン自己抗体陽性，動脈血液ガス分析にてpH 7.228，HCO3 …
NAID 130004688055

「高クロル性アシドーシス」

Hyperchloremic acidosis
	Classification and external resources
ICD-10	E87.2
ICD-9	276.2
eMedicine	med/1071

　　[★]

英: hyperchloremic acidosis
同: 高Cl性アシドーシス
関: 尿管S状結腸吻合術

「高塩素血症性アシドーシス」

　　[★]

英: hyperchloremic acidosis
同: 高クロル血症性アシドーシス

「高クロール血性アシドーシス」

　　[★]

英: hyperchloremic acidosis

「hyperchloremic」

　　[★]

adj.

高塩素血症の

関: hyperchloremia

「acidosis」

　　[★] アシドーシス

[1] "Zonegran (Zonisamide) Drug Information: Warnings and Precautions - Prescribing Information at RxList". Rxlist.com. Retrieved 2012-08-21.

リンク元	「高クロル性アシドーシス」「高塩素血症性アシドーシス」「高クロール血性アシドーシス」
関連記事	「hyperchloremic」「acidosis」

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hyperchloremic acidosis