WordNet

resembling glass in transparency or translucency; "the morning is as clear as diamond or as hyaline"-Sacheverell Sitwell (同)hyaloid
a glassy translucent substance that occurs in hyaline cartilage or in certain skin conditions (同)hyalin
sclerosis of the arterioles

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/10/02 13:27:59」(JST)

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Micrograph showing hyaline arteriolosclerosis in the kidney. PAS stain.

Hyaline arteriolosclerosis, also arterial hyalinosis and arteriolar hyalinosis, refers to thickening of the walls of arterioles by the deposition of homogeneous pink hyaline material.^[1] It is a type of arteriolosclerosis, which refers to hardening of the arteriolar wall.

Associations

It is associated with aging, hypertension, diabetes mellitus^[2] and may be seen in response to certain drugs (calcineurin inhibitors).

It is often seen in the context of kidney pathology. In hypertension only the afferent arteriole is affected, while in diabetes mellitus, both the afferent and efferent arteriole are affected.

Etiology

Lesions reflect leakage of plasma components across vascular endothelium and excessive extracellular matrix production by smooth muscle cells, usually secondary to hypertension.

Hyaline arteriolosclerosis is a major morphologic characteristic of benign nephrosclerosis, in which the arteriolar narrowing causes diffuse impairment of renal blood supply, with loss of nephrons.^[2] The narrowing of the lumen can decrease renal blood flow and hence glomerular filtration rate leading to increased renin secretion and a perpetuating cycle with increasing blood pressure and decreasing kidney function.

References

^ Gamble CN (March 1986). "The pathogenesis of hyaline arteriolosclerosis". Am. J. Pathol. 122 (3): 410–20. PMC 1888226. PMID 2420184.
^ ^a ^b Robbins, Stanley L.; Kumar, Vinay (2007). Robbins basic pathology. Saunders/Elsevier. p. 356. ISBN 0-8089-2366-8.

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English Journal

Serum Complement C3 Predicts Renal Arteriolosclerosis in Non-Diabetic Chronic Kidney Disease.

Kojima C, Takei T, Ogawa T, Nitta K.SourceDepartment of Internal Medicine IV, Tokyo Women's Medical University.
Journal of atherosclerosis and thrombosis.J Atheroscler Thromb.2012 Aug 1. [Epub ahead of print]
Aim: Complement C3 (C3) is one of the major mediators of inflammation. Serum C3 has been shown to be correlated with the presence of atherosclerosis. We examined whether the serum C3 level might be correlated with the severity of renal arteriolosclerosis in patients with chronic kidney disease (CKD)
PMID 22863782

Chronic kidney disease, severe arterial and arteriolar sclerosis and kidney neoplasia: on the spectrum of kidney involvement in MELAS syndrome.

Piccoli GB, Bonino LD, Campisi P, Vigotti FN, Ferraresi M, Fassio F, Brocheriou I, Porpiglia F, Restagno G.SourceSS Nephrology ASOU san Luigi, Orbassano, Torino, Italy. gbpiccoli@yahoo.it
BMC nephrology.BMC Nephrol.2012 Feb 21;13:9.
BACKGROUND: MELAS syndrome (MIM ID#540000), an acronym for Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-like episodes, is a genetically heterogeneous mitochondrial disorder with protean manifestations and occasional kidney involvement. Interest in the latter is rising due to the identifi
PMID 22353239

Japanese Journal

病理診断アトラス(6) : 循環器系2:血管-動脈硬化,動脈瘤,マルファン症候群

澤田達男,遠井素乃,小林槇雄
東京女子医科大学雑誌 77(9/10), 480-486, 2007-10
… Arteriosclerosis is a general term for atherosclerosis, Monckeberg arteriosclerosis and arteriolosclerosis, all of which involve sclerosis of blood vessels. … Arteriolosclerosis is characterized by hyaline thickening or proliferative change in small arteries, which are usually associated with hypertension and diabetes mellitus. …
NAID 110007525310