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1. 有機酸血症 organic acidemias
2. 避妊のための酢酸メドロキシプロゲステロンデポ剤 depot medroxyprogesterone acetate for contraception
3. 資源の限られた状況における子宮頸癌のスクリーニング screening for cervical cancer in resource limited settings
4. βサラセミアの治療 treatment of beta thalassemia
5. 去勢抵抗性前立腺癌に対する二次内分泌療法 secondary endocrine therapies for castration resistant prostate cancer

Evaluation of oxidized buckypaper as material for the solid phase extraction of cobalamins from milk: Its efficacy as individual and support sorbent of a hydrophilic-lipophilic balance copolymer.

Pérez-Fernández V1, Gentili A2, Martinelli A1, Caretti F1, Curini R1.
Journal of chromatography. A.J Chromatogr A.2016 Jan 8;1428:255-66. doi: 10.1016/j.chroma.2015.07.109. Epub 2015 Aug 1.
This work describes a new analytical method for the determination of four cobalamins (adenosylcobalamin (AdoCbl), methylcobalamin (MeCbl), hydroxocobalamin (OHCbl) and cyanocobalamin (CNCbl)) in cow's milk. The extraction procedure is fast and based on dilution/protein precipitation of a milk sample
PMID 26265001

Chronic administration of the nitroxyl donor 1-nitrosocyclo hexyl acetate limits left ventricular diastolic dysfunction in a mouse model of diabetes mellitus in vivo.

Cao N1, Wong YG1, Rosli S1, Kiriazis H1, Huynh K1, Qin C1, Du XJ1, Kemp-Harper BK1, Ritchie RH2.
Circulation. Heart failure.Circ Heart Fail.2015 May;8(3):572-81. doi: 10.1161/CIRCHEARTFAILURE.114.001699. Epub 2015 Mar 3.
BACKGROUND: Nitroxyl (HNO), a redox congener of nitric oxide (NO·), is a novel regulator of cardiovascular function, combining concomitant positive inotropic, lusitropic, and vasodilator properties. Moreover, HNO exhibits myocardial antihypertrophic and superoxide-suppressing actions. Despite these
PMID 25737497

A Stability-Indicating HPLC Method for the Determination of Nitrosylcobalamin (NO-Cbl), a Novel Vitamin B12 Analog.

Dunphy MJ1, Sysel AM2, Lupica JA1, Griffith K3, Sherrod T3, Bauer JA2.
Chromatographia.Chromatographia.2014 Apr 1;77(7-8):571-589.
Nitrosylcobalamin (NO-Cbl), a novel vitamin B12 analog and anti-tumor agent, functions as a biologic 'Trojan horse', utilizing the vitamin B12 transcobalamin II transport protein and cell surface receptor to specifically target cancer cells. a stability-indicating HPLC method was developed for the d
PMID 24855323

New column packing materials for separation of water-soluble vitamins by high-performance liquid chromatography.

Akiyama Shuzo,Nakashima Kenichiro,Shirakawa Nanako,Yamada Kyoko
Bulletin of the Chemical Society of Japan 63(10), 2809-2813, 1990
… Six vitamins (ascorbic acid, nicotinic acid, thiamine hydrochloride, pyridoxine hydrochloride, hydroxocobalamin acetate, and flavin adenine dinucleotide) in sample solutions could be completely separated within less than 12 min by UV detection on a column packed with morpholinopropylsilyl silica gel by using a phosphate buffer [0.1 M (1 M=1 moldm−3) H3PO4−0.1 M Na2HPO4 …
NAID 130001979962

喜谷喜徳 [他],竹田勝彦,小池久
分析化学 22(6), 719-723, 1973
原子吸光分析法による微量医薬品の迅速定量法の開発を試みた.シアノコバラミン(CyCo)はコバルトを含有する金属キレート化合物である.したがってB12の定量は原子吸光分析法により,コバルト量を測定すると定量できる.本実験には日立207型原子吸光分光光度計を用い,予混合式バーナー,空気-アセチレン燃料,中空陰極ランプを用いて測定を行なった.本報告では測定条 …
NAID 130000943336

CHEMICAL AND BIOCHEMICAL STUDIES ON VITAMIN B12 AND ITS RELATED COMPOUNDS:XIV. PROPERTIES OF A VITAMIN B12-GROUP COMPOUND DERIVED FROM EXOGENOUS COBALAMIN IN THE CELLS OF LACTOBACILLUS LEICHMANNII ACCOMPANYING WITH BIOSYNTHESES OF DEOXYRIBOSYL COMPOUNDS

福井三郎,玉尾嘉邦,加藤忠克,清水祥一
THE JOURNAL OF VITAMINOLOGY 11(2), 81-94, 1965
… Incubation of these cells in a medium containing cyanocobalamin or hydroxocobalamin for 5 hours at 37° brought about a remarkable increase of acid-soluble deoxyribosyl compounds, followed by DNA synthesis without an increase of RNA content as well as the bacterial growth.2. …
NAID 130001750276