hydroxylases

ヒドロキシラーゼ

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• 1. 小児における原発性副腎不全の原因および臨床症状 causes and clinical manifestations of primary adrenal insufficiency in children

English Journal

• Discovery of novel 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide derivatives as HIF prolyl 4-hydroxylase inhibitors; SAR, synthesis and modeling evaluation.

• Hong YR1, Kim HT2, Ro S3, Cho JM2, Lee SH4, Kim IS4, Jung YH5.
• Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2014 Jul 15;24(14):3142-5. doi: 10.1016/j.bmcl.2014.05.003. Epub 2014 May 15.
• The design, synthesis, and capacity to inhibit HIF prolyl 4-hydroxylases (PHDs) are described for 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide analogs. These analogs revealed two kinds of novel scaffolds as PHD2 inhibitors. Synthetic routes were developed for the preparation of their analog
• PMID 24894560

• Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17β-estradiol biosynthesis in endometrial carcinoma microenvironment.

• Che Q1, Liu BY, Liao Y, Zhang HJ, Yang TT, He YY, Xia YH, Lu W, He XY, Chen Z, Wang FY, Wan XP.
• International journal of cancer. Journal international du cancer.Int J Cancer.2014 Jul 15;135(2):282-94. doi: 10.1002/ijc.28679. Epub 2014 Jan 6.
• Tumor-stroma interactions contribute greatly to intratumoral estrogen biosynthesis in endometrial carcinoma, but the mechanisms involved remain largely unknown. Previous study demonstrated that intratumoral aromatase upregulation in stromal cells participated in this process, but the specific aromat
• PMID 24347287

• Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study.

• Dik VK1, Bueno-de-Mesquita HB, Van Oijen MG, Siersema PD, Uiterwaal CS, Van Gils CH, Van Duijnhoven FJ, Cauchi S, Yengo L, Froguel P, Overvad K, Bech BH, Tjønneland A, Olsen A, Boutron-Ruault MC, Racine A, Fagherazzi G, Kühn T, Campa D, Boeing H, Aleksandrova K, Trichopoulou A, Peppa E, Oikonomou E, Palli D, Grioni S, Vineis P, Tumino R, Panico S, Peeters PH, Weiderpass E, Engeset D, Braaten T, Dorronsoro M, Chirlaque MD, Sánchez MJ, Barricarte A, Zamora-Ros R, Argüelles M, Jirström K, Wallström P, Nilsson LM, Ljuslinder I, Travis RC, Khaw KT, Wareham N, Freisling H, Licaj I, Jenab M, Gunter MJ, Murphy N, Romaguera-Bosch D, Riboli E.
• International journal of cancer. Journal international du cancer.Int J Cancer.2014 Jul 15;135(2):401-12. doi: 10.1002/ijc.28655. Epub 2013 Dec 21.
• Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotype
• PMID 24318358

Japanese Journal

• 胎児の発生や小児の成長,高齢期におけるビタミンCの必要性(<特集>第65回大会シンポジウム「ビタミン研究の新しい息吹」)

• 石神 昭人
• ビタミン 87(12), 665-668, 2013-12-25
• … VC is also a cofactor for numerous biosynthetic enzymes such as prolyl and lysyl hydroxylases for procollagen hydroxylation. …
• NAID 110009686676

• 1P-079 有用ヒドロキシイミノ酸合成を目的とした微生物由来水酸化酵素の特性解析(酵素学,酵素工学,一般講演)

• 原 良太郎,内海 尚子,木野 邦器
• 日本生物工学会大会講演要旨集 65, 37, 2013-08-25
• NAID 110009737459

• Iron facilitator LS081 reduces hypoxia-inducible factor-1α protein and functions as anticancer agent in hepatocellular carcinoma.

• 田中 宏樹,Zhen Li,Katsuya Ikuta,Lynda Addo,Hiroaki Akutsu,Masao Nakamura,Katsunori Sasaki,Takaaki Ohtake,Mikihiro Fujiya,Yoshihiro Torimoto,Jonathan Glass,Yutaka Kohgo
• Cancer Science 103(4), 767-774, 2012-04
• … In normoxic conditions, HIF-1α is hydroxylated by oxygen-dependent prolyl-hydroxylases, which require ferrous iron for its activity. … We focused on the physiological degradation machinery of HIF-1α mediated by prolyl hydroxylases. …
• NAID 120005229773

Related Links

• hydroxylases - definition of hydroxylases by Medical dictionary

hy·drox·y·las·es (hī-drok'si-lās'ez), Enzymes catalyzing formation of hydroxyl groups by addition of an oxygen atom, hence oxidizing the substrate; most ... Both enzymes are pteridin-dependent aromatic amino acid hydroxylases ...

• CiNii 論文 - Effects of Fluorogibberellins on Plant Growth and ...

3β-Fluorogibberellin A_9 (3β-fluoro-GA_9), 3β-fluoro-GA_<20> 3β-fluorodeoxygibberellin C (3β-fluoro-DGC) and 13-fluoro-GA_9 were prepared, and their effects on plant prowth and gibberellin (GA) 3β-hydroxylases were examined. 3β ...

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