hydroflumethiazide

Hydroflumethiazide
Systematic (IUPAC) name
	1,1-Dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	135-09-1
ATC code	C03AA02
PubChem	CID 3647
DrugBank	DB00774
ChemSpider	3521
UNII	501CFL162R
KEGG	D00654
ChEMBL	CHEMBL1763
Chemical data
Formula	C8H8F3N3O4S2
Mol. mass	331.29 g/mol
	SMILES FC(F)(F)c2c(cc1c(NCNS1(=O)=O)c2)S(=O)(=O)N;
	InChI InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16) ; Key:DMDGGSIALPNSEE-UHFFFAOYSA-N ;
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WordNet

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/04 17:22:31」(JST)

Hydroflumethiazide (or Saluron) is a diuretic.

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 - 2013).

Carta F1, Supuran CT.
Expert opinion on therapeutic patents.Expert Opin Ther Pat.2013;23(6):681-91. doi: 10.1517/13543776.2013.780598. Epub 2013 Mar 14.
INTRODUCTION: The benzothiadiazines and high ceiling diuretics (hydrochlorothiazide, hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide and bumetanide) contain primary sulfamoyl moieties acting as zinc-binding groups in the metalloenzyme carbonic anhydrase (CA, EC 4
PMID 23488823

Interfacing on-line solid phase extraction with monolithic column multisyringe chromatography and chemiluminescence detection: An effective tool for fast, sensitive and selective determination of thiazide diuretics.

Maya F1, Estela JM, Cerdà V.
Talanta.Talanta.2010 Jan 15;80(3):1333-40. doi: 10.1016/j.talanta.2009.09.033.
A new, multisyringe flow injection set-up has been developed for the completely automated determination of trace thiazide compounds with diuretic action in different types of samples. The proposed instrumental set-up exploits for the first time, a low pressure on-line solid phase extraction-liquid c
PMID 20006096

Rapid determination of losartan and losartan acid in human plasma by multiplexed LC-MS/MS.

Shah HJ1, Kundlik ML, Patel NK, Subbaiah G, Patel DM, Suhagia BN, Patel CN.
Journal of separation science.J Sep Sci.2009 Oct;32(20):3388-94. doi: 10.1002/jssc.200900287.
A rapid LC-MS/MS method has been developed and validated for the determination of losartan (LOS) and its metabolite losartan acid (LA) (EXP-3174) in human plasma using multiplexing technique (two HPLC units connected to one MS/MS). LOS and LA were extracted from human plasma by SPE technique using O
PMID 19750501

, , ,
Analytical Sciences: X-ray Structure Analysis Online 20, X139-X140, 2004
The title compound, C8H8F3N3O4S2, is a diuretic-antihypertensive agent. The crystal belongs to space group P21 with cell dimensions a = 7.637(1), b = 8.664(1), c = 9.747(1)Å, and β = 110.29(1)°. The f …
NAID 130004442555

伊藤直之,川村清市,樋口誠一
日本獣医師会雑誌 45(3), 174-177, 1992
アセタゾールアミド (5.0mg/kg), フロセミド (0.5mg/kg) およびハイドロフルメサイアザイド (1.0mg/kg) の牛における利尿効果をクリアランス法により検討した.<BR>アセタゾールアミドはナトリウムおよびカリウムクリアランスと尿量の一時的で, 他の薬剤に比較して軽度な増加とクロールクリアランスの持続的な減少を示した. フロセミドは, ナトリウム, カリウム, …
NAID 130003847931

Biopharmaceutical Studies of Thiazide Diuretics. II. High-Performance Liquid Chromatographic Method for Determination of Hydrochlorothiazide in Plasma, Urine, Blood Cells and Bile

山崎勝,伊東容子,鈴鹿卓美,柳沼英哉,伊藤壮一,鎌田皎,折田義正,中浜肇,中西健,安東明夫
Chemical & pharmaceutical bulletin 32(6), 2387-2394, 1984-06-25
… A methanol solution of the drug extract, containing hydroflumethiazide as an internal standard, was chromatographed on a silica gel column with a mobile phase containing n-hexane and ethanol. …
NAID 110003663606