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English Journal

Sakkas LI1, Bogdanos DP2.
Autoimmunity reviews.Autoimmun Rev.2016 Feb;15(2):155-61. doi: 10.1016/j.autrev.2015.10.005. Epub 2015 Oct 21.
Systemic sclerosis (SSc) is characterized by widespread fibrosis, microangiopathy (vasospasms and stenosis), and formation of autoantibodies. T cell activation has been shown to contribute to fibrosis and microvasculopathy in SSc. However, recent evidence suggests that B cells are also likely to con
PMID 26497107

A critical role for alpha-synuclein in development and function of T lymphocytes.

Shameli A1, Xiao W1, Zheng Y1, Shyu S1, Sumodi J1, Meyerson HJ1, Harding CV1, Maitta RW2.
Immunobiology.Immunobiology.2016 Feb;221(2):333-40. doi: 10.1016/j.imbio.2015.10.002. Epub 2015 Oct 20.
Alpha-synuclein is highly expressed in the central nervous system and plays an important role in pathogenesis of neurodegenerative disorders such as Parkinson's disease and Lewy body dementia. Previous studies have demonstrated the expression of α-synuclein in hematopoietic elements and peripheral
PMID 26517968

Auguste D, Maier M, Baldwin C, Aoudjit L, Robins R, Gupta IR, Takano T.
Small GTPases.Small GTPases.2016 Jan 4:0. [Epub ahead of print]
Nephrotic syndrome (NS) describes a group of kidney disorders in which there is injury to podocyte cells, specialized cells within the kidney's glomerular filtration barrier, allowing proteins to leak into the urine. Three mutations in ARHGDIA, which encodes Rho GDP dissociation inhibitor α (GDIα)
PMID 26726844

Suppression of Progesterone-enhanced Hyperactivation in Hamster Spermatozoa by γ-aminobutyric Acid

KON Hiroe,TAKEI Gen L.,FUJINOKI Masakatsu,SHINODA Motoo
Journal of Reproduction and Development 60(3), 202-209, 2014
… It has been recently shown that mammalian spermatozoa were hyperactivated by steroids, amines and amino acids. …
NAID 130003390831

2) mTOR complexesをターゲットとした卵巣癌の分子標的治療 : 浸潤・脈管新生・増殖の抑制を目指して(シンポジウム1:腫瘍「婦人科癌の浸潤・転移機構の解明と臨床応用」,第65回日本産科婦人科学会・学術講演会講演要旨)

馬淵誠士
日本産科婦人科學會雜誌 65(10), 2402-2413, 2013-10-01
… These results suggest that RAD001 could have therapeutic efficacy in human ovarian cancers with hyperactivated AKT/mTORC1 signaling. …
NAID 110009674402

猪又孝元
日本臨床麻酔学会誌 31(5), 846-853, 2011
現在の心不全治療は，目に見えて悪い状態からの脱却を目指す「目に見える治療」と，長期予後改善というエビデンスに基づく「目に見えない治療」とに大別される．前者はその場を乗り切る治療であり，後者は固有の質を改善する治療である．心不全は進行性の病態が特徴的であり，先手先手の介入がより大きな利益を生む．最近では，慢性期予後を意識しての急性期介入，すなわち「目に見える治療」の際に「目に見えない治療」を含有 …
NAID 130004449988